DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Magi and Hecw2

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_001001883.1 Gene:Hecw2 / 329152 MGIID:2685817 Length:1578 Species:Mus musculus


Alignment Length:1048 Identity:204/1048 - (19%)
Similarity:336/1048 - (32%) Gaps:340/1048 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 PLNASHQHQHSHPHPHPHPVAAATSFATF------NGNSNLNSSLANGSSRKFNCSRDNVDDGGD 123
            |.:.:.....::..|.|.....:|...:.      ...::..:|..:|.||:.....:::|.|.:
Mouse   542 PSSTAPDENEANLEPQPSADQGSTELCSSQEVDQPTSGADAGASDTSGGSRRAASETESLDQGSE 606

  Fly   124 AGEMAAASQTLSSAGTDVVGNGSGHGNGTVTGNGEKS-----------------GGLAPPGGHHL 171
            ..::::.::....|.|:.|...|....|.....|..|                 ..|     ...
Mouse   607 PSQVSSETEPSDPARTESVSEASTRPEGESDPEGADSSCNESVTTQLSSVETRCSSL-----ESA 666

  Fly   172 RPPPPPALKKSASAVIGNSASREDVASLSGTSSL----NSQMSVHNQFISGLPSNGIGSNGVHGG 232
            |.|..||.         :|...||.|..:..:|.    .||.||...  |.||:..:.|....|.
Mouse   667 RFPETPAF---------SSQEEEDGACAAEPTSSGPAEGSQESVCTP--SSLPAVQVPSREEEGS 720

  Fly   233 AATGRGGPPNSIL------KGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGL 291
            ||..........|      :||.|            |.::........|.|.|   ...|.||..
Mouse   721 AAEAAALSEQGELGEVWQRRGSLE------------GAAAAAPAAAATDSQPQ---EDGDAGDAQ 770

  Fly   292 GPLPPKWETAYTERGELYFIDHNTGTSHW-----------LDPRLSKYQKKSLEDCCEDELPYGW 345
            |..  :..||..|..        ||.|..           :...:|:||:      .::.||..|
Mouse   771 GAC--EGATAQEEGA--------TGGSQTNGHQPLRSLPSVRQDVSRYQR------VDEALPPNW 819

  Fly   346 EKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQE-QRSKTPTALSET 409
            |...||...::::|||||.|.::.|......:..::|...|||:|..::.|. :|:.|.....|.
Mouse   820 EARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEEN 884

  Fly   410 MPT-----EAAEAHEQEED-ESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAG 468
            ...     |.|:.|:...| .....||:..:|:         ..|||..|..:.|.|        
Mouse   885 TSAIDGAGEEADFHQASADFRRENVLPHSTSRS---------RLTLLLQSPPVKFLI-------- 932

  Fly   469 GDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTC-------VLGYTHH--------DMV--- 515
              ..||.   ||:.:.|:         ...::.|:||       |...|||        |:|   
Mouse   933 --SPEFF---TVLHSNPS---------AYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFL 983

  Fly   516 NIFQSILPGERAALEVCRGYPLPFDPN------DPNTEVVTTMAVDGRESDKQRRLNMDGNYNFL 574
            |:|.:      ..||:.||:.:..|..      |.|:.  ||..:|.|                 
Mouse   984 NMFAN------KQLELPRGWEMKHDHQGKAFFVDHNSR--TTTFIDPR----------------- 1023

  Fly   575 DLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEG 639
             |..:.::.||.     ::.::......|...|.:|     .||.  .....:|.|...|     
Mouse  1024 -LPLQSSRPTSA-----LVHRQHLTRQRSHSAGEVG-----EDSR--HAGPPVLPRPSST----- 1070

  Fly   640 DVLLEINGLNVRNKPHFY----------VVELLKECSQTTPTAVKI-QRTPPDPPANNTLAQLNQ 693
                    .|..::|.:.          :|..|::     |..::| |...||...|::|.:..|
Mouse  1071 --------FNTVSRPQYQDMVPVAYNDKIVAFLRQ-----PNILEILQERQPDLARNHSLREKIQ 1122

  Fly   694 VGNVAKLRKNFVGS----GLFR--SKTPTADLYSTQVKEVLPMRPKTPLV------DTRRSRVQI 746
                      |:.:    ||.|  |......|.|...:|::...|...|:      ..|.|  .:
Mouse  1123 ----------FIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGS--PV 1175

  Fly   747 QSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPY-----------------MDPYPK 794
            .||.|....:...|.|.  .|.:...:.|..:..::|:...|                 .|.:.:
Mouse  1176 SSPQNSPGTQRANARAP--APYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQ 1238

  Fly   795 ISRLSERLAE-----VTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQ 854
            |...|.:..:     ||..|:.  |:....||.:            :.:....:.:.| |:...:
Mouse  1239 IMGYSRKDLQRNKLYVTFVGEE--GLDYSGPSRE------------FFFLVSRELFNP-YYGLFE 1288

  Fly   855 QAAMSGTTGQYSPLQTAHLQNE----RIQRRVNEL--------------------------LSDR 889
            .:|....|.|.||: :|.:.|.    |...|:..|                          ||| 
Mouse  1289 YSANDTYTVQISPM-SAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSD- 1351

  Fly   890 RRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTV 954
                ...||  ::...|..|        .:|.|..::.::|.......||           |:|.
Mouse  1352 ----LEYLD--EEFHQSLQW--------MKDNDIHDILDLTFTVNEEVFG-----------QITE 1391

  Fly   955 GHIVPGGA 962
            ..:.||||
Mouse  1392 RELKPGGA 1399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 6/39 (15%)
WW 342..372 CDD:238122 12/29 (41%)
PDZ 443..534 CDD:214570 24/108 (22%)
DegQ <455..534 CDD:223343 20/96 (21%)
PDZ_signaling 606..668 CDD:238492 11/71 (15%)
PDZ 925..1011 CDD:214570 9/38 (24%)
PDZ_signaling 1029..1110 CDD:238492
Hecw2NP_001001883.1 HECW_N 45..164 CDD:374632
C2_NEDL1-like 185..320 CDD:176073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..453
DMP1 <344..700 CDD:369294 29/171 (17%)
NESP55 <463..639 CDD:115071 15/96 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..802 56/300 (19%)
Interaction with TP73. /evidence=ECO:0000250 737..1074 94/449 (21%)
WW 815..844 CDD:366073 12/28 (43%)
HECW1_helix 921..987 CDD:375862 20/87 (23%)
WW 993..1022 CDD:366073 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1075 11/69 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1193 7/29 (24%)
HECTc 1222..1576 CDD:238033 39/220 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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