DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and UBR5

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1109	Identity:	209/1109 - (18%)
Similarity:	369/1109 - (33%)	Gaps:	305/1109 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IITATTTSTAGGGAGVAA-----RGVATAKSPTDYLMLQQQQQQQQQQQQHF----------NSN 52
            ::||.|..:..|.:.|.|     ...:...|.:|    ....|....:|:.|          ||:
Human  1642 VVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSD----SSSSQSDDIEQETFMLDEPLERTTNSS 1702

  Fly    53 H---FYQQQQPQQLAPLNASHQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCS 114
            |   ..|..:..|.|..|..||...|.........||:::...:...|||..|....:|.....:
Human  1703 HANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAA 1767

  Fly   115 RDNVDDGGDAGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPAL 179
                     |.|.:.||..|:||      :........|........||.|...|.:....|.|:
Human  1768 ---------ALEASNASSYLTSA------SSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAV 1817

  Fly   180 KKSASAVIG--NSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPN 242
            |.:....:.  |....:.:.:.:...|:........::.|.|             |:.|..|.||
Human  1818 KLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSAL-------------ASAGDPGHPN 1869

  Fly   243 SILKGSKENLLQNTY----------YNGETGDSSLGSECGV----GDVQHQNH-----ESHDDPG 288
            ..|..|:.:..:...          ..|....:.|.:..|:    ||  ..|:     .||:|..
Human  1870 HPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGD--FLNYALSLMRSHNDEH 1932

  Fly   289 DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMY 353
            ..:.|:                                      |:.|....:.|.::.:
Human  1933 SDVLPV--------------------------------------LDVCSLKHVAYVFQAL----- 1954

  Fly   354 GMYFIDHVNRRTQYENPVLEAK--RRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAE 416
             :|:|..:|::|..:.|.||.|  |...|.....:..:.:......|.:.......:::|.|..:
Human  1955 -IYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQ 2018

  Fly   417 AHE--QEEDE---------SPMKLP----YKFTRNPAELQGQRINTTLL-KSSRGLGFTIVGSDG 465
            .|.  :..|.         :|.::|    ......|..||.......|. :.|:|| ::...|.|
Human  2019 NHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGL-YSSSASSG 2082

  Fly   466 SAGGDVEEFLQIKTVVPNGPAWL----------DGQLQTGD---VLVYVNDTCVLGYTHHDMVNI 517
            ....:|........|:|...::.          :.|.:.|:   ||....::...|.:.||:...
Human  2083 KCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQ 2147

  Fly   518 FQSILPGERAALEVCRGYPL-PFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNF-LDLSGEG 580
            .:|.|..| ..|....|.|| .|.|......:|.:..:            :.|.:.. |:|.|..
Human  2148 LKSSLLAE-IGLTESEGPPLTSFRPQCSFMGMVISHDM------------LLGRWRLSLELFGRV 2199

  Fly   581 AKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLME----GDV 641
            ..:..|:..|.||.:             :| ||.:.:|...:.::|:.::......:|    .|:
Human  2200 FMEDVGAEPGSILTE-------------LG-GFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDL 2250

  Fly   642 LLEINGLNVRNKPHFYVVELLKECSQTTPTAV-KIQRTPPDPPANNTLAQLNQVGNVAKLRKNFV 705
            |::.....:.|  ||.     :.|: |||.|| :::.|..|.|..
Human  2251 LIQQTMRQLNN--HFG-----RRCA-TTPMAVHRVKVTFKDEPGE-------------------- 2287

  Fly   706 GSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPN--------NEVDDEGDGAAA 762
            |||:.||       :.|.:.:......|.|.::.      ||:.|        ..:.:.|:....
Human  2288 GSGVARS-------FYTAIAQAFLSNEKLPNLEC------IQNANKGTHTSLMQRLRNRGERDRE 2339

  Fly   763 AERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPL 827
            .||:....::.|....|.::.|    .|...::| :..|......:|:         ||..|.||
Human  2340 REREREMRRSSGLRAGSRRDRD----RDFRRQLS-IDTRPFRPASEGN---------PSDDPEPL 2390

  Fly   828 PLAHHESCYCYDCQAQRYRPGYFVQAQQAAM-SGTTGQYSPLQTAHL-----QNERIQRRVNE-- 884
            | ||.::.      .:|..|.  |||.|.|. |..||....|..|.|     ..:.::.||:|
Human  2391 P-AHRQAL------GERLYPR--VQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAM 2446

  Fly   885 --LLSDRRRVGFANL------DPPQQMQHSPSWRNGAL-------LDVSEDADQCELTEVTLERQ 934
              :::..|..|..::      |..:::|.....|:|:.       ||.::|.|         :..
Human  2447 ELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGD---------DNA 2502

  Fly   935 ALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNS-------SHHKVV 992
            .|.:        :.|.:   |...|....:.:.|:|....|..|.|:.:|.:       :.|.:.
Human  2503 PLFY--------QPGKR---GFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIK 2556

  Fly   993 SLVG 996
            .|:|
Human  2557 VLLG 2560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	0/28 (0%)
		WW	342..372	CDD:238122	6/29 (21%)
		PDZ	443..534	CDD:214570	20/104 (19%)
		DegQ	<455..534	CDD:223343	18/91 (20%)
		PDZ_signaling	606..668	CDD:238492	12/65 (18%)
		PDZ	925..1011	CDD:214570	13/79 (16%)
		PDZ_signaling	1029..1110	CDD:238492
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740		22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		3/36 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		16/83 (19%)
		PolyA	2389..2452	CDD:197769	21/71 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		3/19 (16%)
		HECTc	2501..2796	CDD:214523	13/71 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900