DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Ufd4

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1146	Identity:	209/1146 - (18%)
Similarity:	357/1146 - (31%)	Gaps:	437/1146 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 AAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSAS 192
            ||.::..:|.||::..|...:....|..:|:::                     ::.:.:|:|
  Fly  1780 AAIARRRTSQGTNIQDNQIMNAEANVNEHGDQN---------------------ASGSFLGHS-- 1821

  Fly   193 REDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTY 257
               |.||       .::::.:.|.|||.|             |.:..|  |:...:.||:..:..
  Fly  1822 ---VTSL-------VKLALSSNFHSGLLS-------------TAQSYP--SLSSNNSENIAPSNP 1861

  Fly   258 YNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHN-----TGT 317
            .|...|..|..:                                         |:|.     |.|
  Fly  1862 SNTSAGQQSAST-----------------------------------------INHTLTMSLTST 1885

  Fly   318 SHWLDPRLSKYQKKSLED---CCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAA 379
            |       |..::.||||   .|......|....||.|      |..|...:.|:
  Fly  1886 S-------SDSEQVSLEDFLESCRAPALLGDLDDEDDM------DEDNDEEENED---------- 1927

  Fly   380 EQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAE-------AHEQEEDESPMKLPYK----- 432
                :.:::.....|:...|:     |...|..||.|       ..:..:||..:|..:.
  Fly  1928 ----EYEEVGNTLLQVMVSRN-----LLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPA 1983

  Fly   433 FTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEE--FLQIKTVVPNGPAWLDGQLQTG 495
            |...|..   ..:|.|.......||..:.....|.|.:..|  .|.:|.   .||.  .|.:...
  Fly  1984 FDPRPGR---TNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKL---RGPG--IGGIPEV 2040

  Fly   496 DVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESD 560
            ::               |:.|...:|.   ||..|:.:...|                   .:.|
  Fly  2041 EI---------------DLSNTDWTIF---RAVQELLQCSQL-------------------NKLD 2068

  Fly   561 KQRRLNMDGNYN--FLDLSGEGAKKT--------------SGSGSGFILMKKPEIYTFSIMKGSM 609
            |.|:: .:..|.  :.::|.|..:.|              |.||:..:....|           |
  Fly  2069 KFRKI-WEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSP-----------M 2121

  Fly   610 GFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRN-----KPHFYVVELLKECSQTT 669
            ..||.:||:            |.|:.....::|.:|||||...     |.|...| |.::...:.
  Fly  2122 HIGFNVADN------------NLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSV-LSEDLFISK 2173

  Fly   670 PTAVKIQRTPPDP--PANNTL----AQLNQ------VGNVAKLRKNFVGSGLFRSKTPTADLYST 722
            ....|:|:...||  .|:|.|    ..|||      .....:|..|....|..||   ...|.|.
  Fly  2174 KITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRS---IVCLQSQ 2235

  Fly   723 QVKEVLPMRPKTPLVDTRRS----RV------QIQSPNNE------------------------V 753
              ::|...|.:.|::..||.    |:      :::.|.||                        :
  Fly  2236 --RDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFL 2298

  Fly   754 DDEGDG-----------AAAAERKPLQL---------QTQGKSNSSLQELDDIPYMDPYPKISRL 798
            |:||.|           ||..:|..|.:         .|:..:.|:......:.|.     ::|.
  Fly  2299 DEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYY-----VNRR 2358

  Fly   799 SERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTG 863
            ..             ||:       |.|||   ..|..|.:.....:..|.||......|....
  Fly  2359 EH-------------GIF-------PAPLP---QNSEICENVLKYFWFFGVFVAKVLQDMRLVD- 2399

  Fly   864 QYSPLQTAHLQ----NERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQC 924
              .||.|:.||    |:.:.|.:.:::|||                    |||.|..||||:|..
  Fly  2400 --IPLSTSFLQLLCHNKVLSRNLQKVISDR--------------------RNGDLSVVSEDSDIV 2442

  Fly   925 ELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHH 989
            |.....|...:                               .:.|....|||::.:..::.:.:
  Fly  2443 ETCTKLLRTDS-------------------------------NKSNAFGGILSLENLKEIDPTRY 2476

  Fly   990 KVVSLVGESALRGQV----TMILRRRRTPLLQQAPVSTQLRRYPYDVIVSRHENEGFGFVIISSS 1050
            :.:..:....||.|.    ..|...::..|:.:..:.||      :.:....|:....|..:.||
  Fly  2477 QFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQ------NGLEVSLEDLALTFTYLPSS 2535

  Fly  1051 NHYYGSTIGKLIP-GSPADRCGELKVGDRIVAVNRIEIAGMSHGD-VVNLIKESGLHVRLTI--- 1110
            : .||.|..:|:| ||..:           |.::.:|    ::.: ::|.|.:.|:..::..
  Fly  2536 S-IYGYTQAELLPNGSSVN-----------VTIDNLE----AYCELLMNFILQDGIAQQMKAFSD 2584

  Fly  1111 ----GVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQLSH 1147
                ..|||:           :::.||.:|...:...|..|
  Fly  2585 GFNEVFPLKK-----------LAAFTPSEARMMICGEQFPH 2614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	5/33 (15%)
		WW	342..372	CDD:238122	7/29 (24%)
		PDZ	443..534	CDD:214570	18/92 (20%)
		DegQ	<455..534	CDD:223343	16/80 (20%)
		PDZ_signaling	606..668	CDD:238492	17/66 (26%)
		PDZ	925..1011	CDD:214570	10/89 (11%)
		PDZ_signaling	1029..1110	CDD:238492	16/82 (20%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	83/465 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900