DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and HERC5

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	656	Identity:	123/656 - (18%)
Similarity:	194/656 - (29%)	Gaps:	261/656 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 SLNSQMSVHNQF-----------ISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTY 257
            :|:.|:.|..:|           ::|:|...|.:...|..|.:..|                |.|
Human   316 NLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSG----------------NIY 364

  Fly   258 YNGETGDSSLGSECGVGDVQHQNHESHDDPG-------------------------DGL------ 291
            ..|:       :|||...:.|.  ||.|||.                         |||
Human   365 SWGK-------NECGQLGLGHT--ESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGA 420

  Fly   292 ------------GPLPP-----------------KWET-AY-TERGELYFIDH-------NTGTS 318
                        ..|.|                 :|.| || ::.|:::....       |.||.
Human   421 GKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTR 485

  Fly   319 HWLDP---RLSKYQKKSLED-CCEDEL---PYG------WEKIEDSMYGMYFIDHVN-RRTQYEN 369
            ..|.|   ::|..::..||. ..|.||   ..|      |.|.|:|        :|| :||   .
Human   486 DQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENS--------YVNLKRT---I 539

  Fly   370 PVLE---AKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPY 431
            |.|.   .||..|:  .:.::.|..::::||..| :|..|     |.:.....:..:..|:.|..
Human   540 PTLNEGTVKRWIAD--VETKRWQSTKREIQEIFS-SPACL-----TGSFLRKRRTTEMMPVYLDL 596

  Fly   432 KFTRNPAELQGQR-----INTTLLKSS--RGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPA--- 486
            ...||..:...|:     :.||.||.:  :.|.|         ....:|.|:|..::|..|.
Human   597 NKARNIFKELTQKDWITNMITTCLKDNLLKRLPF---------HSPPQEALEIFFLLPECPMMHI 652

  Fly   487 -----------------------------WLDGQLQTGDVLVYVNDT---CVLGYTHHD------ 513
                                         |...|..|...||.:..|   |.|.|....
Human   653 SNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWDESAEENGN 717

  Fly   514 ---MVNIFQSILPGER-------AALEVCRGYPLPFDPNDPNT-------EVVTTMAVDGRESDK 561
               ::.:.:.:...::       ||:|..|.......|....|       |.|..........|.
Human   718 VQALLEMLKKLHRSKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDL 782

  Fly   562 QRRLNMDGNYNFLDLSGE-----GAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADS--- 618
            ::.|       ::..|||     |..|.......|..|.:||...|...:|:....|.:...
Human   783 RKEL-------WVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEK 840

  Fly   619 --------ACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKI 675
                    .||                     |.:...||.|.|  :.:.|.|:.....|:...:
Human   841 KRYFFFGVLCG---------------------LSLFNCNVANLP--FPLALFKKLLDQMPSLEDL 882

  Fly   676 QRTPPD 681
            :...||
Human   883 KELSPD 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	11/54 (20%)
		WW	342..372	CDD:238122	10/36 (28%)
		PDZ	443..534	CDD:214570	24/148 (16%)
		DegQ	<455..534	CDD:223343	19/129 (15%)
		PDZ_signaling	606..668	CDD:238492	11/72 (15%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
HERC5	XP_011530324.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900