DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and Hectd1

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus


Alignment Length:1296 Identity:224/1296 - (17%)
Similarity:366/1296 - (28%) Gaps:494/1296 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TATTTSTAG-----------------GGAGVAARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSN 52
            |:|.|:..|                 |.:...:.|:.:..|| |...:.:...::...|:..:|:
  Rat  1448 TSTLTAETGSENAERKLGPDSSVRAPGESSAISMGIVSVSSP-DVSSVSELTNKEAASQRPLSSS 1511

  Fly    53 HFYQQQQPQQL---APLNASHQHQHSHPHPHPHPVAAATSF-------ATFNGNSNLNSSLANGS 107
            ...:......|   ||:::|    .|.|:......::..||       |..|..:|:|.|.::..
  Rat  1512 ASNRLSVSSLLAAGAPMSSS----ASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSD 1572

  Fly   108 SRKFNCSRD----------------NVDDGGDAG--EMAAASQTLSS---AGTDVVGNGSGHGNG 151
            :......|:                |:...|...  .|:.:|.|.||   ..|.|:..|....|.
  Rat  1573 NNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNT 1637

  Fly   152 TVTG----NGEKSGG-------------------LAPPGGHHLRPPPP----------------- 176
            ..|.    :.|...|                   ||........|.|.                 
  Rat  1638 LTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYE 1702

  Fly   177 -------PALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSN-----GV 229
                   |:|::.|       .||.||...:.||.|       .|..||..|..||..     ..
  Rat  1703 EVMILRRPSLQRRA-------GSRSDVTHHAVTSQL-------PQVPSGAGSRPIGEQEEEEYET 1753

  Fly   230 HGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPL 294
            .||..  |....:.:||.....|:           .:.....|..:||.........||.....|
  Rat  1754 KGGRR--RTWDDDYVLKRQFSALV-----------PAFDPRPGRTNVQQTTDLEIPPPGTPHSEL 1805

  Fly   295 PPKWETAYTERGELYFIDHNTGTSHWLDPRLSK-------YQKKSLEDCC-----EDELPYGWEK 347
            ..:.|...:.|..|.......||:..::..||.       |.:|.|:..|     .|:|...||.
  Rat  1806 LEEVECTPSPRLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEP 1870

  Fly   348 IEDSMY---------------GMYFIDHVNRRTQY------------------------------ 367
            ....||               |.:.|:||.   ||                              
  Rat  1871 TYTIMYREMKDSDKEKENGKMGCWSIEHVE---QYLGTDELPKNDLITYLQKNADAAFLRHWKLT 1932

  Fly   368 -ENPVLEAKRRAAE-------------------------QSQQQQQMQQQQQQMQEQRSKTPTAL 406
             .|..:...|..::                         ||.....:.::|.|.:....:.|..:
  Rat  1933 GTNKSIRKNRNCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGNGQNPCGV 1997

  Fly   407 SETMP------TEAAEAH----EQEEDESPMKLPYKFTRNPAELQGQRINTTLLK---------- 451
            .:.:.      ..|::.:    :::.||.|     :||..|.|...::|.|.:|:          
  Rat  1998 EDVLQLLRILYIVASDPYSRISQEDGDEQP-----QFTFPPDEFTSKKITTKILQQIEEPLALAS 2057

  Fly   452 --------------------SSRGLGFTIVGSDGSAG-----------------------GDVEE 473
                                .:|.|.||......|..                       .|..|
  Rat  2058 GALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGE 2122

  Fly   474 F----LQIKTV-VPNGPA---WLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERA--- 527
            |    |:.:.| ||.|.:   |.:..:|                .|.|..::.:....||..   
  Rat  2123 FRVGRLKHERVKVPRGESLMEWAENVMQ----------------IHADRKSVLEVEFLGEEGTGL 2171

  Fly   528 --ALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSG 590
              .||........|.    .|::.|.:..|....|:.|.:::.|.                    
  Rat  2172 GPTLEFYALVAAEFQ----RTDLGTWLCDDNFPDDESRHVDLGGG-------------------- 2212

  Fly   591 FILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPH 655
               :|.|..|               ...:||......        ..:.|.|..|..|.     |
  Rat  2213 ---LKPPGYY---------------VQRSCGLFTAPF--------PQDSDELERITKLF-----H 2246

  Fly   656 FYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLY 720
            |..:.|.| |.|.....        |.|.:....:|..:|::   :.|.  |.|........||:
  Rat  2247 FLGIFLAK-CIQDNRLV--------DLPISKPFFKLMCMGDI---KSNM--SKLIYESRGDRDLH 2297

  Fly   721 STQVKE------------------------VL-PMRPKTP-------------LVDTRRSRVQIQ 747
            .|:.:.                        :| |.:||.|             ||:..|:|..  
  Rat  2298 CTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFL-- 2360

  Fly   748 SPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDAN 812
               .|:.|     .|.:|:      |...|.||.|             ...:.:|.|:.|:..:.
  Rat  2361 ---KEIKD-----LAIKRR------QILGNKSLSE-------------DEKNTKLQELVLKNPSG 2398

  Fly   813 GGIYGMPP-SMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNE 876
            .|    || |::.|.|......|...|...|...:|.  .:.:...|.... :|..|......:.
  Rat  2399 SG----PPLSIEDLGLNFQFCPSSRIYGFTAVDLKPS--GEDEMITMDNAE-EYVDLMFDFCMHT 2456

  Fly   877 RIQRRVNELLSDRRRVGFANLDPPQQM--------------QHSPSWRNGALLDVSEDADQCELT 927
            .||:::...     |.||..:.|.:::              ..||||....:::.:|       .
  Rat  2457 GIQKQMEAF-----RDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTE-------P 2509

  Fly   928 EVTLERQALGF--GFRIVGGTEEGS-----QVTVG--HIVPGGAADQDQRINTGDEILSID 979
            ::...|.:.||  ..|::.|.....     |.|.|  .:.|||.|:...|:....::.:.|
  Rat  2510 KLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATD 2570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 6/28 (21%)
WW 342..372 CDD:238122 11/75 (15%)
PDZ 443..534 CDD:214570 24/156 (15%)
DegQ <455..534 CDD:223343 20/114 (18%)
PDZ_signaling 606..668 CDD:238492 11/61 (18%)
PDZ 925..1011 CDD:214570 14/64 (22%)
PDZ_signaling 1029..1110 CDD:238492
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560
ANK repeat 366..393 CDD:293786
ANK 369..479 CDD:238125
ANK repeat 396..426 CDD:293786
ANK repeat 428..457 CDD:293786
F5_F8_type_C 1107..1240 CDD:304887
MIB_HERC2 1277..1335 CDD:284184
HECTc 2131..2608 CDD:238033 103/573 (18%)
HECTc 2155..2607 CDD:214523 95/533 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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