DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and WWC3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	928	Identity:	172/928 - (18%)
Similarity:	292/928 - (31%)	Gaps:	343/928 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 IDHVNRRTQYENP---------------------VLEAKRRAAEQSQQQ----QQMQQQQQQMQE 397
            :||:|:.||.|:|                     .|.||:...:..||:    |:..||..:|.|
Human     1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCE 65

  Fly   398 QRSKT-PTALSETMPTEAAEAHEQEED-----ESPMKLPYKFTRNPAELQGQRINT-TLLKSSRG 455
            ..|:: .::.|........:.|:.:.:     :...:|..:.|:...|||.:.... ||.:..|.
Human    66 DDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRK 130

  Fly   456 LGFTIVGSD-GSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVL-------------VYVNDTCV 506
            :..|..... ..|...:.|...||..:      ..|:.:..|::             ..|.|:.|
Human   131 MSSTHTSYKLDEAQAIMSELRTIKKAI------CTGEKERRDLMHSLAKLTDSFKNSCSVTDSLV 189

  Fly   507 LGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQR---RLNMD 568
             .:.||..|       ||:       .|.|..|......|:::.....|    ||.|   |:.::
Human   190 -DFPHHVGV-------PGD-------AGVPQQFCDAGSQTDIIGEFVFD----DKTRLVDRVRLN 235

  Fly   569 GNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCC 633
            ..|.      |..|:.:                 :|.:               |:.:  ||....
Human   236 WQYE------EARKRVA-----------------NIQQ---------------QLAR--LDNESW 260

  Fly   634 TQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVA 698
            ....|.|          |::     ::|:||..........|            :||....|:||
Human   261 PSTAEAD----------RDR-----LQLIKEKEALLQELQLI------------IAQRRSAGDVA 298

  Fly   699 KLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAA 763
            :|.:.                 ..:::|.|           ||:|                |.:|
Human   299 RLEEE-----------------RERLEEEL-----------RRAR----------------ATSA 319

  Fly   764 ERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGG-------------- 814
            :....::..|.|.|..|.:|::...:..|.:....|...:.:|:...::.|
Human   320 QGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRG 384

  Fly   815 ---------IYGMPPSMQP------------LPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAM 858
                     |||:|...:|            :|......::.:                ::....
Human   385 SLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPF----------------SEPPGP 433

  Fly   859 SGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSED--- 920
            ||...|...|.|.           ..|.|...|...::|.||.....:|      .|..|.|
Human   434 SGFHKQRRSLDTP-----------QSLASLSSRSSLSSLSPPSSPLDTP------FLPASRDSPL 481

  Fly   921 ---ADQCE------LTEVTLERQALGFGFRIVGGTEE--GSQVTVGHIVPGGAADQDQRINTGDE 974
               ||.||      |..:.....|:        |.|:  |......|.|||......:|
Human   482 AQLADSCEGPGLGALDRLRAHASAM--------GDEDLPGMAALQPHGVPGDGEGPHER------ 532

  Fly   975 ILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQAPVSTQLRRYP-------YDV 1032
                 |....::.....|:|..:||.|     :.||.|.       :|..|..|.       ::.
Human   533 -----GPPPASAPVGGTVTLREDSAKR-----LERRARR-------ISACLSDYSLASDSGVFEP 580

  Fly  1033 IVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELK-VGDRIVAVNRIEI---AGMSHG 1093
            :..|:|:         :....||.|...   |.|....|.|: .|...:.|:.:::   ||::
Human   581 LTKRNED---------AEEPAYGDTASN---GDPQIHVGLLRDSGSECLLVHVLQLKNPAGLA-- 631

  Fly  1094 DVVNLIKES-GLHVRLTIGVPLKEGGPSPGGS-----SVGVSSN----TPLQASPSLLKA-QL-- 1145
                 :||. .:|:|:.: .||..|.|:...|     .|.:..|    .|:.:|...||: ||
Human   632 -----VKEDCKVHIRVYL-PPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYV 690

  Fly  1146 -SHQQQLPQQHLQQAQLN 1162
             |...||.::.|..||:|
Human   691 CSVTPQLQEELLGIAQIN 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122	7/34 (21%)
		PDZ	443..534	CDD:214570	18/105 (17%)
		DegQ	<455..534	CDD:223343	15/92 (16%)
		PDZ_signaling	606..668	CDD:238492	9/61 (15%)
		PDZ	925..1011	CDD:214570	18/93 (19%)
		PDZ_signaling	1029..1110	CDD:238492	17/92 (18%)
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	23/114 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		17/98 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		7/44 (16%)
		C2_Kibra	602..725	CDD:176062	31/115 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900