DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	136/636 - (21%)
Similarity:	213/636 - (33%)	Gaps:	191/636 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QQQQQQQQQQQH----FNSNHFYQQQQ----PQQLAP--------LNASHQHQHSHPHPHPH-PV 84
            ::..:|:...:|    .:||....|.|    |..|.|        |..::...|::.....| |.
  Rat   426 EENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPS 490

  Fly    85 AAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDD--------GGDAGE----------MAAAS 131
            ....|..:.|....:|...|:   |:|...|...:|        ||:..|          ||..|
  Rat   491 LMDVSSESDNNIRQINQEAAH---RRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDS 552

  Fly   132 QTLS-----------SAGTDVVGNGSGHGNGTVTGNGEKSGGL--APPGGH-------------- 169
            .:|:           ::..::....|.....|...|||:...|  ..|...
  Rat   553 LSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQA 617

  Fly   170 HLRPPPPPALKKSASAVIGNSASREDVASLSGTSSL-------------------NSQMSVHNQF 215
            ||.||..|..:..:|.|.|...|...||.:..|..|                   |::.:...:.
  Rat   618 HLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 682

  Fly   216 ISGLPSNGIGSNGVHGGAATGRGG--------PPNSI----------LKGSKEN----LLQNTYY 258
            |..|..:|.      .|:||....        .|.|:          |:|:|::    .:::|..
  Rat   683 IMQLAEDGA------SGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLS 741

  Fly   259 NGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDP 323
            |.:   |...|.......||:..:|.         |||.||......|..:||||||.|:.|.||
  Rat   742 NPQ---SPQPSPYNSPKPQHKVTQSF---------LPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 794

  Fly   324 RLSKY-----QKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYEN------PVLEAKRR 377
            || |:     .|.||.......||.|||:........::|||.::....||      |:.::|
  Rat   795 RL-KFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPLYDSK-- 856

  Fly   378 AAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEED------ESPMKLPYKF--- 433
                          ..|.::.|.:.|......:|  .:...:|:.|      :.|..:|.:|
  Rat   857 --------------ITQWEDPRLQNPAITGPAVP--YSREFKQKYDYFRKKLKKPADIPNRFEMK 905

  Fly   434 --TRNPAELQGQRINTT----LLK--------SSRGLGFTIVGSDGSAGGDVEE-FLQIKTVVPN 483
              ..|..|...:||.:.    :||        |.:||.:         ||...| |..:...:.|
  Rat   906 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY---------GGVAREWFFLLSKEMFN 961

  Fly   484 GPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRG 534
            ....|.....|.:..:.:|...  |..:.|.::.|..|  |..|.|.|..|
  Rat   962 PYYGLFEYSATDNYTLQINPNS--GLCNEDHLSYFTFI--GRVAGLAVFHG 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	14/28 (50%)
		WW	342..372	CDD:238122	10/35 (29%)
		PDZ	443..534	CDD:214570	23/103 (22%)
		DegQ	<455..534	CDD:223343	18/79 (23%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471
		WW	463..489	CDD:395320	3/25 (12%)
		WW	653..682	CDD:395320	2/28 (7%)
		WW	766..796	CDD:238122	15/29 (52%)
		WW	815..865	CDD:197736	13/65 (20%)
		HECTc	926..1255	CDD:214523	22/96 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900