DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and Wwtr1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001020040.1	Gene:	Wwtr1 / 295062	RGDID:	1559609	Length:	395	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	87/419 - (20%)
Similarity:	141/419 - (33%)	Gaps:	126/419 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LAPPGG-----------------HHLRPPPPPALKKSASAVIGNSASRE-DVASLSGTSSLNSQM 209
            |.|||.                 :.:..|.|.:.:|.   ::..|..:| |..|.|..||.:|.
  Rat    10 LPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKK---ILPESFFKEPDSGSHSRQSSTDSS- 70

  Fly   210 SVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGV- 273
                                        ||.|...|.|..:::..::    ......||:..|.
  Rat    71 ----------------------------GGHPGPRLAGGAQHVRSHS----SPASLQLGTGAGAA 103

  Fly   274 -GDVQHQNH--ESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLE- 334
             |..|...|  :...|..|.| ||||.||..:|..|:.||::|....:.|.|||  |...:.|.
  Rat   104 GGPAQQHAHLRQQSYDVTDEL-PLPPGWEMTFTATGQRYFLNHIEKITTWQDPR--KVMNQPLNH 165

  Fly   335 -----DCCEDELPYGWEKIEDSMYGMYFIDHVNRRT----------QYENP---VLEAKRRAAEQ 381
                 ......:|.....:......|   :|.:::.          ..:||   ::........|
  Rat   166 VNLHPTITSTSVPQRSMAVSQPNLAM---NHQHQQVVATSLSPQNHPAQNPPTGLMSVPNALTTQ 227

  Fly   382 SQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHE---QEEDESPMKLP------YKFTRNP 437
            .||||:::.|:.||:.:|.:  ....|.|..|||...:   :.|..:|:..|      ...|.:.
  Rat   228 QQQQQKLRLQRIQMERERIR--MRQEELMRQEAALCRQLPMETETMAPVNTPAMNTDMRSVTNSS 290

  Fly   438 AE--LQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNG---------------- 484
            ::  |.|...::....:..|||....    |.....|:||.....:..|
  Rat   291 SDPFLNGGPYHSREQSTDSGLGLGCY----SVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTR 351

  Fly   485 -PAWLD---------GQLQTGDVLVYVND 503
             |.:||         |.|::.|::...||
  Rat   352 FPDFLDCLPGTNVDLGTLESEDLIPLFND 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	11/28 (39%)
		WW	342..372	CDD:238122	5/42 (12%)
		PDZ	443..534	CDD:214570	16/87 (18%)
		DegQ	<455..534	CDD:223343	16/75 (21%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Wwtr1	NP_001020040.1	WW	125..156	CDD:197736	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900