DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and Smurf

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	99/433 - (22%)
Similarity:	152/433 - (35%)	Gaps:	99/433 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITATTT---------STAGGGAGVAARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQ 59
            ::||||         |::.||..:..|......:||       ........:.|.|.||.
  Fly   280 VSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPT-------SSTTSASVRLHSNDNHV----- 332

  Fly    60 PQQLAPLNASHQHQ-HSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGD 123
                    .:.:|| :.|..|...|.:........|||:...|:..|||              |.
  Fly   333 --------KTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGS--------------GQ 375

  Fly   124 AGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIG 188
            |.:..:||            ||....:...|.:  .|...:||  .|.:.||.|.:...||.
  Fly   376 AAQPQSAS------------NGWTQEDAATTTS--PSTTTSPP--RHSQSPPTPNISPPASV--- 421

  Fly   189 NSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLL 253
                         |.|.|.  :||:...:..|:...|.:..:..|..|:.....|..:..:|:..
  Fly   422 -------------TPSANG--NVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESST 471

  Fly   254 QNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGP---LPPKWETAYTERGELYFIDHNT 315
            :.....|.....:.|...|.|..|.....:.........|   |||.:|...|::|::||....|
  Fly   472 RRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPT 536

  Fly   316 GTSHWLDPRLSK-YQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENP-----VLEA 374
            |.|.|.|||:.: :..:.|.......||.|||:.:.:...:||:||.||.||:.:|     :|:.
  Fly   537 GVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQM 601

  Fly   375 KRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEA 417
            .||..            ........:.||...|.|..|.:|.|
  Fly   602 IRRGT------------VPPTSAANAGTPAPPSATPATPSAAA 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	13/34 (38%)
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	14/31 (45%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810