DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and nedd4l

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	742	Identity:	156/742 - (21%)
Similarity:	251/742 - (33%)	Gaps:	221/742 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QQQQQQQQQQQHFNS-NHFYQQQQPQQL---------APLNASH--------QHQHSHPHPHPHP 83
            |.:|..|:..:.|.| .|..:..:.:||         .|::...        .|..|.|.....|
Zfish   513 QLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDDSWEPISEEDPTLLTDGLNHSLSGPSSLAMP 577

  Fly    84 VAAATSFATFNGNSNLNSSLA---NG-------------SSR-KFNCSRDNVDDGGDAGEMAAAS 131
            :   :|...|:...:|..|||   ||             ||| :.:...|.|.|.........:|
Zfish   578 L---SSTPDFSDEISLRLSLAPDTNGEIPGPSSAVQSHLSSRLRSSSMTDGVSDQAQPPTPTQSS 639

  Fly   132 QTLSSAGTDVVG---NGSGHGNGTVTGNGEKSGGLAPPGGHHLRPP----------------PPP 177
            ||..:....|.|   ..|...:..:|..|      .|||....:.|                ..|
Zfish   640 QTRRTRAQTVTGVEDTMSPSASYALTTPG------LPPGWEERKDPKGRTYYVNHNNRSTTWTRP 698

  Fly   178 ALKK-------SASAVIGNSASREDVASLSGTSS-------LNSQMSVHNQFISGLPSNGIGSNG 228
            .|::       ::.|.:|.:.:....||...|||       :....|:.:..:: |.|...|:|.
Zfish   699 ILQQHTEDGASTSVAAVGGATAATPPASTPSTSSGHLSEPQVRRPRSLSSPTVT-LSSPLEGANN 762

  Fly   229 VHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGP 293
            |          |....:|        :|:.|.::...|..|.   ...||:.::|.
Zfish   763 V----------PIRRAVK--------DTFSNPQSPQPSPYSS---PKTQHKANQSF--------- 797

  Fly   294 LPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKY-----QKKSLEDCCEDELPY-----GWEKI 348
            |||.||......|..:|||||:.|:.|.|||| ||     .|.||:......||.     |||:.
Zfish   798 LPPGWEMRIAPNGRPFFIDHNSRTTTWEDPRL-KYPVHMRTKASLDPGDLGPLPNLPEEPGWEER 861

  Fly   349 EDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTE 413
            ..:....::|||.|::||:|:|.|::...........::.:|:....:::..|         |.:
Zfish   862 VHADGRTFYIDHNNKKTQWEDPRLQSPAITGPAVPYSREFKQKYDYFRKKLKK---------PAD 917

  Fly   414 AAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTL-------------LKSSRGLGFTIVGSDG 465
            .           |.:...|..||....:..|...:|             .:|.:||.:
Zfish   918 I-----------PNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESEKGLDY------- 964

  Fly   466 SAGGDVEE-FLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAAL 529
              ||...| |..:...:.|....|.....|.:..:.:|...  |..:.|.::.|:.|  |..|.:
Zfish   965 --GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNS--GLCNEDHLSYFKFI--GRVAGM 1023

  Fly   530 EVCRGYPL------PFD----------------------------PNDPNTEVVTTMAVDGRESD 560
            .|..|..|      ||.                            .||| ||:.....:|  |.:
Zfish  1024 AVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDP-TELDLRFCID--EDN 1085

  Fly   561 KQRRLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGF--GFTIADSACGQI 623
            ..:...:|     |..||.....|:.:...:|.:.....:...:.|....|  |||       ::
Zfish  1086 FGQTYQVD-----LKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFT-------EL 1138

  Fly   624 VK----KILDRNCCTQLMEGDVLLEIN 646
            :.    ||.|.|....||.|...:::|
Zfish  1139 IPIDLIKIFDENELELLMCGLGDVDVN 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	13/28 (46%)
		WW	342..372	CDD:238122	12/34 (35%)
		PDZ	443..534	CDD:214570	20/104 (19%)
		DegQ	<455..534	CDD:223343	17/79 (22%)
		PDZ_signaling	606..668	CDD:238492	13/47 (28%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325
		WW	473..499	CDD:306827
		WW	669..698	CDD:306827	4/28 (14%)
		WW	798..829	CDD:197736	15/30 (50%)
		WW	856..885	CDD:238122	11/28 (39%)
		HECTc	946..1275	CDD:214523	48/248 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910