DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and MAGI3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	1088	Identity:	321/1088 - (29%)
Similarity:	454/1088 - (41%)	Gaps:	343/1088 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EKSGGLAPPG---GHHLRPPPPPALKKS------ASAVIGNSASREDVASLSGTSSLNSQMSVHN 213
            |:||.|...|   |:....|.|||....      ...:..|....|.....:.:.|...:|.
Human   172 EESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMD--- 233

  Fly   214 QFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQH 278
               |.||..   .......|..|.|...|........:.::......:|..|          :..
Human   234 ---SSLPEE---EEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSS----------MDF 282

  Fly   279 QNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPY 343
            :|:...|:.   |.|||..||.|||:.|.:|||||||.|:.||||||.| :.|:.|||.:.||||
Human   283 RNYMMRDET---LEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCK-KAKAPEDCEDGELPY 343

  Fly   344 GWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSE 408
            |||||||..||.|::||:|::||:||||.||||:            :|..|::...||
Human   344 GWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRK------------KQLGQVEIGSSK------- 389

  Fly   409 TMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEE 473
               .:..::|              |||:|::|:|..:..:|.||:.|.||||:|.|..     :|
Human   390 ---PDMEKSH--------------FTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRP-----DE 432

  Fly   474 FLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLP 538
            |||:|.|:.:|||..||::..|||:|.:|..||||:||.|:|.:||.:...:...|.:|||||||
Human   433 FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497

  Fly   539 FDPNDPNTEVV-TTMAVDGRESDKQRR-------------LNMDGNYNFLDLSGEGAKKTSGSGS 589
            .|..||..::| .|..::|:...|...             |..:|.... .|:|:|....|.:..
Human   498 DDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGH-TLTGDGLNGPSDASE 561

  Fly   590 GFILM-----KKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLN 649
            ..:.|     .:||:.|..::||..||||.||||..||.||.|||...|..|.:||::.||...|
Human   562 QRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626

  Fly   650 VRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKT 714
            |:|..|..|||:||:
Human   627 VQNLTHLQVVEVLKQ-------------------------------------------------- 641

  Fly   715 PTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNS- 778
                         .|:....||:..|                  |...:..|..:::|..|.|:
Human   642 -------------FPVGADVPLLILR------------------GGPPSPTKTAKMKTDKKENAG 675

  Fly   779 SLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQ 843
            ||:.::     :|.|                             ||:|.|
Human   676 SLEAIN-----EPIP-----------------------------QPMPFP--------------- 691

  Fly   844 RYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPS 908
                      .....||     ||    .|....:..:...|..|:         ||.
Human   692 ----------PSIIRSG-----SP----KLDPSEVYLKSKTLYEDK---------PPN------- 721

  Fly   909 WRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGD 973
                     ::|.|      |.|.:|..|||||::||......:.:|.|:|.|||::|.|:...|
Human   722 ---------TKDLD------VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAAD 771

  Fly   974 EILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR-----RTPL--LQQAPVSTQ-----LR 1026
            |::.||||.|...||.:|:.|:..:|..|.|.:.:||:     :.|.  ..||.:|||     |.
Human   772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLN 836

  Fly  1027 R----------YPYDVIVSRHENEGFGFVIISSSN--------HYYGSTIGKLIPGSPADRCGEL 1073
            |          .||||::.|.|||||||||::|.|        |    .||::|.||||||||:|
Human   837 RAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH----KIGRVIEGSPADRCGKL 897

  Fly  1074 KVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASP 1138
            ||||.|.|||...|..:||.::|.|||::|:.|.||:....:..||..|.:|.        :.||
Human   898 KVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSA--------RQSP 954

  Fly  1139 SLLKAQLSHQQQLPQQH--LQQAQLNHHHQHLEMPMSMPVPGHGSYLE 1184
            :|             ||  :.|:|.||            :||..|.||
Human   955 AL-------------QHRPMGQSQANH------------IPGDRSALE 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	18/28 (64%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ	443..534	CDD:214570	38/90 (42%)
		DegQ	<455..534	CDD:223343	35/78 (45%)
		PDZ_signaling	606..668	CDD:238492	32/61 (52%)
		PDZ	925..1011	CDD:214570	33/85 (39%)
		PDZ_signaling	1029..1110	CDD:238492	47/88 (53%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273		16/99 (16%)
		WW	294..326	CDD:197736	21/31 (68%)
		WW	342..372	CDD:238122	20/29 (69%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		37/86 (43%)
		PDZ	413..493	CDD:214570	38/84 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		6/28 (21%)
		PDZ	575..656	CDD:214570	38/161 (24%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		33/87 (38%)
		PDZ_signaling	726..807	CDD:238492	33/86 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		7/21 (33%)
		PDZ_signaling	849..935	CDD:238492	48/89 (54%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		46/90 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		16/69 (23%)
		PDZ_signaling	1022..1100	CDD:238492
		Red1	<1132..1461	CDD:311769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7680
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1288
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm40810
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860