Protein Alignment Magi and Magi1

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: XP_038964101.1
• Gene: Magi1 / 500261
• RGDID: 1586025
• Length: 1491
• Species: Rattus norvegicus
• Alignment Length: 1125
• Identity: 367/1125 - (32%)
• Similarity: 497/1125 - (44%)
• Gaps: 370/1125 - (32%)

  Fly   228 GVHGGAATGRGGPP--------------NSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQH 278
            |.:.|...|...||              :|:..|||::..:.|        .|.......|.|..
  Rat   180 GTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRT--------KSYNDMQNAGIVHT 236

  Fly   279 QNHESHD--------------------------------------DPG------------DGLGP 293
            :|.|..|                                      ||.            |.|||
  Rat   237 ENEEEEDVPEMNSSFTADSGDQDEPTLQEATLPPVNSSALAAPITDPSQKFPQYLPLSAEDNLGP 301

  Fly   294 LPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCED-------------ELPYGW 345
            ||..||.||||.||:|||||||.|:.|||||....|:|.||:|.:|             |||.||
  Rat   302 LPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEEGVHTEELDSELELPAGW 366

  Fly   346 EKIEDSMYGMYFIDHVNRRTQYENPVLEAKR-RAAEQSQQQQQMQQQQQQMQEQRSKTPTALSET 409
            |||||.:||:|::||:||:|||||||||||| |..||.|||||.|||.||.|..:.:..|....:
  Rat   367 EKIEDPVYGVYYVDHINRKTQYENPVLEAKRKRQLEQQQQQQQHQQQPQQPQPPQPEEWTEDHAS 431

  Fly   410 MPTEAAEAHEQEEDESPMKLPYK----FTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGD 470
            :....|.:|.....|...:.|.:    |||||:||:|:.|:|.|.|||||.|||:||.|     :
  Rat   432 VVPPVAPSHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGD-----E 491

  Fly   471 VEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGY 535
            .:||||||::|.:|||.|||:::||||:|.||||||||:||..:|.|||||..|....||:||||
  Rat   492 PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGY 556

  Fly   536 PLPFDPNDPNTEVVTTMA--------VDGRE--------SDKQRRLNMDGNYNFLDL-SGEGAKK 583
            ||||||:||||.:||::|        |:|:|        |.|..:::     |..|. ....|..
  Rat   557 PLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVS-----NMKDARPSSPADV 616

  Fly   584 TSGSGSGF---------ILMKKPEIYTFSIMKGSMGFGFTIADS--ACGQIVKKILDRNCCTQLM 637
            .|.|..|:         .:..:||:.|..|:||.||||||||||  ..||.||:|:|...|..|.
  Rat   617 ASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLK 681

  Fly   638 EGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQR--------TPPDPPANNTLAQLNQV 694
            |||:::|:|..||:...|..||::|.||.:.:...:.:||        :|...|.....:|.:..
  Rat   682 EGDLIVEVNKRNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746

  Fly   695 GNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDG 759
            .:|:.||.       ..:.:|:   :|.||      .|:.|..|       :.:|     |:.|.
  Rat   747 HSVSSLRS-------LHTASPS---HSAQV------LPEYPPAD-------VPAP-----DQTDS 783

  Fly   760 AAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQP 824
            :...:..|.::..|.:|                                      :|...| |.|
  Rat   784 SGQKKPDPFKIWAQSRS--------------------------------------MYENRP-MSP 809

  Fly   825 LPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDR 889
            .|                               .||.:           :.|| .|.:|
  Rat   810 SP-------------------------------ASGLS-----------KGER-DREIN------ 825

  Fly   890 RRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCEL-----TEVTLERQALGFGFRIVGGTEEG 949
                                        |.:..:|::     .::.|.|:..||||||:||.|.|
  Rat   826 ----------------------------STNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPG 862

  Fly   950 SQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRR---- 1010
            ..:.:|||||.||||.|.|:.:|||::.:||..|:..||..||.|:.::|.:|.|.:.:||
  Rat   863 EPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 927

  Fly  1011 ----------------------------RRTPLLQQ------------------------APVST 1023
                                        :|||...|                        ..||.
  Rat   928 TVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSA 992

  Fly  1024 QLRRYPYDVIVSRHENEGFGFVIISS-SNHYYGST------------IGKLIPGSPADRCGELKV 1075
            .|:  ||||.:.|.|||||||||:|| |....|:|            ||::|.||||||||:|||
  Rat   993 VLQ--PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKV 1055

  Fly  1076 GDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASPSL 1140
            ||||:|||...|...||.|:||||||:|..|.|.|         .||..|   |:.|.|..:..:
  Rat  1056 GDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI---------IPGDES---SNATLLTNAEKI 1108

  Fly  1141 LKAQLSHQQQLPQQHLQQAQ 1160
            .....:|...  ||..|:.:
  Rat  1109 ATITTTHAPS--QQGTQETR 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800	20/28 (71%)
		WW	342..372	CDD:238122	21/29 (72%)
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	51/88 (58%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	37/81 (46%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	37/88 (42%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	53/94 (56%)
Magi1	XP_038964101.1	PDZ0_MAGI-1_3-like	14..103	CDD:467212
		NK	122..293	CDD:450170	18/120 (15%)
		WW	302..331	CDD:459800	20/28 (71%)
		WW	362..393	CDD:197736	22/30 (73%)
		PDZ1_MAGI-1_3-like	470..554	CDD:467213	51/88 (58%)
		PDZ2_MAGI-1_3-like	639..722	CDD:467214	38/82 (46%)
		MAGI_u5	728..805	CDD:465224	20/142 (14%)
		PDZ3_MAGI-1_3-like	839..923	CDD:467215	37/83 (45%)
		PDZ4_MAGI-1_3-like	996..1092	CDD:467216	54/104 (52%)
		PDZ5_MAGI-1_3-like	1150..1232	CDD:467217