DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and Wwp2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	334	Identity:	81/334 - (24%)
Similarity:	119/334 - (35%)	Gaps:	79/334 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NLNSSLANGSSR------KFNCSRDNVDDGGDAGEMAAASQTLSSAGTDV----VGNGSGHGNGT 152
            ||::.|.|...:      ..|...:|.......||:     |:...|..|    |.|||...:|:
Mouse   102 NLSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGEL-----TIFLDGPTVDLGSVPNGSAVTDGS 161

  Fly   153 VTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSV-----H 212
            ...:.|.||....|...| :||       |.:...|.|.:.......:.|::..|:.|.     |
Mouse   162 QPPSRESSGTAIAPETRH-QPP-------STNCFGGRSRTHRHSGGSARTATAASEQSPGARNRH 218

  Fly   213 NQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKG------------SKENL----LQNTYYNGE 261
            .|.:....|:|: :||......|....|..|.:.|            |..|.    .|:|...||
Mouse   219 RQPVKNSSSSGL-ANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGE 282

  Fly   262 TGDSSLGSECGVGDVQHQNHESHDDPGDGLGP--LPPKWETAYTERGELYFIDHNTGTSHWLDPR 324
            ...:| |::              ..|.....|  ||..||......|.:|::||||.|:.|
Mouse   283 EASTS-GTQ--------------QLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTW---- 328

  Fly   325 LSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQ 389
                         |..||.||||..|.....|::||..|.|.::.|..|..|...:...|:.|:|
Mouse   329 -------------ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQ 380

  Fly   390 QQQQQMQEQ 398
            ...|...::
Mouse   381 GAMQHFSQR 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	12/29 (41%)
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	9/44 (20%)
		PRK07003	<149..>299	CDD:235906	37/173 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		37/173 (21%)
		WW	302..331	CDD:366073	13/45 (29%)
		WW	332..361	CDD:366073	12/28 (43%)
		WW	407..435	CDD:366073
		WW	447..477	CDD:238122
		HECTc	516..868	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810