DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and HACE1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	941	Identity:	175/941 - (18%)
Similarity:	284/941 - (30%)	Gaps:	323/941 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 MQQQQQQMQE-----QRSKT-------PTALSETMPTEAAEAHEQEED---ESPMKLPYKFTRNP 437
            |::..:|:..     :|::|       .||:...||...|:.|....:   .|...:.|.|
Human     1 MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAF---- 61

  Fly   438 AELQGQRINTTLLKSSRGLGFTIVGSDGSA--------GGDVEEFLQIKTVVPNGPAWLDGQLQ- 493
                 .|:..:||.        |..:.||.        .|....:..|....|...|..:||.:
Human    62 -----GRVKRSLLH--------IAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKC 113

  Fly   494 -------TGDVLVYVND-------TCVLGYTH--HDMVNIFQSI----LPGERAALEVCR-GYPL 537
                   :.||.:..|:       ..|.|.|.  ||:|.....:    ..|:.|....|: |:..
Human   114 MSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKT 178

  Fly   538 PF--------DPNDPNTEVVTTM--AVDGRESDKQRRLNMDG--------NYNFLDLSGEGAKKT 584
            ..        |.|.||....|.:  |....:.|..:.|.:.|        ....|||..:|.
Human   179 TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG--- 240

  Fly   585 SGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRN------CCTQLME----- 638
            .|.....::...|.::...|   .|.....:.::...|:::.:..::      ..|.|.|
Human   241 YGETCEVLIQYHPRLFQTII---QMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTN 302

  Fly   639 GDVLLEI-NGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRK 702
            |..||.: :..:.:.|....:|.:.  |        .:.|..|..|:|.
Human   303 GHKLLSLSSNYDAQMKSLLRIVRMF--C--------HVFRIGPSSPSNG---------------- 341

  Fly   703 NFVGSGLFRSKTPTADLYST------QVKEVLPMRPKTPLVDTRRSRVQIQS------------- 748
              :..|...:|||.:.::..      .:.|.|.: ..|.|:..:|...:|.|
Human   342 --IDMGYNGNKTPRSQVFKPLELLWHSLDEWLVL-IATELMKNKRDSTEITSILLKQKGQDQDAA 403

  Fly   749 ------PNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTL 807
                  |......|.......|.||..|..:.::::..|::           ||..:.||:.| :
Human   404 SIPPFEPPGPGSYENLSTGTRESKPDALAGRQEASADCQDV-----------ISMTANRLSAV-I 456

  Fly   808 QGDANGGIYGMPPSMQP---LPLPLAHHESCYCY----------------DCQAQRYRPGYFVQA 853
            |.........|||.|..   :.....|.|...|:                :|.....|..:.::|
Human   457 QAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKA 521

  Fly   854 QQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANL---DPPQQMQHSPSWRNGALL 915
            |.                              ..||....:.:|   .|...|.|.|...|..||
Human   522 QP------------------------------FKDRCEWFYEHLHSGQPDSDMVHRPVNENDILL 556

  Fly   916 DVSEDA---DQCE-LTEVTLERQALGFGFRIVGGTEEG-SQVTVGH---IVPGGAADQDQRINTG 972
             |..|:   ..|| :::....:...|...|..|  ||| .|..|..   |:.....:.|..:.|
Human   557 -VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHG--EEGMGQGVVREWFDILSNEIVNPDYALFT- 617

  Fly   973 DEILSIDGINVLNSSHHKVVSLVGESALR-----GQVTMILRRRRTPLLQQAPVSTQLRRYPYDV 1032
               .|.||.....:|:    |.|....|.     ||:..:....|           ||
Human   618 ---QSADGTTFQPNSN----SYVNPDHLNYFRFAGQILGLALNHR-----------QL------- 657

  Fly  1033 IVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVN 1097
                             .|.|:..:..|.|.|.|               ||..::|.:......|
Human   658 -----------------VNIYFTRSFYKHILGIP---------------VNYQDVASIDPEYAKN 690

  Fly  1098 L-------IKESGLHVRLTI---------GVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQ-L 1145
            |       |.:.||.:..::         .||||     |||.|:.|:.|.         ||: :
Human   691 LQWILDNDISDLGLELTFSVETDVFGAMEEVPLK-----PGGGSILVTQNN---------KAEYV 741

  Fly  1146 SHQQQLPQQHLQQAQLNHHHQ--HLEMPMSM 1174
            ....:|......|.|:|...|  |:.:|.|:
Human   742 QLVTELRMTRAIQPQINAFLQGFHMFIPPSL 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570	24/120 (20%)
		DegQ	<455..534	CDD:223343	21/108 (19%)
		PDZ_signaling	606..668	CDD:238492	11/73 (15%)
		PDZ	925..1011	CDD:214570	21/95 (22%)
		PDZ_signaling	1029..1110	CDD:238492	14/87 (16%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	52/278 (19%)
		ANK 1	64..93		6/36 (17%)
		ANK repeat	66..95	CDD:293786	6/36 (17%)
		ANK	92..217	CDD:238125	25/124 (20%)
		ANK repeat	97..128	CDD:293786	6/30 (20%)
		ANK 2	97..126		6/28 (21%)
		ANK repeat	130..161	CDD:293786	6/30 (20%)
		ANK 3	130..159		6/28 (21%)
		ANK repeat	163..194	CDD:293786	6/30 (20%)
		ANK 4	163..192		5/28 (18%)
		ANK 5	196..226		5/29 (17%)
		ANK repeat	196..221	CDD:293786	4/24 (17%)
		ANK 6	228..257		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		6/34 (18%)
		HECTc	554..903	CDD:238033	63/294 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900