DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and UFD4

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	97/533 - (18%)
Similarity:	185/533 - (34%)	Gaps:	157/533 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 HESHDDPGDGLGPLPPKWETAYTERGEL-----YFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDE 340
            ||||.:..|.:  :..:.|..|.|.|.:     |:.|.:..     :..||.......:|..:|:
Yeast    12 HESHSENSDYM--MDTQVEDDYDEDGHVQGEYSYYPDEDED-----EHMLSSVGSFEADDGEDDD 69

  Fly   341 LPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTA 405
            ..|..|.....:||.:       |||          ..:::.:.:::...::.....:....|..
Yeast    70 NDYHHEDDSGLLYGYH-------RTQ----------NGSDEDRNEEEDGLERSHDNNEFGSNPLH 117

  Fly   406 LSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQ---GQRINTTLLKSSRGLGFT-IVGSDGS 466
            |.:.:.| .|:..||....|.....:...|...|:.   |.|:..:...|:|....: ::.:.|:
Yeast   118 LPDILET-FAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGN 181

  Fly   467 AGGD----------------------VEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGY 509
            |..|                      |:..:.::|::.|..|.|..::...::.:.: ..|
Yeast   182 ASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQM-QAC---- 241

  Fly   510 THHDMVNIFQ------SILPGERAALEVCRGYPLPFDPNDPNTEVVTTM----AVDGRESDKQRR 564
              ..|.|:|:      ||...|. .:.:.:|..:.....|...:|:.|:    .|.||:..|..:
Yeast   242 --RCMYNLFEVCPESISIAVDEH-VIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQ 303

  Fly   565 LNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQI------ 623
            |::  ...|.|.....|::.:                           ..|..:||..|
Yeast   304 LSI--YVQFFDFLTIHAQRKA---------------------------IAIVSNACSSIRTDDFK 339

  Fly   624 --------VKKIL----DRNCCTQLMEGDVLLEINGL--NVRNKPHFYVVELLKECSQTTPTAVK 674
                    :|.|.    |:...|:|:  :.:..|.|.  .|......:.::|::...|    .|.
Yeast   340 TIVEVLPTLKPIFSNATDQPILTRLV--NAMYGICGALHGVDKFETLFSLDLIERIVQ----LVS 398

  Fly   675 IQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVD- 738
            ||    |.|..|.|..|:.:..:|.                ::|:.|.:::|      ||.:||
Yeast   399 IQ----DTPLENKLKCLDILTVLAM----------------SSDVLSRELRE------KTDIVDM 437

  Fly   739 -TRRSRVQIQSPN 750
             ||..:...:|||
Yeast   438 ATRSFQHYSKSPN 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	6/33 (18%)
		WW	342..372	CDD:238122	7/29 (24%)
		PDZ	443..534	CDD:214570	18/119 (15%)
		DegQ	<455..534	CDD:223343	15/107 (14%)
		PDZ_signaling	606..668	CDD:238492	13/81 (16%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900