Protein Alignment Magi and Grip1

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: XP_038935886.1
• Gene: Grip1 / 84016
• RGDID: 621667
• Length: 1171
• Species: Rattus norvegicus
• Alignment Length: 947
• Identity: 188/947 - (19%)
• Similarity: 317/947 - (33%)
• Gaps: 315/947 - (33%)

  Fly   400 SKTPTALSETMPTEAAEAHE----QEEDESPMKLPYKFTRN------------------PAELQG 442
            |:.|..|::|........||    ...||||      :|::                  |.|.:|
  Rat    36 SREPPDLNDTKGNVDQSPHELLAKPNSDESP------YTKSASQTKPPDGALAVRRQSIPEEFKG 94

  Fly   443 QRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVL 507
            ..:...:.|....||.|:     |.|.|.:...::..:...|.|....||..||.:..||...:.
  Rat    95 STVVELMKKEGTTLGLTV-----SGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLA 154

  Fly   508 GYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYN 572
            .:.|.:::::.:::  |||..|||  .|.||
  Rat   155 KFRHDEIISLLKNV--GERVVLEV--EYELP---------------------------------- 181

  Fly   573 FLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRN------ 631
                      ..|..||. ::.:..|:   ::.|....|||.|...|..       |||
  Rat   182 ----------PVSIQGSS-VMFRTVEV---TLHKEGNTFGFVIRGGAHD-------DRNKSRPVV 225

  Fly   632 -CCTQ----------LMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPAN 685
             .|.:          :..||.||.::|:.:....|...:.:||:|.|.....::...:..|..|.
  Rat   226 ITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVAT 290

  Fly   686 NTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADL---YSTQV---KEVLPM-RPKTPLVDTRRSR 743
            .:...|.:|                 :|||.|.|   .:|.|   |:|:.: :.|:..:..|...
  Rat   291 ASGPLLVEV-----------------AKTPGASLGVALTTSVCCNKQVIVIDKIKSASIADRCGA 338

  Fly   744 VQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQ 808
            :.:          ||...:.:...::..|..::...|....|      ..|:..|......:.|:
  Rat   339 LHV----------GDHILSIDGTSMEYCTLAEATQFLANTTD------QVKLEILPHHQTRLALK 387

  Fly   809 GDANGGIYGMPPSMQPLPL-PLA----------HHESCYCYDCQAQRYR----------PGYFVQ 852
            |..:..|   ..|.:.||. |.|          ||...:...|:.....          |.....
  Rat   388 GPDHVKI---QRSDRQLPWDPWASSQCSVHTNHHHNPHHPDHCRVPALAFPKALTPNSPPAMVSS 449

  Fly   853 AQQAAMS---------GTTGQ--YSPLQTAHLQNERIQRR--VNELLSDRRRVGFANLDPPQQMQ 904
            :...:||         ||..:  ||......:...|::::  .:.|......||.|.     |:.
  Rat   450 SSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG-----QVV 509

  Fly   905 HSPSWRNGALLDVSEDADQCELTEVTLERQAL-GFGFRIVG---GTEE-GSQVTVGHIVPGGAAD 964
            |:                  |.|||.|....: |||.::.|   .||. .|...:.:|.....|:
  Rat   510 HT------------------ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAE 556

  Fly   965 QDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQAPVSTQLRRYP 1029
            :...:..||.:::|:||...:|:..:...|:.:|::..:||:.:.
  Rat   557 RCGVLQIGDRVMAINGIPTEDSTFEEANQLLRDSSITSKVTLEIE-------------------- 601

  Fly  1030 YDVIVS--------------RHENEGFGFVIISSSNHYYGS--TIGKLIPGSPADRCGELKVGDR 1078
            :||..|              :|..| .|..|.|.|:...|.  .|..:..||.|.|.|.|::||:
  Rat   602 FDVAESVIPSSGTFHVKLPKKHSVE-LGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDK 665

  Fly  1079 IVAVNRIEIAGMSHGDVVNLIKESGLHVRLTI------------------GVPLKE-GGPSPGGS 1124
            ::|::.|.:...|..|.|.::::....|:|.|                  .|.||. |||
  Rat   666 LLAIDNIRLDSCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP----- 725

  Fly  1125 SVGVS-SNTPLQASP----SLLKAQLSHQQ----------QLPQQHLQQAQLNHHHQHLEM---- 1170
             :|:: |.|.....|    ||.|..|:.:.          .:....|:...|:.....|:|
  Rat   726 -LGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 789

  Fly  1171 ----------------PMSMPVPGHGSYL----ERPS 1187
                            |..:|:|.|.|.|    |.||
  Rat   790 VTLKIKKQTDAQPASSPKKLPIPSHSSDLGDGEEDPS 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800
		WW	342..372	CDD:238122
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	22/88 (25%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	21/96 (22%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	23/88 (26%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	27/115 (23%)
Grip1	XP_038935886.1	PDZ1_GRIP1-2-like	96..178	CDD:467175	22/90 (24%)
		PDZ2_GRIP1-2-like	193..281	CDD:467169	21/97 (22%)
		PDZ3_GRIP1-2-like	293..378	CDD:467172	19/117 (16%)
		PDZ4_GRIP1-2-like	507..607	CDD:467174	28/137 (20%)
		PDZ5_GRIP1-2-like	615..699	CDD:467170	24/84 (29%)
		PDZ6_GRIP1-2-like	712..796	CDD:467171	18/89 (20%)
		PDZ7_GRIP1-2-like	1043..1127	CDD:467173