DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and HECTD1

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:1289 Identity:222/1289 - (17%)
Similarity:363/1289 - (28%) Gaps:480/1289 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TATTTSTAG-----------------GGAGVAARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSN 52
            |:|.|:..|                 |.:...:.|:.:..|| |...:.:...::...|:..:|:
Human  1448 TSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSP-DVSSVSELTNKEAASQRPLSSS 1511

  Fly    53 HFYQQQQPQQL---APLNASHQHQHSHPHPHPHPVAAATSF-------ATFNGNSNLNSSLANGS 107
            ...:......|   ||:::|    .|.|:......::..||       |..|..:|:|.|.::..
Human  1512 ASNRLSVSSLLAAGAPMSSS----ASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSD 1572

  Fly   108 SRKFNCSRD----------------NVDDGGDAG--EMAAASQTLSS---AGTDVVGNGSGHGNG 151
            :......|:                |:...|...  .|:.:|.|.||   ..|.|:..|....|.
Human  1573 NNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNT 1637

  Fly   152 TVTG----NGEKSGG-------------------LAPPGGHHLRPPPP----------------- 176
            ..|.    :.|...|                   ||........|.|.                 
Human  1638 LTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYE 1702

  Fly   177 -------PALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAA 234
                   |:|::.|       .||.||              .|:...|.||....|:    |...
Human  1703 EVMILRRPSLQRRA-------GSRSDV--------------THHAVTSQLPQVPAGA----GSRP 1742

  Fly   235 TGRGGPPNSILKGSKENLLQNTYYNGETGDS---SLGSECGVGDVQHQNHESHDDPGDGLGPLPP 296
            .|.........||.:.....:.|.......:   :.....|..:||.........||.....|..
Human  1743 IGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLE 1807

  Fly   297 KWETAYTERGELYFIDHNTGTSHWLDPRLSK-------YQKKSLEDCC-----EDELPYGWEKIE 349
            :.|...:.|..|.......||:..::..|:.       |.:|.|:..|     .|:|...||...
Human  1808 EVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTY 1872

  Fly   350 DSMY---------------GMYFIDHVNRRTQY-------------------------------E 368
            ..||               |.:.|:||.   ||                               .
Human  1873 TIMYREMKDSDKEKENGKMGCWSIEHVE---QYLGTDELPKNDLITYLQKNADAAFLRHWKLTGT 1934

  Fly   369 NPVLEAKRRAAE-------------------------QSQQQQQMQQQQQQMQEQRSKTPTALSE 408
            |..:...|..::                         ||.....:.::|.|.:....:....:.:
Human  1935 NKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQNSCGVED 1999

  Fly   409 TMP------TEAAEAH----EQEEDESPMKLPYKFTRNPAELQGQRINTTLLK------------ 451
            .:.      ..|::.:    :::.||.|     :||..|.|...::|.|.:|:            
Human  2000 VLQLLRILYIVASDPYSRISQEDGDEQP-----QFTFPPDEFTSKKITTKILQQIEEPLALASGA 2059

  Fly   452 ------------------SSRGLGFTIVGSDGSAG-----------------------GDVEEF- 474
                              .:|.|.||......|..                       .|..|| 
Human  2060 LPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFR 2124

  Fly   475 ---LQIKTV-VPNGPA---WLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVC 532
               |:.:.| ||.|.:   |.:..:|                .|.|..::.:....||       
Human  2125 VGRLKHERVKVPRGESLMEWAENVMQ----------------IHADRKSVLEVEFLGE------- 2166

  Fly   533 RGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKP 597
            .|..|     .|..|....:|.:.:.:|....|..|   ||.|  .|......|.|     :|.|
Human  2167 EGTGL-----GPTLEFYALVAAEFQRTDLGAWLCDD---NFPD--DESRHVDLGGG-----LKPP 2216

  Fly   598 EIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELL 662
            ..|               ...:||......        ..:.|.|..|..|.     ||..:.|.
Human  2217 GYY---------------VQRSCGLFTAPF--------PQDSDELERITKLF-----HFLGIFLA 2253

  Fly   663 KECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKE- 726
            | |.|.....        |.|.:....:|..:|::   :.|.  |.|........||:.|:.:. 
Human  2254 K-CIQDNRLV--------DLPISKPFFKLMCMGDI---KSNM--SKLIYESRGDRDLHCTESQSE 2304

  Fly   727 -----------------------VL-PMRPKTP-------------LVDTRRSRVQIQSPNNEVD 754
                                   :| |.:||.|             ||:..|:|..     .|:.
Human  2305 ASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFL-----KEIK 2364

  Fly   755 DEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMP 819
            |     .|.:|:      |..||..|.|             ...:.:|.|:.|:..:..|    |
Human  2365 D-----LAIKRR------QILSNKGLSE-------------DEKNTKLQELVLKNPSGSG----P 2401

  Fly   820 P-SMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVN 883
            | |::.|.|......|...|...|...:|.  .:.:...|.... :|..|......:..||:::.
Human  2402 PLSIEDLGLNFQFCPSSRIYGFTAVDLKPS--GEDEMITMDNAE-EYVDLMFDFCMHTGIQKQME 2463

  Fly   884 ELLSDRRRVGFANLDPPQQM--------------QHSPSWRNGALLDVSEDADQCELTEVTLERQ 934
            ..     |.||..:.|.:::              ..||||....:::.:|       .::...|.
Human  2464 AF-----RDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTE-------PKLGYTRD 2516

  Fly   935 ALGF--GFRIVGGTEEGS-----QVTVG--HIVPGGAADQDQRINTGDEILSID 979
            :.||  ..|::.|.....     |.|.|  .:.|||.|:...|:....::.:.|
Human  2517 SPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATD 2570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 6/28 (21%)
WW 342..372 CDD:238122 11/75 (15%)
PDZ 443..534 CDD:214570 22/151 (15%)
DegQ <455..534 CDD:223343 18/109 (17%)
PDZ_signaling 606..668 CDD:238492 11/61 (18%)
PDZ 925..1011 CDD:214570 14/64 (22%)
PDZ_signaling 1029..1110 CDD:238492
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269
Ank_2 366..457 CDD:403870
ANK repeat 366..393 CDD:293786
ANK 1 395..424
ANK repeat 396..426 CDD:293786
ANK 2 426..455
ANK repeat 428..457 CDD:293786
ANK 3 459..491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513
ANK 4 579..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748
Sad1_UNC 1107..1240 CDD:400199
MIB_HERC2 1277..1335 CDD:399589
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 18/107 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 3/19 (16%)
BTHB 1892..1965 CDD:408209 8/75 (11%)
K-box 2029..2103 12/73 (16%)
HECTc 2131..2608 CDD:238033 108/568 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 1/20 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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