DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Yap1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	516	Identity:	108/516 - (20%)
Similarity:	168/516 - (32%)	Gaps:	184/516 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 TVTGNGEKSGGLAPPGGH---HLR---------------------------------------PP 174
            :|:..|..:...|||.||   |:|                                       ||
Mouse    20 SVSPAGTPAAPPAPPAGHQVVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPP 84

  Fly   175 PPPALKKSASAVIGNSA--SREDVASLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGR 237
            .|.:..:.||...|.:.  :.:.|.:.|..:||.         :..:....:.::||..|.|...
Mouse    85 EPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQ---------LGAVSPGTLTASGVVSGPAAAP 140

  Fly   238 GGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAY 302
            .                                     .||....|.:.|.|  .|||..||.|.
Mouse   141 A-------------------------------------AQHLRQSSFEIPDD--VPLPAGWEMAK 166

  Fly   303 TERGELYFIDHNTGTSHWLDPRLSKYQK------------KSLEDCCEDELPYGWEKIEDSMYGM 355
            |..|:.||::||..|:.|.|||.:...:            ::|.:.....||.|||:.......:
Mouse   167 TSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPAPASPAVPQTLMNSASGPLPDGWEQAMTQDGEV 231

  Fly   356 YFIDHVNRRTQYENPVLEAK-RRAAEQ----------------------------SQQQQQMQQQ 391
            |:|:|.|:.|.:.:|.|:.: .:|..|                            |.||||:|.|
Mouse   232 YYINHKNKTTSWLDPRLDPRFGKAMNQRITQSAPVKQPPPLAPQSPQGGVLGGGSSNQQQQIQLQ 296

  Fly   392 QQQMQEQRSK----------TPTALSETMPTEAAEAHEQE---EDESPMKLPYKFTRNPAELQG- 442
            |.||:::|.:          .|.|:....|:.|.....||   ..:.|.......|.|.....|
Mouse   297 QLQMEKERLRLKQQELFRQVRPQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTPNAVSSPGM 361

  Fly   443 -QRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTV-VPNGP-AWLDG--QLQTGDVLVYVN 502
             |.:.|....||.  .|...|:..|.....:..|.:.:. :|..| .:|:.  ::.|||
Mouse   362 SQELRTMTTNSSD--PFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGD------ 418

  Fly   503 DTCVLGYTHHDMVNIFQSILPGERAALEVCRGYP-----LPFDPNDPNTEVVTTMAVDGRE 558
                         .|.||.||.:::.      :|     ||....|..|.....|.::|.|
Mouse   419 -------------TISQSTLPSQQSR------FPDYLEALPGTNVDLGTLEGDAMNIEGEE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	13/28 (46%)
		WW	342..372	CDD:238122	10/29 (34%)
		PDZ	443..534	CDD:214570	19/94 (20%)
		DegQ	<455..534	CDD:223343	15/82 (18%)
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	14/88 (16%)
		WW	159..188	CDD:238122	13/28 (46%)
		WW	217..246	CDD:366073	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810