DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Wwc1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_740749.1	Gene:	Wwc1 / 211652	MGIID:	2388637	Length:	1104	Species:	Mus musculus

Alignment Length:	941	Identity:	194/941 - (20%)
Similarity:	304/941 - (32%)	Gaps:	320/941 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKK-SLEDCCEDELPYGWEKIEDSMYGMY 356
            |||..||.|....|::|:|||...|:.|:||| .:|.|. :..||..||||.|||:..|...|.|
Mouse     7 PLPEGWEEARDFDGKVYYIDHRNRTTSWIDPR-DRYTKPLTFADCISDELPLGWEEAYDPQVGDY 70

  Fly   357 FIDHVNRRTQYENPVLEAKRRAAEQ-------SQQQQQMQQQQQQMQEQRSKTPTALSETMPTEA 414
            ||||..:.||.|:|.::.:|.....       :|:....|::..|:::||
Mouse    71 FIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR--------------- 120

  Fly   415 AEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKT 479
            .|..:||..:......:|.        |.:::            .:.||..|:..|
Mouse   121 LELAQQEYQQLHAVWEHKL--------GSQVS------------LVSGSSSSSKYD--------- 156

  Fly   480 VVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDP 544
                 |..|..::.|....|        .....:||::...:...|       ||:.
Mouse   157 -----PEILKAEIATAKSRV--------NKLKREMVHLQHELQFKE-------RGFQ-------- 193

  Fly   545 NTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKPE---IYTFSIMK 606
                 |...:|.|.||.|      |.|. ||.:....::|..........:|.:   |.:.:::|
Mouse   194 -----TLKKIDERMSDAQ------GGYK-LDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLK 246

  Fly   607 GSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPT 671
            .    ||.             .||...:.|......||.:...:..       :.|...|||
Mouse   247 D----GFR-------------TDRGSHSDLWSSSSSLESSSFPMPK-------QFLDVSSQT--- 284

  Fly   672 AVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVK---EVLPMRPK 733
                     |...:.:.:..||:....:||..:.     .:|...|:|.....|   |..|
Mouse   285 ---------DISGSFSTSSNNQLAEKVRLRLRYE-----EAKRRIANLKIQLAKLDSEAWP---- 331

  Fly   734 TPLVDTRRSR-------------VQIQSPNNEVDDEGDGAAAAER---KPLQL--QTQGKSNSSL 780
             .::|:.|.|             ::..||......|.:....|.|   |.||.  .||.|:.:..
Mouse   332 -GVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTER 395

  Fly   781 QELDDIPYMDPYPKISRLSERLAEVTLQ-GDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQR 844
            .:|:.        |.::|...|.|.|.| ...:..:..:..|||.|                :..
Mouse   396 LKLNS--------KRNQLVRELEEATRQVATLHSQLKSLSSSMQSL----------------SSG 436

  Fly   845 YRPGYFVQAQ----------QAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDP 899
            ..||....::          ..:.|.|...|.|.:  .|.:| :|.:| |||......||
Mouse   437 SSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFE--QLDSE-LQSKV-ELLFLEGATGF----- 492

  Fly   900 PQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAAD 964
                  .||   |.:..:.||       ||...::|           |.||::.....:.|
Mouse   493 ------RPS---GCITTIHED-------EVAKTQKA-----------EGGSRLQALRSLSG---- 526

  Fly   965 QDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPL-LQQAPVSTQL--- 1025
                  |...:.|:...:.|:|.......|:.:..|.|...:      .|| .:...:||.|
Mouse   527 ------TPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFL------APLEFEDTELSTTLCEL 579

  Fly  1026 --------RRYPYDVIVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELKVGDRIVAV 1082
                    .||       |.|..|           ..|..:|:  ..|.|..|| |||.....||
Mouse   580 NLGGSGTQERY-------RLEEPG-----------PEGKPLGQ--AASVAPGCG-LKVACVSAAV 623

  Fly  1083 NRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQA----------- 1136
            :...:||           :||::         :.....||.|......:...:|
Mouse   624 SDESVAG-----------DSGVY---------EASAQRPGTSEAAAFDSDESEAVGATRVQIALK 668

  Fly  1137 ------SPSLLKAQLSHQQQLPQQHLQQAQL 1161
                  ..::|..||||...|..|..|:..:
Mouse   669 YDEKNKQFAILIIQLSHLSALSLQQDQKVNI 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	15/29 (52%)
		PDZ	443..534	CDD:214570	11/90 (12%)
		DegQ	<455..534	CDD:223343	11/78 (14%)
		PDZ_signaling	606..668	CDD:238492	10/61 (16%)
		PDZ	925..1011	CDD:214570	14/85 (16%)
		PDZ_signaling	1029..1110	CDD:238492	18/80 (23%)
Wwc1	NP_740749.1	WW	9..39	CDD:238122	14/30 (47%)
		WW	55..84	CDD:278809	15/28 (54%)
		ALDH-SF	378..>420	CDD:299846	13/49 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..449		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..547		9/58 (16%)
		C2_Kibra	661..784	CDD:176062	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..949
		Interaction with histone H3. /evidence=ECO:0000250	836..1104
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988
		ADDV motif	1102..1104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900