DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and HERC6

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	331	Identity:	58/331 - (17%)
Similarity:	112/331 - (33%)	Gaps:	102/331 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 SGFILMKKPEIYTFSIMKGSMGFGFTIADSACG------QIVKKI------LDRNCCTQLMEGDV 641
            |.|:|:  ||.......|.........|.:.|.      |::||.      ...|...|:::..:
Human   492 SVFLLL--PECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAI 554

  Fly   642 LLEINGLNVRNKPHFYVVELL---KECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKL--- 700
            :.::.......:.|..|..||   ||..:......::    |:    ||. .:|::.|:...
Human   555 ISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRL----PE----NTF-NINELSNLLNFYID 610

  Fly   701 --RKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAA 763
              |:.|..:.|..::||:..::|           ..|.:....|::::...::.:..:     .:
Human   611 RGRQLFRDNHLIPAETPSPVIFS-----------DFPFIFNSLSKIKLLQADSHIKMQ-----MS 659

  Fly   764 ERKPLQLQTQGKSNSSLQELDDIPYMDPYPKI------SRLSERLAEVTLQGDA----------- 811
            |:|...|..:    :.||:.|:.|   |.|:.      |||.:.......|.:|
Human   660 EKKAYMLMHE----TILQKKDEFP---PSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEF 717

  Fly   812 -------NGGI----------------YGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQA 853
                   :||:                |||  .|.|      ...||..:..:.:..:..||:..
Human   718 INEICPESGGVSSEFFHCMFEEMTKPEYGM--FMYP------EMGSCMWFPAKPKPEKKRYFLFG 774

  Fly   854 QQAAMS 859
            ....:|
Human   775 MLCGLS 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492	14/76 (18%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274
		RCC1_2	89..118	CDD:290274
		RCC1	105..155	CDD:278826
		RCC1	158..208	CDD:278826
		RCC1	215..263	CDD:278826
		RCC1_2	250..279	CDD:290274
		RCC1	266..313	CDD:278826
		HECTc	684..1026	CDD:238033	17/105 (16%)
		HECTc	711..1026	CDD:214523	12/78 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900