DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Magi3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	1104	Identity:	319/1104 - (28%)
Similarity:	452/1104 - (40%)	Gaps:	376/1104 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EKSGGLAPPG---GHHLRPPPPPA-----LKKSASAVI-----GNSASREDVASLSGTSSLNSQM 209
            |:||.|...|   |:....|.|||     .......|:     ...:.|:...|:|....::|.:
  Rat   174 EESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSL 238

  Fly   210 SVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGD-SSLGSECGV 273
            ....:.......||.||.                                 ||.: .|..|:|.:
  Rat   239 PEEEEDEDKEAVNGSGSM---------------------------------ETREMHSESSDCWM 270

  Fly   274 GDV--QHQNHESHDDPG-----DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKK 331
            ..|  .:|.:.|.|...     :.|.|||..||.|||:.|.:|||||||.|:.||||||.| :.|
  Rat   271 KTVPSYNQTNRSMDFRNYMMRDENLEPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCK-KAK 334

  Fly   332 SLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQ 396
            :.|||.:.|||||||||||..||.|::||:|::||:||||.||||:        :|:.|
  Rat   335 APEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRK--------KQIGQ------ 385

  Fly   397 EQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIV 461
                    |.:.:..|:...||              |||:|::|:|..:..:|.||:.|.||||:
  Rat   386 --------AETHSAKTDVERAH--------------FTRDPSQLKGVLVRASLKKSTMGFGFTII 428

  Fly   462 GSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGER 526
            |.|..     :||||:|.|:.:|||..||::..|||:|.:|..||||:||.|:|.:||.:...:.
  Rat   429 GGDRP-----DEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQY 488

  Fly   527 AALEVCRGYPLPFDPNDPNTEVV-TTMAVDGRESDKQRRLNMDGNYNF----LDLSGEGAKKTS- 585
            ..|.:||||.||.|..||..::| .|..::|:...|........::..    ||.:|:..|..|
  Rat   489 VNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGKLLSS 553

  Fly   586 -----------------GSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCC 633
                             .|||     .:||:.|..::||..||||.||||..||.||.|||...|
  Rat   554 DHLNGPSDSNEQRASLASSGS-----SQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWC 613

  Fly   634 TQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVA 698
            ..|.:||::.||...||:|..|..|||:||:
  Rat   614 QGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQ---------------------------------- 644

  Fly   699 KLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAA 763
                                         .|:....||:..|                  |...:
  Rat   645 -----------------------------FPVGADVPLLILR------------------GGPCS 662

  Fly   764 ERKPLQLQTQGKSNS-SLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPL 827
            ..|..:::|..|..| ||:.:::                                  |:.||:|.
  Rat   663 PTKTAKMKTDTKETSGSLETINE----------------------------------PTPQPMPF 693

  Fly   828 PLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRV 892
            |                         .....||     ||    .|....:..:...|..|:
  Rat   694 P-------------------------PSIIRSG-----SP----KLDPSEVYLKSKTLYEDK--- 721

  Fly   893 GFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHI 957
                  ||.                ::|.|      |.|.:|..|||||::||......:.:|.|
  Rat   722 ------PPN----------------TKDLD------VFLRKQESGFGFRVLGGDGPDQSIYIGAI 758

  Fly   958 VPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR----------- 1011
            :|.|||::|.|:...||::.||||.|...||.:|:.|:..:|..|.|.:.:||:
  Rat   759 IPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDE 823

  Fly  1012 --------RTPLLQQAPVSTQLRRYP---YDVIVSRHENEGFGFVIISSSN--------HYYGST 1057
                    .:|.|.:..:.|  |..|   ||||:.|.|||||||||::|.:        |    .
  Rat   824 SPQAFSQSGSPRLNRTELPT--RSAPQESYDVILQRKENEGFGFVILTSKSKPPPGVIPH----K 882

  Fly  1058 IGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPG 1122
            ||::|.||||||||.|||||.|.|||...|..:||.::|.|||::|:.|.||:....:..||..|
  Rat   883 IGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSG 947

  Fly  1123 GSSVGVSSNTPLQASPSLLKAQLSHQQQLPQQH--LQQAQLNHHHQHLEMPMSMPVPGHGSYLE 1184
            .:|.        :.||:|             ||  :.|||..|            :||..:.||
  Rat   948 TNSA--------RQSPAL-------------QHRPMGQAQATH------------IPGDRTALE 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	18/28 (64%)
		WW	342..372	CDD:238122	20/29 (69%)
		PDZ	443..534	CDD:214570	38/90 (42%)
		DegQ	<455..534	CDD:223343	35/78 (45%)
		PDZ_signaling	606..668	CDD:238492	32/61 (52%)
		PDZ	925..1011	CDD:214570	33/85 (39%)
		PDZ_signaling	1029..1110	CDD:238492	47/91 (52%)
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:418433	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		17/114 (15%)
		HUL4	<211..>373	CDD:227354	66/195 (34%)
		WW	299..329	CDD:238122	19/29 (66%)
		WW	345..375	CDD:238122	20/29 (69%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		37/86 (43%)
		PDZ	416..496	CDD:214570	38/84 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575		4/29 (14%)
		PDZ	578..659	CDD:214570	38/161 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700		11/93 (12%)
		PDZ	729..812	CDD:214570	34/88 (39%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		33/87 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847		4/30 (13%)
		PDZ_signaling	851..936	CDD:238492	47/88 (53%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		46/90 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		15/69 (22%)
		PDZ_signaling	1023..1101	CDD:238492
		PTZ00112	1115..>1405	CDD:240274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7500
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1268
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm44951
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830