DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and smurf2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	366	Identity:	94/366 - (25%)
Similarity:	136/366 - (37%)	Gaps:	116/366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 VVGNGSG--HGNGTVTGNGE------------KSGGLAPPGGHHLRPPPPPALKKSASAVIG--- 188
            ||.:|||  |...||....:            ||..:.....:|.:     ..||..:..:|
Zfish    39 VVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKSDSITISVWNHKK-----IHKKQGAGFLGCVR 98

  Fly   189 ---NSASR-EDVASLSGTSSL-------NSQMSVHNQFISGLPS-NGIGSNG------------V 229
               ||.:| :|    :|...|       |...:|..|.:..|.| :.|||.|            :
Zfish    99 LLSNSINRLKD----TGYQRLDLNKLGPNDSDTVRGQIVVSLQSRDRIGSGGPVVDCSRLFDNDL 159

  Fly   230 HGG-----AATGR-------------------------GGPPNSILKGSKENLLQNTYYNGETGD 264
            ..|     .|:||                         .|.|.|.|......::......|...|
Zfish   160 PDGWEERRTASGRIQYLNHITRSTQWERPTRPASEYSSPGRPLSCLVDENTPIMTPNGAAGVPAD 224

  Fly   265 SSLGSECGVGDVQHQNHES----HDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRL 325
            .....|..|...:|:|:.|    |..|     .||..:|...|::|::||:...||.|.|.|||:
Zfish   225 DPRVQERRVRSQRHRNYMSRTHLHTPP-----DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRV 284

  Fly   326 SKYQKKSLEDC-CED--ELPYGWEKIEDSMYG-MYFIDHVNRRTQYENPVLEAK----------- 375
                .:.|.:. ||:  .||.||| |.::..| :||:||.||.||:.:|.|.|.
Zfish   285 ----PRDLSNVNCEELGPLPPGWE-IRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNPSPNG 344

  Fly   376 RRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSE-----TMP 411
            .|||.::|...:..|.::|.|...|  |..|.|     |:|
Zfish   345 SRAAVEAQSSSRPGQLKEQAQSVVS--PGNLPEDPECLTVP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	11/28 (39%)
		WW	342..372	CDD:238122	15/30 (50%)
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028	23/106 (22%)
		WW	159..188	CDD:278809	4/28 (14%)
		WW	252..283	CDD:197736	12/30 (40%)
		WW	298..330	CDD:197736	16/32 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		10/35 (29%)
		HECTc	410..762	CDD:238033
		HECTc	437..762	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900