DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and hecw1b

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_021336549.1	Gene:	hecw1b / 563730	ZFINID:	ZDB-GENE-060503-2	Length:	1555	Species:	Danio rerio

Alignment Length:	469	Identity:	99/469 - (21%)
Similarity:	145/469 - (30%)	Gaps:	176/469 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 NGSGHGNGT--VTGNGEKSGGLAPPG-GHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSL 205
            :|.||..|.  .||| ::|..|:|.. ..|:.|        .||..|  .|...|.|..|.::..
Zfish   623 DGDGHPLGAEGQTGN-QRSPDLSPVACCSHMSP--------RASGPI--RAQSLDSARRSESTVF 676

  Fly   206 NSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSE 270
            :||......                        ..||.||              |...::..|::
Zfish   677 SSQDDEDEM------------------------EQPNGIL--------------GSETETEQGAQ 703

  Fly   271 CGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWL-------------- 321
            |             .:||||    ..:||.|         .|.:..:.|.:
Zfish   704 C-------------REPGDG----SCQWEEA---------PDSHVQSPHGIVGNGEVAGPSGRRE 742

  Fly   322 ------DPRLSKYQKKSLE------DCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEA 374
                  .|.:|  |..:|.      ...::.||..||...||...::::||:||.|.::.|...|
Zfish   743 CPLPCNHPAVS--QLPALRPDPHHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPTSAA 805

  Fly   375 KRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAE 439
            ......:|...|||:|..::.|        .:..||.||..|    ||..||.......|...:.
Zfish   806 TPDGLRRSGSVQQMEQLNRRYQ--------TIQRTMATERRE----EESGSPRNDRTANTETDSP 858

  Fly   440 LQ------------GQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQL 492
            ||            |.....|||..|..:.|.          ...||.   ||:         ..
Zfish   859 LQTNELRRDTSCSPGHCQKITLLLQSPAVKFI----------THPEFF---TVL---------HA 901

  Fly   493 QTGDVLVYVNDTCVL--------------GYTHH-DMVNIFQSILPGERAALEVCRGYPLPFDPN 542
            ..|...::.|.:|:.              .|.|: |:|........   |.||:.||:.:..||.
Zfish   902 NYGAYRMFTNSSCLKHMVLKIRRDARNFERYQHNRDLVTFLNRFAD---AQLELPRGWEIKTDPQ 963

  Fly   543 ------DPNTEVVT 550
                  |.|:...|
Zfish   964 GKSFFVDHNSRATT 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	5/48 (10%)
		WW	342..372	CDD:238122	11/29 (38%)
		PDZ	443..534	CDD:214570	19/105 (18%)
		DegQ	<455..534	CDD:223343	15/93 (16%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
hecw1b	XP_021336549.1	HECW_N	73..192	CDD:318711
		C2_NEDL1-like	213..349	CDD:176073
		WW	771..803	CDD:197736	12/31 (39%)
		WW	952..983	CDD:197736	7/26 (27%)
		HECTc	1223..1552	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900