DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Smurf1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	335	Identity:	72/335 - (21%)
Similarity:	121/335 - (36%)	Gaps:	89/335 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LKKSASAVIGNSASREDVASL--SGTSSLNSQMSVHNQFISGLPSNG--IGSNGVHGGAAT---- 235
            |..:.|.:......|.|:..|  |.|.::..|:.|..|....:...|  :...|:.....|
Mouse   101 LSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYED 165

  Fly   236 -GRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGV---------------------GDVQH 278
             |.|.|.:.:::       :...|...||.::.|..|..                     |.:|.
Mouse   166 SGPGRPLSCLME-------EPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQT 223

  Fly   279 QNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRL------------------ 325
            ..:..|   |.....||..:|...|.:|::||:...||.|.|.|||:
Mouse   224 PQNRPH---GHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEF 285

  Fly   326 ------SKYQKKSLEDCCE-DELPYGWEKIEDSMYG-MYFIDHVNRRTQYENPVLEAKRRAAEQS 382
                  |:.:..:..:|.| ..||.||| :..::.| :||:||.||.||:.:|      |.....
Mouse   286 LLQGHTSEPRDLNSVNCDELGPLPPGWE-VRSTVSGRIYFVDHNNRTTQFTDP------RLHHIM 343

  Fly   383 QQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQ---EEDESPMKLPYKFTRNPAELQGQR 444
            ..|.|:::..|.:|             :|:|.:...|:   :..|..:....|..|:...||..:
Mouse   344 NHQCQLKEPSQPLQ-------------LPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQ 395

  Fly   445 INTTLLKSSR 454
            .....::.||
Mouse   396 AGHCRIEVSR 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	11/28 (39%)
		WW	342..372	CDD:238122	14/30 (47%)
		PDZ	443..534	CDD:214570	2/12 (17%)
		DegQ	<455..534	CDD:223343	72/335 (21%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	9/36 (25%)
		WW	236..267	CDD:197736	13/30 (43%)
		WW	307..339	CDD:197736	15/38 (39%)
		HECTc	399..754	CDD:238033	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900