DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Grip1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	996	Identity:	191/996 - (19%)
Similarity:	335/996 - (33%)	Gaps:	327/996 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 LPYGWEKIEDSMYGMYFIDHVNRR-TQYENPVLEAKRRAAEQSQQQQQMQ----------QQQQQ 394
            ||:.|              :|.:. |...:|:...::.......::|:.:          |..::
Mouse    22 LPFSW--------------YVRKEFTCCRSPLQPPEQSPCVHFAREQRARMIAVSFKCRCQILRR 72

  Fly   395 MQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFT 459
            :.:..|....:.|:|.|.:.|.|..::.             .|.|.:|..:...:.|....||.|
Mouse    73 LTKDESPYTKSASQTKPPDGALAVRRQS-------------IPEEFKGSTVVELMKKEGTTLGLT 124

  Fly   460 IVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPG 524
            :     |.|.|.:...::..:...|.|....||..||.:..||...:..:.|.:::::.:::  |
Mouse   125 V-----SGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 182

  Fly   525 ERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGS 589
            ||..|||  .|.||                                            ..|..||
Mouse   183 ERVVLEV--EYELP--------------------------------------------PVSVQGS 201

  Fly   590 GFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRN-------CCTQ----------LM 637
            . ::.:..|:   ::.|....|||.|...|..       |||       .|.:          :.
Mouse   202 S-VMFRTVEV---TLHKEGNTFGFVIRGGAHD-------DRNKSRPVVITCVRPGGPADREGTIK 255

  Fly   638 EGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRK 702
            .||.||.::|:.:....|...:.:||:|.|.....::...:..|..|..:...|.:|
Mouse   256 PGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEV-------- 312

  Fly   703 NFVGSGLFRSKTPTADL---YSTQV---KEVLPM-RPKTPLVDTRRSRVQIQSPNNEVDDEGDGA 760
                     :|||.|.|   .:|.|   |:|:.: :.|:..:..|...:.:......:|     .
Mouse   313 ---------AKTPGASLGVALTTSVCCNKQVIVIDKIKSASIADRCGALHVGDHILSID-----G 363

  Fly   761 AAAERKPLQLQTQGKSNSSLQ-ELDDIPYMD--------PYPKISRLSERLAEVTLQGDANGGIY 816
            .:.|...|...||..:|::.| :|:.:|:..        .:.||.| |:|............|::
Mouse   364 TSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQR-SDRQHPWDAWASNQCGVH 427

  Fly   817 ----------------------GMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMS 859
                                  .:||:..|..:|.:...|...|...:..              .
Mouse   428 TNHHHNTYHPDHCRVPALTFPKALPPNSPPAMVPSSSPTSMSAYSLSSLN--------------M 478

  Fly   860 GTTGQ--YSPLQTAHLQNERIQRR--VNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSED 920
            ||..:  ||......:...|::::  .:.|......||.|.     |:.|:
Mouse   479 GTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG-----QVVHT-------------- 524

  Fly   921 ADQCELTEVTLERQAL-GFGFRIVG---GTEE-GSQVTVGHIVPGGAADQDQRINTGDEILSIDG 980
                |.|||.|....: |||.::.|   .||. .|...:.:|.....|::...:..||.:::|:|
Mouse   525 ----ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAING 585

  Fly   981 INVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQAPVSTQLRRYPYDVIVS---------- 1035
            |...:|:..:...|:.:|::..:||:.:.                    :||..|
Mouse   586 IPTEDSTFEEANQLLRDSSITSKVTLEIE--------------------FDVAESVIPSSGTFHV 630

  Fly  1036 ----RHENEGFGFVIISSSNHYYGS--TIGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGD 1094
                :|..| .|..|.|.|:...|.  .|..:..||.|.|.|.|::||:::|::.|.:...|..|
Mouse   631 KLPKKHSVE-LGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMED 694

  Fly  1095 VVNLIKESGLHVRLTI------------------GVPLKE-GGPSPGGSSVGVS-SNTPLQASP- 1138
            .|.::::....|:|.|                  .|.||. |||      :|:: |.|.....|
Mouse   695 AVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP------LGITISGTEEPFDPI 753

  Fly  1139 ---SLLKAQLS---------------HQQQLPQQHLQQA---------------QLNHHHQHLEM 1170
               ||.|..|:               :...|..:.|.:|               :.....|....
Mouse   754 IISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASS 818

  Fly  1171 PMSMPVPGHGSYL----ERPS 1187
            |...|:|||...|    |.||
Mouse   819 PKKFPIPGHSGDLGDGEEDPS 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122	5/30 (17%)
		PDZ	443..534	CDD:214570	22/90 (24%)
		DegQ	<455..534	CDD:223343	21/78 (27%)
		PDZ_signaling	606..668	CDD:238492	19/78 (24%)
		PDZ	925..1011	CDD:214570	24/90 (27%)
		PDZ_signaling	1029..1110	CDD:238492	26/96 (27%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492	22/88 (25%)
		PDZ_signaling	209..292	CDD:238492	21/92 (23%)
		PDZ_signaling	307..390	CDD:238492	21/104 (20%)
		PDZ_signaling	526..614	CDD:238492	23/87 (26%)
		PDZ_signaling	627..711	CDD:238492	23/84 (27%)
		PDZ_signaling	727..808	CDD:238492	17/86 (20%)
		PDZ_signaling	1058..1138	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840