DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and magi1b

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_005155886.1	Gene:	magi1b / 474349	ZFINID:	ZDB-GENE-030131-5110	Length:	1625	Species:	Danio rerio

Alignment Length:	1170	Identity:	377/1170 - (32%)
Similarity:	519/1170 - (44%)	Gaps:	350/1170 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EKSGGLAPPG---GHHLRPPPPPALKKSASAVIGNSASREDVASLSG--------TSSLNSQMSV 211
            |:||.|...|   |::...|.||....|...:.|::.  :|  ||.|        |.|.|...:
Zfish   166 EQSGTLLEIGSYEGNYYGTPKPPIKPPSGKVITGDAL--QD--SLPGSQPSTPRRTKSYNEMQN- 225

  Fly   212 HNQFISGL-PSNGIGSNGV--HGGAATGRGGPPN---SILKGSKENL----LQNTYYNGETGDSS 266
                 :|: |:.....:.|  ...:.||....|:   |:...:::.|    |.||  :..|.:||
Zfish   226 -----AGIVPTETEDDDEVPEMNSSFTGDSSEPDDHPSVRPFARDQLQPYGLNNT--SASTTESS 283

  Fly   267 LGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKK 331
            ..:.      .|..:.:.:||   |||||..||.||||.||:|||||||.|:.|:|||.....:|
Zfish   284 QNTH------THPAYPTEEDP---LGPLPENWEMAYTENGEVYFIDHNTKTTSWIDPRCLDKPQK 339

  Fly   332 SLEDCCED------------ELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKR-RAAEQSQ 383
            .||:|.:|            |||.|||||:|.:||:|::||:||:||||||:||||| :..||||
Zfish   340 PLEECEDDEGVHTEELDNELELPTGWEKIDDPVYGVYYVDHINRKTQYENPILEAKRKKQLEQSQ 404

  Fly   384 QQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEEDES-----PMKLPYK-----FTRNPA 438
            ..:..:..|:.:.|..|..|.|      :.||...|...|..     |.:|..|     ||||||
Zfish   405 PAEGERFIQEWIDEHSSGAPLA------SYAANHQETYRDPGTGPPLPTQLGAKRGKPFFTRNPA 463

  Fly   439 ELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVND 503
            ||:|..|||.|.||.||.|||:||.|     :.:||||||::|.:|||.|||:::||||:|.|||
Zfish   464 ELKGTFINTKLKKSRRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVND 523

  Fly   504 TCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMD 568
            ||||||||..:|.|||||..|....||:||||||||||:||||.:||::|:..:|.     :.::
Zfish   524 TCVLGYTHAQVVKIFQSIPIGSMVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP-----IIVN 583

  Fly   569 GNYNFLDLSGEGAKKTSGSGS-----------------------GF---------ILMKKPEIYT 601
            |..::...|..|::.|:|..|                       |:         .:..:||:.|
Zfish   584 GKESYDSPSSHGSETTAGGSSLNGSSDPPRPHSPSAEVASNGSHGYPSDVVTLASSIATQPELIT 648

  Fly   602 FSIMKGSMGFGFTIADSAC--GQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKE 664
            ..:.||..|||||||||..  ||.||:|:|...|..|.|||:::|:|..||:|..|..||:||.:
Zfish   649 VHMEKGDKGFGFTIADSPSGGGQRVKQIVDYPRCRGLREGDIIMEVNKRNVQNLTHNQVVDLLSK 713

  Fly   665 CSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLP 729
            |.:.:...:.:||                  .||..:|:
Zfish   714 CPKGSEVTMLVQR------------------GVAPAKKS-------------------------- 734

  Fly   730 MRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDP-YP 793
              ||...:                          |||    .:||.|..|:.....|....| :.
Zfish   735 --PKLQQL--------------------------ERK----DSQGSSQHSVSSQRSIHTDSPLHA 767

  Fly   794 KISRLSERLAEVTLQGDANGGIYGMPPSMQPLP-LPLAHHESCYCYDCQAQRYRPGYFVQAQQAA 857
            ..:.|:|..|.              ||..|||| ||                         |...
Zfish   768 SQALLNESAAP--------------PPPSQPLPSLP-------------------------QDPP 793

  Fly   858 MSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDAD 922
            :.||                :|::.               ||.:....|.|.....|.|..|.
Zfish   794 VDGT----------------LQKKP---------------DPFKIWAQSRSMYESRLPDYQEQ-- 825

  Fly   923 QCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSS 987
                 ::.|.|:..||||||:||.|.|..:.:||||..||||:|.|:.:|||::.:||..|:..|
Zfish   826 -----DIFLWRKDTGFGFRILGGNEPGEPIYIGHIVKYGAADEDGRLRSGDELICVDGTAVVGKS 885

  Fly   988 HHKVVSLVGESALRGQVTMILRRRR-------------TPLLQ-----QAPVSTQLRR------- 1027
            |..||.|:.::|.:|.|.:.:||:.             :|...     |||..|:.:|
Zfish   886 HQLVVQLMQQAAKQGHVNLTVRRKTGYGLAKVDGEMPPSPASSHHSSTQAPSLTEEKRTPQGSQN 950

  Fly  1028 --------------------------------YPYDVIVSRHENEGFGFVIISS-SNHYYGST-- 1057
                                            .||||.:.|.|||||||||:|| |....|:|
Zfish   951 SLNTVSSGSGSTSGIGSGGGGGSNNTVIPNAILPYDVEIQRGENEGFGFVIVSSVSRPEAGTTFA 1015

  Fly  1058 ----------IGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGV 1112
                      ||::|.||||||||:|||||||:|||...|...||.|:||||||:|..|.|.|
Zfish  1016 GNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI-- 1078

  Fly  1113 PLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQLSHQQQLPQQHLQQAQLNHHHQHLEMPMSMPVP 1177
                   .||..|...|..|..:...::.......||..|:.. ...:........:.|.:.|.|
Zfish  1079 -------IPGDESSNASLLTNAEKIATITTTHTPQQQAAPEPR-NNTKPKQESFEFKAPQAPPPP 1135

Fly 1178 1177
Zfish 1136 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	19/28 (68%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ	443..534	CDD:214570	53/90 (59%)
		DegQ	<455..534	CDD:223343	46/78 (59%)
		PDZ_signaling	606..668	CDD:238492	33/63 (52%)
		PDZ	925..1011	CDD:214570	37/85 (44%)
		PDZ_signaling	1029..1110	CDD:238492	53/93 (57%)
magi1b	XP_005155886.1	PDZ_signaling	17..95	CDD:238492
		NK	117..>242	CDD:302627	21/85 (25%)
		WW	301..332	CDD:197736	21/30 (70%)
		WW	361..390	CDD:278809	19/28 (68%)
		PDZ	473..554	CDD:214570	50/85 (59%)
		PDZ	645..727	CDD:214570	37/99 (37%)
		MAGI_u5	726..818	CDD:293271	34/237 (14%)
		PDZ_signaling	832..907	CDD:238492	34/74 (46%)
		PDZ_signaling	984..1079	CDD:238492	54/103 (52%)
		PDZ_signaling	1150..1228	CDD:238492
		DUF1777	1353..>1456	CDD:285811
		PRP38_assoc	1369..1453	CDD:289628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1337
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm24407
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000