DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and Hectd3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_780453.1	Gene:	Hectd3 / 76608	MGIID:	1923858	Length:	861	Species:	Mus musculus

Alignment Length:	348	Identity:	74/348 - (21%)
Similarity:	110/348 - (31%)	Gaps:	110/348 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 PGDGLGPLPPKWETAYTERGELYFIDHNTG----TSHWLDPRLSKYQ-KKSLEDCCEDELPYGWE 346
            ||.|.|||....::....||...   ..||    ..|.|..:|:|.| .:.|.||..||   ||.
Mouse    82 PGTGSGPLRAARDSIELRRGACV---RTTGEELCNGHGLWVKLTKEQLAEHLSDCSLDE---GWL 140

  Fly   347 KI-EDSMYGMYFI-----DHVNRRTQY----ENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSK 401
            .: ..:..|...:     ||:.|:.|.    ..|||          :.:|.:..........|.:
Mouse   141 LVCRPAEGGARLVPIDTPDHLQRQQQLFGVDYRPVL----------RWEQVVDLTYSHRLGSRPQ 195

  Fly   402 TPTALSETM-------PTEAAEAHEQ----------EEDESPMKLPYKFTRNPAELQGQRINTTL 449
            ...|.:|.:       ||...|..|.          :|||:...:.............:..|.:.
Mouse   196 PAEAYTEAIQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSVKQYVESIDVSSYTEEFNVSC 260

  Fly   450 LKSSRGLGFTIVGSDGS----------AGGDV------------EEFLQIKTVVPNGPAWLDGQL 492
            |..|.  ..|...||||          ..|.:            :.|:..:.||..|..  |...
Mouse   261 LTDSN--ADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEG--DNLK 321

  Fly   493 QTGDVLV---YVNDTCVL-GYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMA 553
            :..||.:   .:.|.||| ..|.|         ||.....:..||        :|         .
Mouse   322 KLSDVNIDETLIGDVCVLEDMTVH---------LPIIEIRIVECR--------DD---------G 360

  Fly   554 VDGR------ESDKQRRLNMDGN 570
            :|.|      :|.:||.|.::.:
Mouse   361 IDVRLRGVKIKSSRQRELGLNAD 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	7/32 (22%)
		WW	342..372	CDD:238122	8/39 (21%)
		PDZ	443..534	CDD:214570	25/116 (22%)
		DegQ	<455..534	CDD:223343	22/104 (21%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Hectd3	NP_780453.1	APC10-HECTD3	238..371	CDD:176487	29/162 (18%)
		HECTc	528..849	CDD:214523
		HECT	586..845	CDD:279026
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900