DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	827	Identity:	162/827 - (19%)
Similarity:	280/827 - (33%)	Gaps:	229/827 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 LPPKWETAYTERGELYFIDHNTGTSHWLDP-----RLSKYQKKSLEDCCEDELPYGWEKIEDSMY 353
            ||..|....|..|.::||:....::.||.|     .::.::::|      .:||.|||:......
Human    12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQS------TDLPTGWEEAYTFEG 70

  Fly   354 GMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAH 418
            ..|:|:|..|:...::||      ..:.||........:|               |:.|..:|
Human    71 ARYYINHNERKVTCKHPV------TGQPSQDNCIFVVNEQ---------------TVATMTSE-- 112

  Fly   419 EQEEDESPMKL-----PYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIK 478
              |:.|.|:.:     .|..|.:.|......:..|...|.:      |.:.|.....::.
Human   113 --EKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKK------VHNFGKRSNSIKR----- 164

  Fly   479 TVVPNGP----AWLDGQLQTGDVL-----VYVNDTCVLGYTHHDMVNIFQSI-LPGERAAL---- 529
              .||.|    .||..|..||..|     ..::|.|:..|.......|..|| ||..:.||
Human   165 --NPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSE 227

  Fly   530 -EVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDG-------------NYNFLDLSGEG 580
             .:.|.|  .|....||..........|:|.:...:..:|.             |:....::.|.
Human   228 DHINRKY--AFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSEN 290

  Fly   581 A--KKTSGSGSGFILMKKPEI----------------------YTF-------------SIMKGS 608
            |  |:|:...:..:|: ||||                      |.|             |:...|
Human   291 APTKETNNIPNHRVLI-KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 354

  Fly   609 MGFGFTIADSAC-GQIV-----------KKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVEL 661
            :...:. :.||| .|.|           .||::.:          |.::.|.|..|....|
Human   355 LPSEYE-SGSACPAQTVHYRPINLSSSENKIVNVS----------LADLRGGNRPNTGPLY---- 404

  Fly   662 LKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGS-GLFRSKTPTADLYSTQVK 725
                   |.....||||       |::.||.|...:.|.|.:...: |:...:|...::.|.:.:
Human   405 -------TEADRVIQRT-------NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQ 455

  Fly   726 ---------EVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQ 781
                     ..||...|     ||...:...:|:......|.| |..:|:.::..|..:    |.
Human   456 IMARYPEGYRTLPRNSK-----TRPESICSVTPSTHDKTLGPG-AEEKRRSMRDDTMWQ----LY 510

  Fly   782 ELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYR 846
            |.....:.:....:.|.|...:..|:...::..::.:|.|        ..|.|...|    |.|.
Human   511 EWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTS--------PSHGSIAAY----QGYS 563

  Fly   847 PGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRR---VNELLSDRRRVGFANLD----PPQQMQ 904
            |      |:...|..:   ||:|...:..:|..|.   .:..:.|||.|. |.|.    .||.:|
Human   564 P------QRTYRSEVS---SPIQRGDVTIDRRHRAHHPKHVYVPDRRSVP-AGLTLQSVSPQSLQ 618

  Fly   905 -HSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQR 968
             .:|  ....||.:.....|.||:.:.....|.....::...:.:..  .:.|.:.......|.:
Human   619 GKTP--EELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNE--ILSHHLQRNTIYLDHQ 679

  Fly   969 INTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPL 1015
            :...:.|:::            |.:::..||||.|:.....|:::.:
Human   680 MKENEPIITM------------VHTMIENSALRPQLYQQFLRQKSKI 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	9/28 (32%)
		WW	342..372	CDD:238122	9/29 (31%)
		PDZ	443..534	CDD:214570	23/105 (22%)
		DegQ	<455..534	CDD:223343	21/93 (23%)
		PDZ_signaling	606..668	CDD:238492	13/73 (18%)
		PDZ	925..1011	CDD:214570	12/85 (14%)
		PDZ_signaling	1029..1110	CDD:238492
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809	9/28 (32%)
		WW	58..87	CDD:278809	9/28 (32%)
		PH_PEPP1_2_3	164..267	CDD:270068	27/111 (24%)
		PH	170..266	CDD:278594	23/97 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900