DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and MPDZ

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	1147	Identity:	231/1147 - (20%)
Similarity:	375/1147 - (32%)	Gaps:	378/1147 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 SAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLS 200
            |.|..:||   |.|.|:...|||...|:...  |.|...|   ..|:.:...|:.....|...|.
Human  1161 SLGISIVG---GRGMGSRLSNGEVMRGIFIK--HVLEDSP---AGKNGTLKPGDRIVEVDGMDLR 1217

  Fly   201 GTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPP-----NSIL----KGSKENLLQNT 256
            ..|        |.|.:.                |..:.|.|     .||:    |....:||.|.
Human  1218 DAS--------HEQAVE----------------AIRKAGNPVVFMVQSIINRPRKSPLPSLLHNL 1258

  Fly   257 Y--YNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSH 319
            |  ||..:.:....|.....|......||..:... |..:||...:|:.|.|.    ||...::.
Human  1259 YPKYNFSSTNPFADSLQINADKAPSQSESEPEKAP-LCSVPPPPPSAFAEMGS----DHTQSSAS 1318

  Fly   320 WLDPRLSKYQKKSLEDCCEDELPYGWEKIED------------------SMYGMYFIDHVNR--- 363
            .:...:.|          |||..|.|:.|.:                  |..|:....:.:|
Human  1319 KISQDVDK----------EDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373

  Fly   364 -----------------RTQYENPVLEAKRRAAEQSQQQQQMQ-------------QQQQQMQEQ 398
                             |.|..:.:||...:.......|....             .:.:....|
Human  1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQ 1438

  Fly   399 RSKTPTALSETMPTEAAEAHEQE-----------EDESPMKLPYKFTRNPA---ELQGQRINTT- 448
            .:..|....|.:|:.:.....:|           ..:|...|.|..::..|   .|....:.|:
Human  1439 MAVCPGNAVEPLPSNSENLQNKELGYHRFSLYSKPRQSSSHLVYLCSQLIAVQLHLTEPTVTTSD 1503

  Fly   449 ---------------LLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVL 498
                           |.|...|||..|...|..:|      :.||::..:|.|..||:|:.||.:
Human  1504 AAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSG------VIIKSLTEHGVAATDGRLKVGDQI 1562

  Fly   499 VYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTM--AVDGRESDK 561
            :.|:|..|:||.    :..|.|:|...:..::      |.....:|:::.|.:.  |..|.:.:.
Human  1563 LAVDDEIVVGYP----IEKFISLLKTAKMTVK------LTIHAENPDSQAVPSAAGAASGEKKNS 1617

  Fly   562 QRRLNMDGNYNFLDLSG----EGAKKTSGSGSGFILMKKPEI--------YTFSIMKGSMGFGFT 614
            .:.|       .:..||    |..:.||.|.:..|....|..        .|..|.||..|.|.:
Human  1618 SQSL-------MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1675

  Fly   615 I---ADSACGQ-IVKKILDRNCCT---QLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTA 672
            |   :|:..|. |:.::.:.....   :|..||.:||:||:::|...|...:.:|::    ||..
Human  1676 IVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ----TPQR 1736

  Fly   673 VKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLV 737
            |::.                                |:|.:.|..:      :||         .
Human  1737 VRLT--------------------------------LYRDEAPYKE------EEV---------C 1754

  Fly   738 DTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERL 802
            ||....:| :.|.               |.|.|...||.|.:...:.||
Human  1755 DTLTIELQ-KKPG---------------KGLGLSIVGKRNDTGVFVSDI---------------- 1787

  Fly   803 AEVTLQG---DANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQ 864
                ::|   ||:|.:      ||...:.:.:.|...               .|.|.|::...
Human  1788 ----VKGGIADADGRL------MQGDQILMVNGEDVR---------------NATQEAVAALL-- 1825

  Fly   865 YSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVS---EDADQCEL 926
            ...|.|..|:..||  :.....|:||        |.|..|.|    .|:|...:   ..:...|.
Human  1826 KCSLGTVTLEVGRI--KAGPFHSERR--------PSQSSQVS----EGSLSSFTFPLSGSSTSES 1876

  Fly   927 TEVTLERQAL------------------GFGFRIVGGTEEGS-----QVTVGHIVPGGAADQDQR 968
            .|.:.::.||                  ..|..|.||.  ||     .:.:..:.|.|.|.|.|:
Human  1877 LESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGV--GSPLGDVPIFIAMMHPTGVAAQTQK 1939

  Fly   969 INTGDEILSIDGINVLNSSHHKVVSLVGESA--------LRGQVTMILRRRRTPLLQQAPVSTQL 1025
            :..||.|::|.|.:....:|.:.|:|:..::        ..|.|:::...      ||.|.|:.|
Human  1940 LRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGH------QQEPASSSL 1998

  Fly  1026 --------RRYPYDV-------IVSRHENEGFGFVIISSSNHYYGSTIGKL-------IPGSPAD 1068
                    ..:..|:       |......:|.||.|:..    |||..|.|       .....|.
Human  1999 SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGG----YGSPHGDLPIYVKTVFAKGAAS 2059

  Fly  1069 RCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTI 1110
            ..|.||.||:|:|||...:.|::|.:.|.::|.:...|.|.:
Human  2060 EDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	7/28 (25%)
		WW	342..372	CDD:238122	8/67 (12%)
		PDZ	443..534	CDD:214570	26/106 (25%)
		DegQ	<455..534	CDD:223343	23/78 (29%)
		PDZ_signaling	606..668	CDD:238492	18/68 (26%)
		PDZ	925..1011	CDD:214570	25/116 (22%)
		PDZ_signaling	1029..1110	CDD:238492	27/94 (29%)
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492	26/87 (30%)
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	560..629	CDD:238492
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492	24/110 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		11/50 (22%)
		PDZ	1347..1433	CDD:214570	8/85 (9%)
		PDZ_signaling	1514..1593	CDD:238492	26/94 (28%)
		MPDZ_u10	1595..1659	CDD:374710	13/70 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		10/51 (20%)
		PDZ	1660..1744	CDD:214570	24/119 (20%)
		PDZ_signaling	1758..1836	CDD:238492	23/136 (17%)
		PDZ_signaling	1893..1978	CDD:238492	19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910