DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and NEDD4L

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens


Alignment Length:632 Identity:139/632 - (21%)
Similarity:214/632 - (33%) Gaps:184/632 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 QQQQQQQQQQQH----FNSNHFYQQQQ----PQQLAP--------LNASHQHQHSHPHPHPH-PV 84
            ::...|:...:|    .:||....|.|    |..|.|        |..::...|::.....| |.
Human   187 EENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPS 251

  Fly    85 AAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDD-------GGDAGE-MAAASQTLSSAGTDV 141
            ....|..:.|....:|...|:   |:|...|...:|       |||..| ....|:.::.|| |.
Human   252 LMDVSSESDNNIRQINQEAAH---RRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAG-DS 312

  Fly   142 VGNG-----SGHGNGT--------------VT--GNGEKSGGL------------------APPG 167
            :|..     :..|:.|              :|  .|||:...|                  |..|
Human   313 LGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQG 377

  Fly   168 GHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSL-------------------NSQMSVHN 213
              ||.||..||.:..:|.|.|.......||.:..|..|                   |::.:...
Human   378 --HLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWT 440

  Fly   214 QFISGLPSNGIGSNGVHGGAATGRGG--------PPNSI----------LKGSKEN----LLQNT 256
            :.|..|..:|.      .|:||....        .|.|:          |:|:|::    .:::|
Human   441 RPIMQLAEDGA------SGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDT 499

  Fly   257 YYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWL 321
            ..|.:   |...|.......||:..:|.         |||.||......|..:||||||.|:.|.
Human   500 LSNPQ---SPQPSPYNSPKPQHKVTQSF---------LPPGWEMRIAPNGRPFFIDHNTKTTTWE 552

  Fly   322 DPRLSKY-----QKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQ 381
            |||| |:     .|.||.......||.|||:........::|||.::....||...|:       
Human   553 DPRL-KFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRES------- 609

  Fly   382 SQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHEQEED------ESPMKLPYKF-----TR 435
               ......:..|.::.|.:.|......:|  .:...:|:.|      :.|..:|.:|     ..
Human   610 ---VPSYDSKITQWEDPRLQNPAITGPAVP--YSREFKQKYDYFRKKLKKPADIPNRFEMKLHRN 669

  Fly   436 NPAELQGQRINTT----LLK--------SSRGLGFTIVGSDGSAGGDVEE-FLQIKTVVPNGPAW 487
            |..|...:||.:.    :||        |.:||.:         ||...| |..:...:.|....
Human   670 NIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY---------GGVAREWFFLLSKEMFNPYYG 725

  Fly   488 LDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRG 534
            |.....|.:..:.:|...  |..:.|.::.|..|  |..|.|.|..|
Human   726 LFEYSATDNYTLQINPNS--GLCNEDHLSYFTFI--GRVAGLAVFHG 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 14/28 (50%)
WW 342..372 CDD:238122 9/29 (31%)
PDZ 443..534 CDD:214570 23/103 (22%)
DegQ <455..534 CDD:223343 18/79 (23%)
PDZ_signaling 606..668 CDD:238492
PDZ 925..1011 CDD:214570
PDZ_signaling 1029..1110 CDD:238492
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999
WW 224..250 CDD:278809 3/25 (12%)
WW 413..442 CDD:278809 2/28 (7%)
WW 526..556 CDD:238122 15/29 (52%)
WW 575..625 CDD:197736 12/59 (20%)
HECTc 662..1016 CDD:238033 27/120 (23%)
HECTc 686..1015 CDD:214523 22/96 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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