DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Hace1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006256657.1	Gene:	Hace1 / 361866	RGDID:	1306114	Length:	916	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	174/941 - (18%)
Similarity:	285/941 - (30%)	Gaps:	316/941 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 MQQQQQQMQE-----QRSKT-------PTALSETMPTEAAEAHEQEED---ESPMKLPYKFTRNP 437
            |::..:|:..     :|::|       .||:...||...|:.|....:   .|...:.|.|
  Rat     1 MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAF---- 61

  Fly   438 AELQGQRINTTLLKSSRGLGFTIVGSDGSA--------GGDVEEFLQIKTVVPNGPAWLDGQLQ- 493
                 .|:..:||.        |..:.||.        .|....:..|....|...|..:||.:
  Rat    62 -----GRVKRSLLH--------IAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKC 113

  Fly   494 -------TGDVLVYVND-------TCVLGYTH--HDMVNIFQSI----LPGERAALEVCR-GYPL 537
                   :.||.:..|:       ..|.|.|.  ||:|.....:    ..|:.|....|: |:..
  Rat   114 MSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKT 178

  Fly   538 PF--------DPNDPNTEVVTTM--AVDGRESDKQRRLNMDG--------NYNFLDLSGEGAKKT 584
            ..        |.|.||....|.:  |....:.|..:.|.:.|        ....|||..:|.
  Rat   179 TVQCLLDSGADINRPNVAGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG--- 240

  Fly   585 SGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGL- 648
            .|.....::...|.::...:.       .|..:.....:::::|..  .:|..|...|..:.||
  Rat   241 YGQTCEVLIQYHPRLFQTIVQ-------MTQNEDLRENMLRQVLQH--LSQQSESQYLKILTGLA 296

  Fly   649 ---NVRNKPHFYVVELLKECSQTTPTAVK-----------IQRTPPDPPANNTLAQLNQVGNVAK 699
               .........|..|:...|.:....:|           :.|..|..|:|.  ..:...||...
  Rat   297 EVATTNGHKLLSVFRLVSSLSSSYEAQMKSLLRIVRIFCHVFRIGPSSPSNG--MDMGYNGNKTP 359

  Fly   700 LRKNF----------------VGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQS 748
            ..:.|                :.:.|.::|..:||:.|..:|:              :.:.|..|
  Rat   360 RSQVFKPLELLWHSLDEWLVLIATELMKNKEDSADITSILLKQ--------------KGQDQEAS 410

  Fly   749 PNNEVDDEGDGA------AAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTL 807
            ..:..:..|.|:      ...|.||..|..:.::::..|::           ||..:.||:.| :
  Rat   411 CISAFEPPGPGSYERLSTGPGESKPDVLAGKQEASADCQDV-----------ISVTANRLSAV-I 463

  Fly   808 QGDANGGIYGMPPSMQP---LPLPLAHHESCYCY----------------DCQAQRYRPGYFVQA 853
            |.........|||.|..   :.....|.|...|:                :|.....|..:.::|
  Rat   464 QAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKA 528

  Fly   854 QQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANL---DPPQQMQHSPSWRNGALL 915
            |.                              ..||....:.:|   .|...|.|.|...|..||
  Rat   529 QP------------------------------FKDRCEWFYEHLHSGQPDSDMVHRPVSENDILL 563

  Fly   916 DVSEDA---DQCEL-TEVTLERQALGFGFRIVGGTEEG-SQVTVGH---IVPGGAADQDQRINTG 972
             |..|:   ..||: ::....:...|...|..|  ||| .|..|..   |:.....:.|..:.|
  Rat   564 -VHRDSIFRSSCEIVSKANCAKLKQGIAVRFHG--EEGMGQGVVREWFDILSNEIVNPDYALFT- 624

  Fly   973 DEILSIDGINVLNSSHHKVVSLVGESALR-----GQVTMILRRRRTPLLQQAPVSTQLRRYPYDV 1032
               .|.||.....:|:    |.|....|.     ||:..:....|           ||
  Rat   625 ---QSADGTTFQPNSN----SYVNPDHLNYFRFAGQILGLALNHR-----------QL------- 664

  Fly  1033 IVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVN 1097
                             .|.|:..:..|.|.|.|               ||..::|.:......|
  Rat   665 -----------------VNIYFTRSFYKHILGIP---------------VNYQDVASIDPEYAKN 697

  Fly  1098 L-------IKESGLHVRLTI---------GVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQ-L 1145
            |       |.:.||.:..::         .||||     |||.|:.|:.|.         ||: :
  Rat   698 LQWILDNDISDLGLELTFSVETDVFGAMEEVPLK-----PGGGSILVTQNN---------KAEYV 748

  Fly  1146 SHQQQLPQQHLQQAQLNHHHQ--HLEMPMSM 1174
            ....:|......|.|:|...|  |:.:|.|:
  Rat   749 QLVTELRMTRAIQPQINAFLQGFHMFIPPSL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570	24/120 (20%)
		DegQ	<455..534	CDD:223343	21/108 (19%)
		PDZ_signaling	606..668	CDD:238492	10/65 (15%)
		PDZ	925..1011	CDD:214570	21/95 (22%)
		PDZ_signaling	1029..1110	CDD:238492	14/87 (16%)
Hace1	XP_006256657.1	ANK repeat	66..95	CDD:293786	6/36 (17%)
		ANK	66..93	CDD:197603	6/34 (18%)
		Ank_2	69..194	CDD:289560	25/132 (19%)
		ANK	92..217	CDD:238125	25/124 (20%)
		ANK repeat	97..128	CDD:293786	6/30 (20%)
		ANK repeat	130..161	CDD:293786	6/30 (20%)
		Ank_2	135..222	CDD:289560	19/86 (22%)
		ANK repeat	163..194	CDD:293786	6/30 (20%)
		ANK repeat	196..221	CDD:293786	4/24 (17%)
		Ank_4	199..249	CDD:290365	10/52 (19%)
		HECTc	561..910	CDD:238033	63/294 (21%)
		HECTc	586..909	CDD:214523	57/268 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900