DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Wwc2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	1206	Identity:	230/1206 - (19%)
Similarity:	376/1206 - (31%)	Gaps:	475/1206 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 GDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSM 352
            |.|..|||..||.|....|::::|||||..:.|:|||....:..|..||..||||:|||...|..
Mouse     6 GSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70

  Fly   353 YGMYFIDHVNRRTQYENP----------------------------------------------- 370
            .|.|:|||:|:.||.|:|
Mouse    71 IGAYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRL 135

  Fly   371 ---------------------------VLEA---------KRRAAEQSQQQQQMQQQQ------Q 393
                                       :|:|         |:...|.|..:|::..:|      |
Mouse   136 NDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTQLRVKKLKRELSHMKQELLYKQQGFETLQ 200

  Fly   394 QMQEQRS---------KTPTALSETMPTEAA----EAHEQEEDESPMKLPYKF-------TRNPA 438
            |:.|:.|         :....|:|......|    |..:|:..:|..||..:|       :..|
Mouse   201 QIDEKMSGGQSGYELNEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEP- 264

  Fly   439 ELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDV------------------EEF------LQIKT 479
            :|:...:|:.|..|.:.|.   .||..|..||:                  ||.      |:|:.
Mouse   265 DLRSSPVNSHLSLSRQTLD---AGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIEL 326

  Fly   480 VVPNGPAWLDGQLQ-TGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEV------------ 531
            ...:|.|| .|.|. ..:.|:.:|:       ..:::...|.|.|.:|:..|:
Mouse   327 SKLDGEAW-PGALDIEKEKLMLINE-------KEELLKELQFITPQKRSQEELERLEAERQHLEE 383

  Fly   532 ----CRGYP-------LPFDPND-------PNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDL-S 577
                .||.|       |..:...       ..|..:||......:|.....|:|....:...| |
Mouse   384 ELMAARGSPSRALTERLKLEEKRKELLQKLEETTKLTTSLYSQLQSLSSSTLSMSSGSSLGSLAS 448

  Fly   578 GEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVL 642
            ..|:..||..|| ...:...|:|..|  :|..                  :|.:...:|   |.|
Mouse   449 SRGSLNTSSRGS-LNSLSSSELYYSS--QGDQ------------------MDTDYQYKL---DFL 489

  Fly   643 LEINGLNVRNKP--HFYVVELLKECSQ----------------TTPTAVKIQRTPPDPPANNTLA 689
            |:..|..:.:.|  ..:..|::|..||                ||| ..:..::.....:.::|:
Mouse   490 LQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCGVGVTASSHTTP-LTEASKSVASLSSRSSLS 553

  Fly   690 QLNQVGNVAKLRKNFVGSGLFRS--KTPT-----------ADL---------------------- 719
            .|:..|:...|...|.||....|  :.||           ||:
Mouse   554 SLSPPGSPLVLDSVFPGSSHDTSPHQFPTDFEDCELSRRFADVGLGENQALLDSDSGGASQPLLE 618

  Fly   720 --------------YSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQL 770
                          .:|.|::.||.|....|...:.:||...:.:..|..:.....|:.::|
Mouse   619 DKGLSDCPGELLCEGATDVEKSLPKRRGLHLRGDKTTRVSAAASDESVAGDSGVYEASMKQP--- 680

  Fly   771 QTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDA-------------NGGIYGMPPS- 821
                      .|::|:||.:....|...::  .::.|:.|.             |...:.:|.|
Mouse   681 ----------GEMEDVPYSEEDVTIVETAQ--VQIGLRYDTKSSSFMVIIAQLRNLHAFSIPHSS 733

  Fly   822 ---MQPLPLPLAHHESCYCY-----DCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERI 878
               .:...||.:...||...     ..::..|...:.|...|||:...|.:......:..:.|..
Mouse   734 KVYFRVALLPSSADVSCLFRTKVHPPTESVLYNDVFRVAVSQAALQQKTLRVDLCSASKHRREEC 798

  Fly   879 QRRVNELLSDRRRVGFA--------NLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQA 935
            .......|:|   :.|:        ||.|.:||   |..:|       ||
Mouse   799 LAGTQISLAD---LPFSNEIFMLWYNLLPSKQM---PCKKN-------ED--------------- 835

  Fly   936 LGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQ------------RINTGDEILSIDGINVLNSSH 988
                     |.||          ||..:.|..            ...|..|:|:::
Mouse   836 ---------GNEE----------PGARSQQPMLDPIDLDAVSALLARTSAELLAVE--------- 872

  Fly   989 HKVVSLVGESALRGQ--------VTMI---------LRRRRTPLLQ------------QAPVSTQ 1024
            .::.....|..||.:        :||:         ||....||.:            :.|.::|
Mouse   873 QELAQEEEEEELRPERRGPGRDCLTMLREASDEPAALRESGVPLAEGSRCTEDPKPCPRGPETSQ 937

  Fly  1025 LRRYPYD----------VIVSRHENEGFGFVI-------------ISSSNHYY--GSTIGKLIPG 1064
            .|:.|.:          .:|.:..|.  ..|:             :||..|.:  .|.|.:....
Mouse   938 CRKEPAEDPGQLPSGLPTLVDKETNT--DEVVDSNMAVRPKDRSSLSSRQHPFVRNSVIVRSQTF 1000

  Fly  1065 SPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKES----------GLHVRLTIGVP-LKEGG 1118
            ||.:|      ...|..:||      |..|...|.|:|          .|.|:..:..| |:.
Mouse  1001 SPGER------SQYICRLNR------SDSDSSTLAKKSLFVRNSTERRSLRVKRAVCQPTLRR-- 1051

  Fly  1119 PSPGGSSVGVSSNTPLQASPSL---LKAQLSHQQQL 1151
                     .:...|::.|..|   |:|.|:.|.:|
Mouse  1052 ---------TAQECPVRTSLDLELDLQASLTRQSRL 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	15/103 (15%)
		PDZ	443..534	CDD:214570	25/131 (19%)
		DegQ	<455..534	CDD:223343	22/119 (18%)
		PDZ_signaling	606..668	CDD:238492	12/79 (15%)
		PDZ	925..1011	CDD:214570	16/114 (14%)
		PDZ_signaling	1029..1110	CDD:238492	22/115 (19%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809	12/28 (43%)
		WW	59..88	CDD:278809	15/28 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		7/26 (27%)
		C2_Kibra	699..822	CDD:176062	19/127 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849		9/59 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963		14/88 (16%)
		Phage_Nu1	<1088..>1146	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900