DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and ITCH

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_001244066.1 Gene:ITCH / 83737 HGNCID:13890 Length:903 Species:Homo sapiens


Alignment Length:320 Identity:74/320 - (23%)
Similarity:114/320 - (35%) Gaps:100/320 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 AATSFATFNGNS-NLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTLSSAGTDVVGNGSGHG 149
            :|:..|.|.|.| |.:.|.:...:|......|:.:|.| |||                       
Human   191 SASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAG-AGE----------------------- 231

  Fly   150 NGTVTGNGEKS---GGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSV 211
            |..|:||...|   ||..|........||||..::.||                           
Human   232 NRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPAS--------------------------- 269

  Fly   212 HNQFISGLPSNGIGSNGVHGGAATGRGGPPN---SILKGSKENLLQNTYYNGETGDSSLGSECGV 273
                ::|.||    :.....|::||...|.|   :..:|:...|:.....:|.:|...|....  
Human   270 ----VNGSPS----ATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVT-- 324

  Fly   274 GDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCE 338
                             ..||||.||....:.|.:|::||....:.|..|               
Human   325 -----------------QAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--------------- 357

  Fly   339 DELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQ 398
            :.||.|||:..|:|..:|::||..|.|.::.|.||:.|...:...|:.|:|...||..::
Human   358 EPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQR 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 10/28 (36%)
WW 342..372 CDD:238122 12/29 (41%)
PDZ 443..534 CDD:214570
DegQ <455..534 CDD:223343
PDZ_signaling 606..668 CDD:238492
PDZ 925..1011 CDD:214570
PDZ_signaling 1029..1110 CDD:238492
ITCHNP_001244066.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..301 34/162 (21%)
WW 328..357 CDD:306827 10/28 (36%)
HUL4 <359..903 CDD:227354 21/59 (36%)
Required for interaction with FYN. /evidence=ECO:0000269|PubMed:16387660 395..471 6/23 (26%)
MAP kinase docking site. /evidence=ECO:0000250 574..583
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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