Protein Alignment Magi and MAGI3

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: NP_001136254.1
• Gene: MAGI3 / 260425
• HGNCID: 29647
• Length: 1481
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 321/1088 - (29%)
• Similarity: 454/1088 - (41%)
• Gaps: 343/1088 - (31%)

  Fly   158 EKSGGLAPPG---GHHLRPPPPPALKKS------ASAVIGNSASREDVASLSGTSSLNSQMSVHN 213
            |:||.|...|   |:....|.|||....      ...:..|....|.....:.:.|...:|.
Human   172 EESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMD--- 233

  Fly   214 QFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQH 278
               |.||..   .......|..|.|...|........:.::......:|..|          :..
Human   234 ---SSLPEE---EEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSS----------MDF 282

  Fly   279 QNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPY 343
            :|:...|:.   |.|||..||.|||:.|.:|||||||.|:.||||||.| :.|:.|||.:.||||
Human   283 RNYMMRDET---LEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCK-KAKAPEDCEDGELPY 343

  Fly   344 GWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSE 408
            |||||||..||.|::||:|::||:||||.||||:            :|..|::...||
Human   344 GWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRK------------KQLGQVEIGSSK------- 389

  Fly   409 TMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEE 473
               .:..::|              |||:|::|:|..:..:|.||:.|.||||:|.|..     :|
Human   390 ---PDMEKSH--------------FTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRP-----DE 432

  Fly   474 FLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLP 538
            |||:|.|:.:|||..||::..|||:|.:|..||||:||.|:|.:||.:...:...|.:|||||||
Human   433 FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497

  Fly   539 FDPNDPNTEVV-TTMAVDGRESDKQRR-------------LNMDGNYNFLDLSGEGAKKTSGSGS 589
            .|..||..::| .|..::|:...|...             |..:|.... .|:|:|....|.:..
Human   498 DDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGH-TLTGDGLNGPSDASE 561

  Fly   590 GFILM-----KKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLN 649
            ..:.|     .:||:.|..::||..||||.||||..||.||.|||...|..|.:||::.||...|
Human   562 QRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626

  Fly   650 VRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKT 714
            |:|..|..|||:||:
Human   627 VQNLTHLQVVEVLKQ-------------------------------------------------- 641

  Fly   715 PTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNS- 778
                         .|:....||:..|                  |...:..|..:::|..|.|:
Human   642 -------------FPVGADVPLLILR------------------GGPPSPTKTAKMKTDKKENAG 675

  Fly   779 SLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQ 843
            ||:.::     :|.|                             ||:|.|
Human   676 SLEAIN-----EPIP-----------------------------QPMPFP--------------- 691

  Fly   844 RYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPS 908
                      .....||     ||    .|....:..:...|..|:         ||.
Human   692 ----------PSIIRSG-----SP----KLDPSEVYLKSKTLYEDK---------PPN------- 721

  Fly   909 WRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGD 973
                     ::|.|      |.|.:|..|||||::||......:.:|.|:|.|||::|.|:...|
Human   722 ---------TKDLD------VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAAD 771

  Fly   974 EILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR-----RTPL--LQQAPVSTQ-----LR 1026
            |::.||||.|...||.:|:.|:..:|..|.|.:.:||:     :.|.  ..||.:|||     |.
Human   772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLN 836

  Fly  1027 R----------YPYDVIVSRHENEGFGFVIISSSN--------HYYGSTIGKLIPGSPADRCGEL 1073
            |          .||||::.|.|||||||||::|.|        |    .||::|.||||||||:|
Human   837 RAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH----KIGRVIEGSPADRCGKL 897

  Fly  1074 KVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASP 1138
            ||||.|.|||...|..:||.::|.|||::|:.|.||:....:..||..|.:|.        :.||
Human   898 KVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSA--------RQSP 954

  Fly  1139 SLLKAQLSHQQQLPQQH--LQQAQLNHHHQHLEMPMSMPVPGHGSYLE 1184
            :|             ||  :.|:|.||            :||..|.||
Human   955 AL-------------QHRPMGQSQANH------------IPGDRSALE 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800	18/28 (64%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	37/88 (42%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	35/79 (44%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	32/83 (39%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	48/89 (54%)
MAGI3	NP_001136254.1	PDZ0_MAGI-1_3-like	14..104	CDD:467212
		Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		NK	123..>197	CDD:450170	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..273		16/99 (16%)
		WW	294..326	CDD:197736	21/31 (68%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ1_MAGI-1_3-like	408..492	CDD:467213	37/88 (42%)
		Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157	410..492		37/86 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..570		6/28 (21%)
		PDZ2_MAGI-1_3-like	574..655	CDD:467214	39/161 (24%)
		PDZ3_MAGI-1_3-like	724..808	CDD:467215	34/89 (38%)
		Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157	726..808		33/87 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..843		7/21 (33%)
		PDZ4_MAGI-1_3-like	849..935	CDD:467216	48/89 (54%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289	851..938		46/90 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..976		16/69 (23%)
		PDZ5_MAGI-1_3-like	1019..1101	CDD:467217
		PTZ00121	<1148..>1454	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1170..1481