DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and SMURF1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_065162.1	Gene:	SMURF1 / 57154	HGNCID:	16807	Length:	757	Species:	Homo sapiens

Alignment Length:	388	Identity:	89/388 - (22%)
Similarity:	134/388 - (34%)	Gaps:	114/388 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SNLNSSLAN-GSSRKFNCSRDNVDDGGDAGEMAAASQT---LSSAGTDVVGNGSGHGNGTVTGNG 157
            ||..|.|.: |..|...|..:..|.....|::..:.||   :.:.|:.|...|.....|||.
Human   102 SNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVY--- 163

  Fly   158 EKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGLPSN 222
            |.||    ||    ||               .|...|:.|..:.::
Human   164 EDSG----PG----RP---------------LSCFMEEPAPYTDST------------------- 186

  Fly   223 GIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDP 287
                     |||.| ||....:...|::..||...........||.:.      |::.| .|..|
Human   187 ---------GAAAG-GGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTP------QNRPH-GHQSP 234

  Fly   288 GDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRL------------------------SKY 328
                 .||..:|...|.:|::||:...||.|.|.|||:                        |:.
Human   235 -----ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEP 294

  Fly   329 QKKSLEDCCE-DELPYGWEKIEDSMYG-MYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQ 391
            :..:..:|.| ..||.||| :..::.| :||:||.||.||:.:|.|             ..:...
Human   295 RDLNSVNCDELGPLPPGWE-VRSTVSGRIYFVDHNNRTTQFTDPRL-------------HHIMNH 345

  Fly   392 QQQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSR 454
            |.|::|.....|.....::..|...|...|.|   :....|..|:...||..:.....::.||
Human   346 QCQLKEPSQPLPLPSEGSLEDEELPAQRYERD---LVQKLKVLRHELSLQQPQAGHCRIEVSR 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	11/28 (39%)
		WW	342..372	CDD:238122	14/30 (47%)
		PDZ	443..534	CDD:214570	2/12 (17%)
		DegQ	<455..534	CDD:223343	89/388 (23%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028	9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..237		10/55 (18%)
		WW	236..267	CDD:197736	13/30 (43%)
		WW	307..339	CDD:197736	15/32 (47%)
		HECTc	399..754	CDD:238033	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900