DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and LOC564220

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_017212193.1	Gene:	LOC564220 / 564220	-ID:	-	Length:	1406	Species:	Danio rerio

Alignment Length:	907	Identity:	280/907 - (30%)
Similarity:	389/907 - (42%)	Gaps:	288/907 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMY 353
            |.|.|||..||.||||.|.:|||||||.::.||||||.| :.|..|.|.:.|||||||:|:|..|
Zfish   287 DSLEPLPYNWEMAYTETGMVYFIDHNTKSTTWLDPRLVK-KAKPPEKCEDGELPYGWEEIDDPQY 350

  Fly   354 GMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAH 418
            |.|::||:|:|||:||||:||||:....:....|.||:........:.||
Zfish   351 GTYYVDHINQRTQFENPVVEAKRKLGLDTAVATQTQQRAAPPPGGAAGTP--------------- 400

  Fly   419 EQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPN 483
                         .|||:|.:|:|:..:|.|.||.:|.||||:|.|.|     :||||:|.|:.:
Zfish   401 -------------GFTRDPTQLKGELYHTALRKSQQGFGFTIIGGDRS-----DEFLQVKNVLSD 447

  Fly   484 GPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFD-------- 540
            |||..|.::.:|||:|.:|.|.|||.||.|:|::||.|...:...:.:||||.||.|
Zfish   448 GPAAQDNKMASGDVIVEINGTLVLGKTHADVVHMFQCIPINQYVDMVLCRGYSLPPDVDADSEDL 512

  Fly   541 ---PNDPNTEVVTTM-AVDGR----ESDKQRRLNMDGNYNFLDLSG----------EGAKKTSGS 587
               |..|..|:||.: .::|:    :.|.....:.:.:|...|.||          ..|.....:
Zfish   513 PPPPPPPTGEIVTAVPLINGQPLLVKGDALHGSSQELHYVTTDASGRPVVAALPASSAANDRPET 577

  Fly   588 GSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRN 652
            |     |.:||:.:..|:||..||||.|||...||.||.|||...|..|::|||:.|||..||:.
Zfish   578 G-----MLQPELVSVPIVKGPGGFGFAIADCPLGQKVKMILDEQWCRGLLKGDVIKEINRQNVQT 637

  Fly   653 KPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTA 717
            ..|..||::||                 |.|..:.:       |:..||
Zfish   638 LSHAQVVDILK-----------------DLPVGSEV-------NLLVLR---------------- 662

  Fly   718 DLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQE 782
               ..|...|..:||:                                        |..::|.:.
Zfish   663 ---GGQTSPVKSLRPR----------------------------------------GGMSASTET 684

  Fly   783 LDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRP 847
            ||            |..:.:                      :|..|.:|
Zfish   685 LD------------RCHDMM----------------------VPQALTYH--------------- 700

  Fly   848 GYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHS--PSWR 910
                       |.|....||.|.|.|...:                      |:.:..|  |.::
Zfish   701 -----------SNTLPCSSPKQDASLHYSK----------------------PKALTESIVPQYK 732

  Fly   911 NGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEI 975
            .   |||....|           |..|||||::||......|.:|.|:|.|||:::.|:..|||:
Zfish   733 E---LDVFIKRD-----------QETGFGFRVLGGEGAEQPVYIGAIIPQGAAEKEGRLRAGDEL 783

  Fly   976 LSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR----------------------RTPLLQQ 1018
            :.||||.|...||.:|:.|:..:|..|||.:.:||:                      |.|.:|.
Zfish   784 IGIDGITVKGKSHKQVLDLMTNAARNGQVLLSVRRKVIFRDALEDVGSGALTLVNGSPRLPRIQV 848

  Fly  1019 APVSTQLRRYPYDVIVSRHENEGFGFVIISSSN------------HYYGSTIGKLIPGSPADRCG 1071
            ..|..|   ..:|:.:.|.:||||||||::|.:            |    .||::|.|||.||||
Zfish   849 PSVKDQ---ESFDITLHRRDNEGFGFVILTSKSKPPPGVCVSVIPH----KIGRIIEGSPTDRCG 906

  Fly  1072 ELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTP 1133
            .|.|||||.|||...|..:||.|:|.|||::|..|.||: ||..|....|.|:|....|..|
Zfish   907 LLNVGDRISAVNSQSIVELSHNDIVQLIKDAGNSVTLTV-VPEDEYKGPPSGASSAKQSPAP 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	18/28 (64%)
		WW	342..372	CDD:238122	19/29 (66%)
		PDZ	443..534	CDD:214570	39/90 (43%)
		DegQ	<455..534	CDD:223343	35/78 (45%)
		PDZ_signaling	606..668	CDD:238492	31/61 (51%)
		PDZ	925..1011	CDD:214570	33/85 (39%)
		PDZ_signaling	1029..1110	CDD:238492	42/92 (46%)
LOC564220	XP_017212193.1	PDZ_signaling	15..98	CDD:238492
		NK	120..>198	CDD:327404
		WW	291..323	CDD:197736	21/31 (68%)
		WW	338..367	CDD:306827	18/28 (64%)
		PDZ	412..498	CDD:214570	39/90 (43%)
		PDZ	589..664	CDD:214570	37/117 (32%)
		PDZ_signaling	733..817	CDD:238492	36/97 (37%)
		PDZ_signaling	857..946	CDD:238492	43/93 (46%)
		PDZ_signaling	1011..1084	CDD:238492
		Neuromodulin_N	<1182..>1365	CDD:331332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1337
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm24407
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000