DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Magi2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006535806.1	Gene:	Magi2 / 50791	MGIID:	1354953	Length:	1414	Species:	Mus musculus

Alignment Length:	1226	Identity:	361/1226 - (29%)
Similarity:	511/1226 - (41%)	Gaps:	409/1226 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HGNGTVTG------------NGEKSGGLAPPGGHH------LRPP--PPPALKKSASAVIGNSAS 192
            |..|.|.|            ..||||.|...|.:.      .:||  |.|.|..:...:.|.:.|
Mouse   145 HKEGEVPGVDYIFITVEEFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLNVTDQILPGATPS 209

  Fly   193 RE------------DVASLSGTSSLNSQMSVHNQFISGLPSNGI---GSNGVHGGAATGRGG--- 239
            .|            :.||:........:..|.|       .||:   ..:..|...:.|..|
Mouse   210 AEGKRKRNKSVTNMEKASIEPPEEEEEERPVVN-------GNGVVITPESSEHEDKSAGASGETP 267

  Fly   240 --PPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAY 302
              |..:.:....|.|...                 :.|.:....|.::|.    .|||..||.||
Mouse   268 SQPYPAPVYSQPEELKDQ-----------------MDDTKPTKPEENEDS----DPLPDNWEMAY 311

  Fly   303 TERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQY 367
            ||:||:|||||||.|:.||||||:| :.|..|:|.|:|||||||||:|.:||.|::||:|||||:
Mouse   312 TEKGEVYFIDHNTKTTSWLDPRLAK-KAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQF 375

  Fly   368 ENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYK 432
            |||||||||:          :||......|..:|         |.:|....|:     |:
Mouse   376 ENPVLEAKRK----------LQQHNMPHTELGAK---------PLQAPGFREK-----PL----- 411

  Fly   433 FTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDV 497
            |||:.::|:|..::|||.||:.|.||||:|.|     :.:||||:|:|:|:|||..||:::||||
Mouse   412 FTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD-----EPDEFLQVKSVIPDGPAAQDGKMETGDV 471

  Fly   498 LVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMA--------- 553
            :||:|:.||||:||.|:|.:|||:..|:...|.:||||||||||.||...:|..:|
Mouse   472 IVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVM 536

  Fly   554 VDGRE-------------------------------SDKQRRLNMDGNY------NFLDLSGEGA 581
            |:||.                               :|.|    :||.|      :.:.::..||
Mouse   537 VNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQ----LDGTYPPPVHDDNVSMASSGA 597

  Fly   582 KKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEIN 646
            .:.             |:.|.:|:||:.|||||||||..||.||:|||...|..|.|||:::|||
Mouse   598 TQA-------------ELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEIN 649

  Fly   647 GLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFR 711
            ..||:|..|..||::||:|...:.|::.|.|                             .|.|.
Mouse   650 QQNVQNLSHTEVVDILKDCPVGSETSLIIHR-----------------------------GGFFS 685

  Fly   712 SKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKS 776
                             |.:...|::|                              :.:.||..
Mouse   686 -----------------PWKTPKPMMD------------------------------RWENQGSP 703

  Fly   777 NSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQ 841
            .:||                                    ..|...|.||.|.|.|.|.:
Mouse   704 QTSL------------------------------------SAPAVPQNLPFPPALHRSSF----- 727

  Fly   842 AQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHS 906
                             ..:|..:.|.:....:.....|.:.|   .|::|      ||
Mouse   728 -----------------PDSTEAFDPRKPDPYELYEKSRAIYE---SRQQV------PP------ 760

  Fly   907 PSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINT 971
               |....:| |...|..|| :|.|.|...||||||:||.|.|..:.:|.::..|:||:|.|::.
Mouse   761 ---RTSFRMD-SSGPDYKEL-DVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHP 820

  Fly   972 GDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR----------------------RTP 1014
            |||::.:|||.|...:|..|:.|:..:|..|||.:.:||:                      .:|
Mouse   821 GDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSP 885

  Fly  1015 LLQQAPVSTQLRRYP-----------------YDVIVSRHENEGFGFVIISSSNH-YYGST---- 1057
            ....|..|......|                 .||::.|.||||||||||||.|. ..|:|
Mouse   886 RSDYATYSNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGATITVP 950

  Fly  1058 --IGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKE---- 1116
              ||::|.|||||||.:|||||||:|||...|..|.|.|:|.|||::||.|.|.| :|.:|
Mouse   951 HKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRI-IPQEELNSP 1014

  Fly  1117 -GGPSPGGSSVGVSSNTPL-------QASPSLLKAQLSHQQQLPQQHLQ-QAQLNHHHQHL---- 1168
             ..||....|.....::||       |.||:...:.::  |..|.|.|| |...|.:...:
Mouse  1015 TSAPSSEKQSPMAQQHSPLAQQSPLAQPSPATPNSPVA--QPAPPQPLQLQGHENSYRSEVKARQ 1077

  Fly  1169 ---------------EMPMSMPVPGHGSYLERP--------SNNISATLALHQQPQ 1201
                           :.|:....|..|.|.:.|        .:.....|:.::|||
Mouse  1078 DVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPPPLDYRQHSPDTRQYPLSDYRQPQ 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	20/28 (71%)
		WW	342..372	CDD:238122	21/29 (72%)
		PDZ	443..534	CDD:214570	45/90 (50%)
		DegQ	<455..534	CDD:223343	40/78 (51%)
		PDZ_signaling	606..668	CDD:238492	35/61 (57%)
		PDZ	925..1011	CDD:214570	36/85 (42%)
		PDZ_signaling	1029..1110	CDD:238492	51/104 (49%)
Magi2	XP_006535806.1	PDZ_signaling	22..96	CDD:238492
		NK	118..290	CDD:388413	31/168 (18%)
		WW	303..332	CDD:366073	20/28 (71%)
		WW	349..378	CDD:366073	20/28 (71%)
		PDZ	427..508	CDD:214570	44/85 (52%)
		PDZ	601..682	CDD:214570	41/109 (38%)
		MAGI_u5	681..755	CDD:374709	21/181 (12%)
		PDZ	774..860	CDD:214570	36/86 (42%)
		PDZ_signaling	919..1006	CDD:238492	51/87 (59%)
		PDZ_signaling	1138..1218	CDD:238492
		MAGI_u1	1245..1285	CDD:374706
		PHA03307	<1255..>1407	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6556
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm42887
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	LDO	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860