DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Mpdz

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	1385	Identity:	254/1385 - (18%)
Similarity:	436/1385 - (31%)	Gaps:	512/1385 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQLAPLNASHQHQHSHPHPHPHPVAAATSFATFNGN 96
            :|.|::...|...|:||..|       .|..::|                    ||||..|.:
  Rat   888 HLSLEELYTQNLLQRQHAGS-------PPTDMSP--------------------AATSGFTVS-- 923

  Fly    97 SNLNSSLANGSSRKFNCSR------DNVDDGGDAGEMA--------------------AASQTLS 135
               :.:.||...:|:.|:.      ..:..|....|:|                    |.|.||.
  Rat   924 ---DYTPANAVEQKYECANTVAWTPSQLPSGLSTTELAPALPAVAPKYLTEQSSLVSDAESVTLQ 985

  Fly   136 SAG------TDVVGNGSGHGNGTVTGNGEKSGGLAPP---GGHHLRPPPPPALKKSASAVIGN-- 189
            |..      |..:..||.....||:.|.:..|.:...   ||         |:.:.....:|:
  Rat   986 SMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGG---------AISRDGRIAVGDCI 1041

  Fly   190 -SASREDVASLSGTSSLNSQMSVHNQF-----ISGLPSN-----------------------GIG 225
             |.:.|...||:...: .:.:..|:..     .|..|::                       |..
  Rat  1042 LSINEESTISLTNAQA-RAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFGQQ 1105

  Fly   226 SNGVHG----GAATGRGGP--PNSILKGSKENLLQNTYYNGET--------------------GD 264
            :.|:..    .:.|||..|  |.......:|:.|||..|:..:                    |.
  Rat  1106 AGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGG 1170

  Fly   265 SSLGSECGVGDVQHQ---NHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLS 326
            ..:||....|:|...   .|...|.|....|.|.|         |:                |:.
  Rat  1171 RGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKP---------GD----------------RIV 1210

  Fly   327 KYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYE------------------NPVLE 373
            :.....|.|...::......|....:  ::.:..:..|.:..                  ||..|
  Rat  1211 EVDGMDLRDASHEQAVEAIRKAGSPV--VFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAE 1273

  Fly   374 AKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSE-----TMPTEAAEAHEQEEDESPMKLPYKF 433
            :.:..::::..|.:.:.::..:....|.:|:..||     ..|:....|.::::::   :..|.:
  Rat  1274 SLQLTSDKAPSQSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDEDKED---EFGYSW 1335

  Fly   434 TRNPAE----LQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQT 494
             :|..|    |.||.....|.|...|||.::.|:.......|    .|..:.|.|.|..||:||.
  Rat  1336 -KNIQERYGTLTGQLHMIELEKGHSGLGLSLAGNKDRTRMSV----FIVGIDPTGAAGRDGRLQI 1395

  Fly   495 GDVLVYVNDTCVLGYTHHDMVNIFQ--------------------SILPGERAALEVCRGYPLPF 539
            .|.|:.:|...:.|.:|.:..:|.:                    ::.||..|.       |||.
  Rat  1396 ADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGSAAD-------PLPS 1453

  Fly   540 DPNDP-NTEV---VTT------------------------------------------------M 552
            ....| |.||   :||                                                .
  Rat  1454 TSESPQNKEVEPSITTSASAVDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGA 1518

  Fly   553 AVDGRESDKQRRLNMDGNY-------NFLDL---------------------------SGEGAKK 583
            |.|||.....|.|.:|...       .|:.|                           :..|.:|
  Rat  1519 AKDGRLKPGDRILAVDDELVAGCPIEKFISLLKTAKTTVKLTVGAENPGCQAVPSAAVTASGERK 1583

  Fly   584 ------------------TSGSGSGFILMKKPEI--------YTFSIMKGSMGFGFTI---ADSA 619
                              ||.|.:..|....|..        .|..|.||..|.|.:|   :|:.
  Rat  1584 DSSQTPAVPAPDLEPIPSTSRSSTPAIFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTL 1648

  Fly   620 CGQ-IVKKILDRNCCT---QLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPP 680
            .|. |:.::.:.....   :|..||.:||:||:::|...|...:.:|::    ||..|::.
  Rat  1649 LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ----TPQRVRLT---- 1705

  Fly   681 DPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTP-----TADLYSTQVKEVLPMRPKTPLVDTR 740
                                        |:|.:.|     ..|.::.::::    ||...|
  Rat  1706 ----------------------------LYRDEAPYKEEDVCDTFTVELQK----RPGKGL---- 1734

  Fly   741 RSRVQIQSPNNEV-----DDEGDGAAAAERKPLQ----LQTQGKSNSSLQELDDIPYMDPYPKIS 796
              .:.|....|:.     |....|.|.|:.:.:|    |...|         :|:.........:
  Rat  1735 --GLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNG---------EDVRNATQEAVAA 1788

  Fly   797 RLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGT 861
            .|...|..|||:   .|.|...|          .|.|.           ||....|..::::|..
  Rat  1789 LLKCSLGTVTLE---VGRIKAAP----------FHSER-----------RPSQSSQVSESSLSSF 1829

  Fly   862 TGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCEL 926
            :...|.:.|:  ::.....:.|.|.|:.:  |...:    :::..|:           ||
  Rat  1830 SLPRSGIHTS--ESSESSAKKNALASEIQ--GLRTV----EIKKGPA-----------DA----- 1870

  Fly   927 TEVTLERQALGFGFRIVGGTEEGS-----QVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNS 986
                       .|..|.||.  ||     .:.:..:.|.|.|.|.|::..||.|::|.|.:....
  Rat  1871 -----------LGLSIAGGV--GSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTDGM 1922

  Fly   987 SHHKVVSLVGESA--------LRGQVTMILRRRR---TPLLQQAPVSTQLRRYPYDV-------I 1033
            :|.:.|:|:..::        ..|.|:::...::   .|.|....: |....:|.|:       |
  Rat  1923 THTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGL-TSSTIFPDDLGPPQSKTI 1986

  Fly  1034 VSRHENEGFGFVIISSSNHYYGSTIGKL--------IPGSPADRCGELKVGDRIVAVNRIEIAGM 1090
            ......:|.||.|:..    |||..|.|        ..|:.|:. |.||.||:|:|||...:.|:
  Rat  1987 TLDRGPDGLGFSIVGG----YGSPHGDLPIYVKTVFAKGAAAED-GRLKRGDQIIAVNGQSLEGV 2046

  Fly  1091 SHGDVVNLIKESGLHVRLTI 1110
            :|.:.|.::|.:...|.|.:
  Rat  2047 THEEAVAILKRTKGTVTLMV 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	3/28 (11%)
		WW	342..372	CDD:238122	4/47 (9%)
		PDZ	443..534	CDD:214570	25/110 (23%)
		DegQ	<455..534	CDD:223343	22/98 (22%)
		PDZ_signaling	606..668	CDD:238492	18/68 (26%)
		PDZ	925..1011	CDD:214570	21/98 (21%)
		PDZ_signaling	1029..1110	CDD:238492	29/95 (31%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	552..621	CDD:238492
		PDZ_signaling	693..776	CDD:238492
		PDZ_signaling	993..1063	CDD:238492	15/79 (19%)
		PDZ_signaling	1150..1241	CDD:238492	16/117 (14%)
		PDZ	1348..1433	CDD:214570	22/88 (25%)
		PDZ_signaling	1482..1561	CDD:238492	9/78 (12%)
		MPDZ_u10	1563..1624	CDD:293272	7/60 (12%)
		PDZ	1625..1709	CDD:214570	24/119 (20%)
		PDZ_signaling	1721..1801	CDD:238492	18/101 (18%)
		PDZ_signaling	1858..1943	CDD:238492	22/117 (19%)
		PDZ_signaling	1984..2067	CDD:238492	27/88 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910