DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Trip12

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_038939619.1	Gene:	Trip12 / 316575	RGDID:	1306607	Length:	2074	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	217/1212 - (17%)
Similarity:	365/1212 - (30%)	Gaps:	425/1212 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ATTTSTAGGGAGV-------AARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSNHF-------YQ 56
            |:.:||...||.|       .||...:|.||:     .::..::::|.:...|:.|       .:
  Rat   252 ASASSTVPAGARVKQGKDQNKARRSRSASSPS-----PRRSSREKEQSKTGGSSKFDWAARFSPK 311

  Fly    57 QQQPQQLAPLNASHQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDG 121
            ...|:....|..|.:.:.|.|.|                 |.|.:.||  |.||....|..
  Rat   312 VSLPKTKLSLPGSSKSETSKPGP-----------------SGLQAKLA--SLRKSTKKRSE---- 353

  Fly   122 GDAGEMAAASQ------TLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHL--------- 171
            ....|:.:..:      |.|.|.|...|:|.|..........||   :|.|.|:..
  Rat   354 SPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEK---MADPEGNQETVNSSAART 415

  Fly   172 -RPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNG------V 229
             ..|...|...|.:..:|.:.|.|..:..|....|.:.:...     |||.:..|..|      .
  Rat   416 DEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALLEAR-----GLPPHLFGPLGPRMSQLF 475

  Fly   230 HGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSS--------------LGSECGVGDVQHQN 280
            |....:|.......:|:|.            :..|.|              :|:|
  Rat   476 HRTIGSGASSKAQQLLQGL------------QASDESQQLQAVIEMCQLLVMGNE---------- 518

  Fly   281 HESHDDPGDGLGPLPPKWETAYTERGELYFIDHN--------TGTSHWLD--PR----------- 324
                    :.||..|.|  :.......|..::||        ...::.::  ||
  Rat   519 --------ETLGGFPVK--SVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPV 573

  Fly   325 -----------------------LSKYQKKSL----------------------------EDCCE 338
                                   ||:...|::                            .:||:
  Rat   574 FLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQ 638

  Fly   339 DELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAK----RRAAEQSQQQQQMQQQ------QQ 393
            ...|..:..:.||:..:     ..|.|..:...:|:.    .|..:..|.::.:.||      ..
  Rat   639 SITPDEFHFVADSLPLL-----TQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLT 698

  Fly   394 QMQEQRSKTPTALSETM---------------PTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQ 443
            .:|:....||..||..|               ||.|.:..:|           .|| :.||.
  Rat   699 NVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQ-----------SFT-DIAET--- 748

  Fly   444 RINTTLLKSSRGLGFTIVG-SDGSAGGDVEEFLQIKTVVPNGPAWL------------------- 488
                        |.|.:.| |:||....::       :||..|..|
  Rat   749 ------------LHFLLCGASNGSCQEQID-------LVPRSPQELYELTSLICELMPCLPKEGI 794

  Fly   489 ---DGQLQTGDVLVYVNDTCVLGYTH-----HDMVNIFQSILPGERAALEV----------CRGY 535
               |..|:.|:  ....|..:..:..     |....|...|:  |.||.:|          .|.|
  Rat   795 FAVDTMLKKGN--AQNTDGAIWQWRDDRGLWHPYNRIDSRII--EVAAHQVGEDEISLSTLGRVY 855

  Fly   536 PLPFDP-NDPNTEVVTTMAVDGRESDKQRRLNMDGNYN---FLDLSGEGAKKTSGSGSGFILMKK 596
            .:.|:. ...|.:..|..|:       ||:.|...|.|   :.||..:.|:..        |||:
  Rat   856 TIDFNSMQQINEDTGTARAI-------QRKPNPLANTNTSGYSDLKKDDARAQ--------LMKE 905

  Fly   597 PEIYTFSIMKGSMGFGFTIADSACG--------------------QIVKKILDRNC-----CTQL 636
            ......|.:|...|..:.:..|:.|                    :::|.:|..:.     .:.|
  Rat   906 DPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASML 970

  Fly   637 MEGDVLLEINGLN-----VRNKPHFY--------VVELLKECSQTTPTAVKIQRTPPDPPANNTL 688
            ...|:.:.:..|.     ::..|..:        |:..:|..:::.    .:..:||....|
  Rat   971 SSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESE----SLLTSPPKACTN--- 1028

  Fly   689 AQLNQVGNVAKLRKNFVGSGLFRSKTP------------TADLYSTQVK----EVLPMRPKTPLV 737
                             |||...|.||            :|||.|..::    :.|.:.|:..|.
  Rat  1029 -----------------GSGSLGSTTPASSGTATAATNASADLGSPSLQHSRDDSLDLSPQGRLS 1076

  Fly   738 DT-RRSRVQIQSPNN------EVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKI 795
            |. :|.|:..:.|..      ..||:.|..|   :.|  ..||...:|.|..|:        ||.
  Rat  1077 DVLKRKRLPKRGPRRPKYSPPRDDDKVDNQA---KSP--TTTQSPKSSFLASLN--------PKT 1128

  Fly   796 -SRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMS 859
             .|||.:.....::.....|:.|:..:.....:.....:.......||.::...||   ....|.
  Rat  1129 WGRLSAQSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYF---SSENMD 1190

  Fly   860 GTTGQYSPLQTAHLQNERIQRRVN---ELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDA 921
            |:....:.||......|::..:|:   |.|.:.|.:...:.....::|||...:...|...|:..
  Rat  1191 GSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSE 1255

  Fly   922 DQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAA 963
            ......|:.|:|....|....:.|.|     .||.:.|.|.|
  Rat  1256 KDAVSREIRLKRFLHVFFSSPLPGEE-----PVGRVEPVGHA 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	5/38 (13%)
		WW	342..372	CDD:238122	5/29 (17%)
		PDZ	443..534	CDD:214570	21/128 (16%)
		DegQ	<455..534	CDD:223343	21/116 (18%)
		PDZ_signaling	606..668	CDD:238492	12/99 (12%)
		PDZ	925..1011	CDD:214570	11/39 (28%)
		PDZ_signaling	1029..1110	CDD:238492
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396	35/261 (13%)
		WWE	814..876	CDD:397111	13/70 (19%)
		HECTc	1672..2072	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900