DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and yap-1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	106/498 - (21%)
Similarity:	161/498 - (32%)	Gaps:	198/498 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QQQQQQQQQQQQHFNSNHF-----------------YQQQQPQQLAPLNASHQHQHSHPHPHPHP 83
            ::.|:..||.:..|:.:|:                 |::.|.|:..||.:|:.||..:|....|
Worm     8 KKHQENSQQDKNQFSVHHYLDPNQSIHALISCSEKKYEKNQNQKKNPLPSSYYHQKRNPGSSAH- 71

  Fly    84 VAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTLSSAGTDVVGNGSGH 148
                                                  ...|.:..:|:|..|...|:|.|
Worm    72 --------------------------------------SPYGSVDESSRTAVSPAMDMVSN---- 94

  Fly   149 GNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHN 213
                          .||   .|.|....|.|..|    :.|..|       |.|....|..:||:
Worm    95 --------------QAP---IHTRQVSAPNLHTS----VNNGQS-------SATVPHPSHHNVHH 131

  Fly   214 QF---ISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGD 275
            |.   :|.||.. ||.:.|           |:.:...|.|   .|..|   .|.|.:..:.|
Worm   132 QHSKSVSALPMT-IGYSPV-----------PSHVKSVSHE---ANYSY---AGLSEIPQQQG--- 175

  Fly   276 VQHQNHE---SHD-------DPGD-GLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQ 329
            :..||.|   |.|       .|.| ...|:|..||..|...|..||.|||:.|:.|.||||.:
Worm   176 MMQQNREKSLSLDPMRRPFMTPQDVEQLPMPQGWEMCYDSDGVRYFKDHNSKTTTWDDPRLKQ-- 238

  Fly   330 KKSLEDCCEDELPYG-WEKIEDSMY-GMYFIDHVNR----------------RTQYENPVLEAKR 376
                    :::..:| .|.|..:.| ..|...|.:|                :.||.:   :.:.
Worm   239 --------QEQTGFGLGENIGQNRYNNCYDNGHSSRSLPSIHQHQQMIPNHPQPQYSS---QQQM 292

  Fly   377 RAAEQSQQQQQM-----------------------------------------QQQQQQMQEQRS 400
            ...:|.|.::.|                                         |||||....|:.
Worm   293 DYIQQLQNERMMIQEKNAQLINSGLVDSPQPPYQAISPMSSTMMHSHDPNFMYQQQQQAQNSQQQ 357

  Fly   401 KTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQ 443
            :||..|.: :|.:  ..:.|..|:|.|::.|....:|.:||.|
Worm   358 QTPHTLHQ-IPNQ--YQNSQMNDDSAMEVDYSMVSHPQQLQHQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	9/47 (19%)
		PDZ	443..534	CDD:214570	1/1 (100%)
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
yap-1	NP_001369894.1	WW	206..236	CDD:238122	14/29 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900