DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and trip12

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	1072	Identity:	183/1072 - (17%)
Similarity:	308/1072 - (28%)	Gaps:	385/1072 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STAGGGAGVAARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQLAPLNASHQHQH 74
            |..||....:.|..|.|: |.|:.:..:.|.:|..|:                   .|:..:::.
Zfish     7 SNPGGSLRRSQRNTAAAQ-PIDHTLAGRLQPEQVNQK-------------------ANSPPENRR 51

  Fly    75 SHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTLSSAGT 139
            |:......|.::|..:|  .|:::..:||:.                 ..|.::.....|.:|||
Zfish    52 SNSKASKAPPSSAVGYA--RGHTSRRNSLSL-----------------SVGSLSIPDPDLEAAGT 97

  Fly   140 DVVGNGSGHGNGTVT------------------------------GNGEKSGGLAP--------- 165
               ....|...|:.|                              .:...||..||
Zfish    98 ---SGQQGRREGSSTRALKRSSVSEPNITFSPSPAKRPKVVSSHFSDSSASGPSAPAISPEVTEP 159

  Fly   166 ---PGGHHLR---------PPPPPALKKSASAVIGNSAS---------REDVASLSGTSSLNSQM 209
               |.....:         |.|..||.|.:|:..|.|.:         :.|...||.:||
Zfish   160 RKAPASVSTKSKKRRLAAEPAPARALSKKSSSYPGPSGASSTPSQKRKKADATLLSSSSS----- 219

  Fly   210 SVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVG 274
                   |.|||:...:..:...:...|...|..:...|..        :.:.|.|::.......
Zfish   220 -------SSLPSSSSAAGPLPPRSEASRAAKPTKLASKSAA--------SAKAGCSTVTDSSSSS 269

  Fly   275 DVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCED 339
            .....:..|......|.....|  :.|..::|:.......:.::....||.|...|       |.
Zfish   270 ASSSSSSSSSSSAATGTNSCAP--QGARLKQGKDQSKARRSRSASSPSPRRSSRDK-------EQ 325

  Fly   340 ELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPT 404
            ....|..|.:       :....|.:.....|.|.....|..::..:......|.::...|..|..
Zfish   326 SKAAGSSKFD-------WASRFNSKVNLPKPKLSLPGSAKAETSSKPGPSGLQAKLASLRKSTKK 383

  Fly   405 ALSETMPTE------------------------------AAEAHEQEE----DESPMKLPYKFTR 435
            . ||:.|.|                              ||||..||:    |.:.........|
Zfish   384 R-SESPPAELPSCRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADSDNNQDGANSSAAR 447

  Fly   436 NPAELQGQRINTTLLKSSRGLGFTIVG---SDGSAGGDVEEFLQIKTVVPN-----GPAW----- 487
            .....||...::::   :..:|.|..|   ||.|..|.::..|:.:.:.|:     ||..
Zfish   448 TEETPQGASASSSV---AGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPFGPRMSQLFH 509

  Fly   488 --------------LDGQLQTGD-------------VLVYVNDTCVLGYTHHDMVNIFQSILPGE 525
                          |.|...|||             :||..|:..:.|:.       .:|::|..
Zfish   510 RTIGSGASSKAQQLLQGLQATGDESQQLQAAIEMCQLLVMGNEETLGGFP-------VKSVVPAL 567

  Fly   526 RAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRES-----------DKQRRLNMDGNYNFLD---- 575
            ...|::...:.:   .|..:..:...|....|.|           :|.:.:      .|:|
Zfish   568 ITLLQMEHNFDI---MNHASRALTYMMEALPRSSAVVVDAIPVFLEKLQVI------QFIDVAEQ 623

  Fly   576 -------LSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIV--------- 624
                   ||...:|....:|.....:...|.::.:..:.::    .||.:.|..|.
Zfish   624 ALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNAL----AIAANCCQSITPDEFHFVAD 684

  Fly   625 -------------KKILDRNC-C---------------TQLMEGDVLLEINGLNVRNKP------ 654
                         ||.::..| |               .|:...|:|..|..|.|...|
Zfish   685 SLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASRDLLTNIQQLLVLTPPVLSSGM 749

  Fly   655 HFYVVELLK-ECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAK-LRKNFVGSG--------- 708
            ...||.:.. .||.....||::.:.                 |:|: ||....|:.
Zfish   750 FIMVVRMFSLMCSNCPCLAVQLMKQ-----------------NIAETLRFLLCGASNGSCQEQID 797

  Fly   709 -LFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQT 772
             :.||.....:|.|. :.|::|..|:                      ||..|..|..|....||
Zfish   798 LVPRSPQELYELTSL-ICELMPCLPR----------------------EGIFAVDAMLKKGSAQT 839

  Fly   773 QGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDAN-------GGIY-------------- 816
              ...:..|..||.....||   :|:..|:.|...|...:       |.:|
Zfish   840 --TEGAIWQWRDDRGLWHPY---NRIDSRIIETAHQNGEDEISLSTLGRVYTIDFNSMQQINEDT 899

  Fly   817 GMPPSMQPLPLPLAH-----HESCYCYDCQAQ 843
            |...::|..|.|||:     |......|.:||
Zfish   900 GTARAIQRKPNPLANPNTGGHLEVRREDARAQ 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	3/28 (11%)
		WW	342..372	CDD:238122	4/29 (14%)
		PDZ	443..534	CDD:214570	23/130 (18%)
		DegQ	<455..534	CDD:223343	23/118 (19%)
		PDZ_signaling	606..668	CDD:238492	19/106 (18%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
trip12	XP_005159283.1	WWE	842..907	CDD:280915	12/67 (18%)
		HECTc	1693..2094	CDD:238033
		HECTc	1711..2090	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900