DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and HECW2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	628	Identity:	127/628 - (20%)
Similarity:	208/628 - (33%)	Gaps:	209/628 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQL-----APLNASHQHQHSHPHPHPHPVAAA 87
            |.|....|:....:.::...|..::.   :.:|:.|     :.|.|....:.....|.|.|.|..
Human   508 SLTSQTKLEDNPVENEEASTHEAASF---EDKPENLPELAESSLPAGPAPEEGEGGPEPQPSADQ 569

  Fly    88 TSFATFNGNSNLN---------SSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTLSSAGTDVVG 143
            .| |...|:..::         :|.|:|.||:.....:::|.|.:..::::.::....|.|:.|.
Human   570 GS-AELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVS 633

  Fly   144 NGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQ 208
            ..|                ..|.|...|                       :.|..|...|:.:|
Human   634 EAS----------------TRPEGESDL-----------------------ECADSSCNESVTTQ 659

  Fly   209 MSVHNQFISGLPS------NGIGSNGVHGGAATGR---GGPPNSILKGSKENLLQNTYYNGETGD 264
            :|..:...|.|.|      ....|.....||....   .||    .:||:|
Human   660 LSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGP----AEGSQE-------------- 706

  Fly   265 SSLGSECGVGDVQHQNHESHDDPGDG-----------LGPL----------------PPKWETAY 302
                |.|..|.:......|.:|.|.|           ||.:                ||:.|.:.
Human   707 ----SVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSA 767

  Fly   303 TE-----RGELYFIDHNTGTSH-----------WLDPRLSKYQKKSLEDCCEDELPYGWEKIEDS 351
            .|     .|.....:..||.|.           .:...:|:||:      .::.||..||...||
Human   768 GEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQR------VDEALPPNWEARIDS 826

  Fly   352 MYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAE 416
            ...::::|||||.|.::.|......:..::|...|||:|..::.|..| :|.|.......|.|.:
Human   827 HGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIR-RTMTNERPEENTNAID 890

  Fly   417 AHEQEEDESPMKLPYKFTRNPAELQGQRI--------NTTLLKSSRGLGFTIVGSDGSAGGDVEE 473
            ...:|.|         |.:..|:.:.:.|        ..|||..|..:.|.|          ..|
Human   891 GAGEEAD---------FHQASADFRRENILPHSTSRSRITLLLQSPPVKFLI----------SPE 936

  Fly   474 FLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTC-------VLGYTHH--------DMV---NIFQS 520
            |.   ||:.:.|:         ...::.|:||       |...|||        |:|   |:|.:
Human   937 FF---TVLHSNPS---------AYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 989

  Fly   521 ILPGERAALEVCRGYPLPFDPN------DPNTEVVTTMAVDGR 557
                  ..||:.||:.:..|..      |.|:.  ||..:|.|
Human   990 ------KQLELPRGWEMKHDHQGKAFFVDHNSR--TTTFIDPR 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	8/60 (13%)
		WW	342..372	CDD:238122	12/29 (41%)
		PDZ	443..534	CDD:214570	25/116 (22%)
		DegQ	<455..534	CDD:223343	20/96 (21%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073
		NESP55	<471..638	CDD:115071	26/149 (17%)
		PHA03169	591..>801	CDD:223003	47/270 (17%)
		WW	816..845	CDD:306827	12/28 (43%)
		WW	994..1023	CDD:306827	7/30 (23%)
		HECTc	1223..1577	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900