DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Ube3b

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001137366.1	Gene:	Ube3b / 687633	RGDID:	1583074	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	171/952 - (17%)
Similarity:	271/952 - (28%)	Gaps:	403/952 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LAPPGGHHLRPPPPP-------------ALKKSASA------VIGNSASREDVASLSG-----TS 203
            |.||.....:|.|..             |.:||||.      |.|......:|..:..     .:
  Rat   407 LEPPEPVPAQPQPSSPQTVLPVKSLLKRAFQKSASVRNILKPVGGRRVDSTEVRKVCSICVLYQT 471

  Fly   204 SLNSQMSVHNQFISGLPSNG---------IGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYN 259
            ||.:...:..|.::||....         |...|.|||            ||...|.|      |
  Rat   472 SLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGG------------LKLFLECL------N 518

  Fly   260 GETGDSS-------LGSECG------VGDVQHQNHESHDDP-----------------------G 288
            .:||:|.       |..:|.      :.|:     |.:::.                       .
  Rat   519 NDTGESKQLLAMLMLFCDCSRHLITILDDI-----EVYEEQISFKLEELVTISSFLNSFVFKMIW 578

  Fly   289 DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMY 353
            ||:      .|.|..|..||:...|.     ||   :..|::    ||.....|......:|...
  Rat   579 DGI------VENAKGETLELFQSVHG-----WL---MVLYER----DCRRRFAPEDHWLRKDLKP 625

  Fly   354 GMYF--------------------IDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQ 398
            |:.|                    :.|.||...:.|.|::.|.:..               :.|.
  Rat   626 GVLFQELDKDRKRAQLILLHIPHVVPHKNRVLLFRNMVIKEKEKLG---------------LVET 675

  Fly   399 RSKTP--TALSETMPTEAAEAHEQ--EEDESPMK--LPYKFTRNPAELQGQRINTTLLKSSRGLG 457
            .|.:|  |.::........:.:||  :..:..||  :..||..:                   ||
  Rat   676 SSASPHVTHITIRRSRMLEDGYEQLRQLPQHAMKGAIRVKFVSD-------------------LG 721

  Fly   458 FTIVGSDGSAGGDVEEFLQ--IKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQS 520
            ....|.|  ..|..:|||:  ||.|.  .||....:..:||..:|.:.|   .|.|.:.:.:|:.
  Rat   722 VDEAGID--QDGVFKEFLEEIIKRVF--DPALNLFKTTSGDERLYPSPT---SYIHENYLQLFEF 779

  Fly   521 ILPGERAALEVCRG--YPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKK 583
            :  |:.....|..|  ..:||.....:..:....:|.....|:...|:.:...|...:     |:
  Rat   780 V--GKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSI-----KR 837

  Fly   584 TSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGL 648
            ..|.                  ...:|...:..:...||:|        |.:|:.|...:.:...
  Rat   838 YDGD------------------VADLGLTLSYDEDVMGQLV--------CHELVPGGKTIPVTDE 876

  Fly   649 N----VRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGL 709
            |    :....||.:...:|                     |.|.|.:               ||
  Rat   877 NKISYIHLMAHFRMHTQIK---------------------NQTAALI---------------SG- 904

  Fly   710 FRS--KTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQT 772
            |||  |.....::||...:.|                 |...|.|:|
  Rat   905 FRSIIKPEWIRMFSTPELQRL-----------------ISGDNAEID------------------ 934

  Fly   773 QGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYC 837
                      |:|:.....|                   .||.:|            :|....:.
  Rat   935 ----------LEDLKKHTVY-------------------YGGFHG------------SHRVIVWL 958

  Fly   838 YDCQAQRYRPGYFVQAQQAAM---SGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDP 899
            :|..|..:.||      :.||   ..|:....||                       :|||.|.|
  Rat   959 WDILASDFTPG------ERAMFLKFVTSCSRPPL-----------------------LGFAYLKP 994

  Fly   900 PQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAAD 964
            |..::         .::||:|.|    |..||.....||             .|:....|||
  Rat   995 PFSIR---------CVEVSDDQD----TGDTLGSVLRGF-------------FTIRKREPGG--- 1030

  Fly   965 QDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTM 1006
               |:.|     |....|:|...::...|::.|. ||..::|
  Rat  1031 ---RLPT-----SSTCFNLLKLPNYSKKSVLREK-LRYAISM 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	8/28 (29%)
		WW	342..372	CDD:238122	8/49 (16%)
		PDZ	443..534	CDD:214570	22/92 (24%)
		DegQ	<455..534	CDD:223343	22/80 (28%)
		PDZ_signaling	606..668	CDD:238492	11/65 (17%)
		PDZ	925..1011	CDD:214570	19/82 (23%)
		PDZ_signaling	1029..1110	CDD:238492
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	109/619 (18%)
Ube3b	NP_001137366.1	HECTc	709..1067	CDD:214523	106/594 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900