Protein Alignment Magi and magi3a

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: NP_001352122.2
• Gene: magi3a / 561689
• ZFINID: ZDB-GENE-090312-48
• Length: 1355
• Species: Danio rerio
• Alignment Length: 1189
• Identity: 342/1189 - (28%)
• Similarity: 481/1189 - (40%)
• Gaps: 385/1189 - (32%)

  Fly   113 CSRDNVDDGGDAGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGG----HHLRP 173
            |:...:..|.:.||.....|.||.|....||...|.|:..:..||....||.....    .|.|
Zfish    29 CAVLEIRGGAEHGEFPHLGQVLSDALVCHVGRLPGPGDVLLEVNGTPVSGLTNRDTLAVIRHFR- 92

  Fly   174 PPPPALKKSASAVIGNSASREDVASLSGTSSLN---SQMSVHNQFISGLPSN----------GIG 225
             .|..||......:.|:..|..::......||:   .|:...|.::..:|..          |:.
Zfish    93 -EPLRLKTVKPGKVLNTDLRHYLSLQFQKGSLDHKLQQVIRDNLYLRTIPCTTRQPREGEVPGVD 156

  Fly   226 SN-------------------GVHGGAATGRGGPP------------------------------ 241
            .|                   |.:.|...|...||
Zfish   157 YNFISVGEFRVLEESGLLLESGTYDGNYYGTPKPPAEPSPVQPDLVDQVLFDEEFDAEVQRKRTT 221

  Fly   242 --------NSILKGSKENLLQNTYYNGET-----------------GDSSLGSECGVGDVQHQNH 281
                    :|.....:|...:....||.|                 ..||:       |.::.|.
Zfish   222 SVSKMDRKDSAAPEEEEEDERPPMVNGLTEHKEGPDWRKTVPSYTQSSSSM-------DFRNWNT 279

  Fly   282 ESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWE 346
            ...||..|   |||..||.||||.|.:||||||:.|:.||||||:| :.|..|.|.:.|||||||
Zfish   280 MPRDDSQD---PLPKNWEMAYTETGMVYFIDHNSKTTTWLDPRLAK-KAKPPEKCEDGELPYGWE 340

  Fly   347 KIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMP 411
            ||||..||.|::||:|::||:||||.|||::.::::                   :||    ..|
Zfish   341 KIEDPQYGTYYVDHINQKTQFENPVQEAKKKLSQET-------------------SPT----NQP 382

  Fly   412 TEAAEAHEQEEDESPMKLP------YKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGD 470
            |.||.|    ...:|...|      ..|||:|::|||..:.|||.||.:|.||||:|.|..
Zfish   383 TAAASA----AVAAPAAAPSGEVGLRGFTRDPSQLQGAILRTTLKKSPQGFGFTIIGGDRP---- 439

  Fly   471 VEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGY 535
             :||||:|.|:.:|||..|.::.:|||:|.:|..||||.||.|:|.:||||...:...:.:||||
Zfish   440 -DEFLQVKNVLRDGPAAHDNKIASGDVIVDINGACVLGKTHADVVQMFQSIPVNQYVDMVLCRGY 503

  Fly   536 PLPFDPN---DPNTEVVTTM-AVDGRESDKQRRLNMDGNYNFLDL---SGEG----AKKTSG--- 586
            |||.|.|   :...:::|.| .:||:.      :::||.....||   |.:|    |...:|
Zfish   504 PLPEDTNSSEEGTGDIMTAMPGMDGQP------IHLDGTAPLQDLHYMSADGRLPAAAMPNGRHP 562

  Fly   587 -SGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNV 650
             :|...:|  :||:.:..::||..||||.|||...||.||.|||...|..|::|||:.|||..||
Zfish   563 EAGESTLL--QPELVSVPLVKGPGGFGFAIADCPLGQKVKMILDAQWCRGLLKGDVIKEINRQNV 625

  Fly   651 RNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTP 715
            :...|..||::||                 |.|..:.:       ||..||..
Zfish   626 QTLSHAQVVDILK-----------------DLPVGSEV-------NVLVLRGG------------ 654

  Fly   716 TADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSL 780
                .::.||.:.|:.|..|:  |::..:                         :.|...|..:
Zfish   655 ----QTSPVKSLKPITPAMPI--TQKQDI-------------------------ITTSSISTDT- 687

  Fly   781 QELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRY 845
                      |.|         ||               |:.|.||.|
Zfish   688 ----------PSP---------AE---------------PAPQSLPFP----------------- 701

  Fly   846 RPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWR 910
                    .|...|.     ||                            .|||.:....|.:.:
Zfish   702 --------PQLIRSS-----SP----------------------------KLDPTELYLKSKAMQ 725

  Fly   911 NGALLDVSEDADQCELTEVTLER-QALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDE 974
            :...::..|       .:|.::| |..|||||::||......|.:|.|||.|||::|.|:..|||
Zfish   726 DSKPINTKE-------LDVFIKRNQETGFGFRVLGGEGPDQPVYIGAIVPLGAAEKDGRLRAGDE 783

  Fly   975 ILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRT------------------------PL 1015
            ::.|||:.|...||.:|:.|:..:|..|||.:.:||:.|                        |.
Zfish   784 LICIDGVPVKGKSHKQVLELMTNAARNGQVMLTVRRKLTFQDREEDDGVYPPAPQALSLVNGSPK 848

  Fly  1016 LQQAPVSTQLRRYPYDVIVSRHENEGFGFVIISSSN--------HYYGSTIGKLIPGSPADRCGE 1072
            .....||......||||.:.|.:||||||||::|.|        |    .||::|.|||.||.|.
Zfish   849 PSHVEVSGHSHPQPYDVTLQRKDNEGFGFVILTSKNKPPPGVIPH----KIGRIIEGSPTDRSGH 909

  Fly  1073 LKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTI--------GVPLKEGGPSPGGSSVGVS 1129
            |||||||.|||...|..:||.|:|.||||:|..|.||:        |..|:..||..|.||.
Zfish   910 LKVGDRISAVNGQSIIDLSHNDIVQLIKEAGNAVTLTVVPEEGELWGKYLEHSGPPSGTSSA--- 971

  Fly  1130 SNTPLQASPSLLKAQLSHQ 1148
                 :.||::....:..|
Zfish   972 -----KQSPAIQHRAMGQQ 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800	18/28 (64%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	39/88 (44%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	33/79 (42%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	35/84 (42%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	48/97 (49%)
magi3a	NP_001352122.2	None