DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and magi-1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001255577.1	Gene:	magi-1 / 178107	WormBaseID:	WBGene00010444	Length:	1054	Species:	Caenorhabditis elegans

Alignment Length:	992	Identity:	299/992 - (30%)
Similarity:	426/992 - (42%)	Gaps:	312/992 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 NSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDD----PGDGLGPLPPKWETAY 302
            |.:|...  :||:|..|.|....:....||          .:.||    ..:||  |||.|||||
Worm   220 NKLLDSG--DLLENGTYQGHLYGTPRPVEC----------YADDDMMLMGSEGL--LPPNWETAY 270

  Fly   303 TERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQY 367
            ||.|:.|||||||||:.|.|||               |||.|||:::|..||.:::||:||:|||
Worm   271 TENGDKYFIDHNTGTTTWDDPR---------------ELPPGWEQVDDQNYGTFYVDHINRKTQY 320

  Fly   368 ENPV----------LEAKRRAAEQSQQQQQ-----------MQQQQQQMQEQRSKTPTAL----- 406
            |.|.          ...|......|.....           ::............:||..
Worm   321 ERPYGFGGSSATIDQPVKYGTLPSSTNHNHNNIYSHYNSGTLKSSSSPRDSGFDSSPTRYRKFGD 385

  Fly   407 -SETMPTEAAEAHEQE---EDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSA 467
             .||..:.|...|..:   ...:|:     ||.:||.|.|:.|:|.::|.::|||||::|:|.|:
Worm   386 PPETATSSADYDHHSKMFSRSSNPL-----FTTDPARLGGELISTKIVKGAKGLGFTLIGNDSSS 445

  Fly   468 GGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVC 532
            .||  ||:|:|:|:..|||..:|.|::||:||.||...:||.|..:..::|.:|...|...::||
Worm   446 RGD--EFIQVKSVLSGGPAAANGVLRSGDILVRVNGRLLLGATQKEACDVFVAIPVNEAVDIQVC 508

  Fly   533 RGYPLPFDP-NDPNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKK 596
            |||.|..|| |...||.|...|                                         |.
Worm   509 RGYELFIDPANRIVTENVYAAA-----------------------------------------KS 532

  Fly   597 PEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHFYVVEL 661
            .:::...|.|||.||||||||:..||.:||||..:.|..|||||.::|::|.|||..||..:|::
Worm   533 RDLHEIDIFKGSEGFGFTIADNLNGQRIKKILFPSQCPNLMEGDTIVELDGRNVRPIPHTQLVDM 597

  Fly   662 LKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKL--RKNFVGSGLFRSKTPTADL-YSTQ 723
            |:|                           ..:|...||  ::   ||...||:||:|.. |.
Worm   598 LRE---------------------------RPIGYRGKLVVKR---GSPKTRSRTPSAAFRYG-- 630

  Fly   724 VKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPY 788
                   .|:|.::|                       :|...|::.:|..:..:|..|.|.
Worm   631 -------EPQTNMMD-----------------------SAAPLPVRSKTPAERQTSRTEEDQ--- 662

  Fly   789 MDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQA 853
                 .:....:|...||.:.:      ||..::                  .|.|.||
Worm   663 -----NVRNTLQRQPAVTSEWE------GMSSAI------------------PASRMRP------ 692

  Fly   854 QQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFA--NLDPPQQMQHSPSWRNGALLD 916
                 |.||                             :|||  |..|..|....||
Worm   693 -----SSTT-----------------------------LGFATPNYIPLSQYNQKPS-------- 715

  Fly   917 VSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGI 981
                    :|..|:|.|:.:|||||::||.|..:.::||.||.||||::|.|:..||||:.|||.
Worm   716 --------DLITVSLIRKPVGFGFRLLGGVESKTPLSVGQIVIGGAAEEDGRLQEGDEIVEIDGH 772

  Fly   982 NVLNSSHHKVVSLVGESALRGQVTMILRR-------RRTPLLQQAPVSTQLRRYPYDVIVSRHEN 1039
            ||..:||.:.|.|:..:|....|.:|:||       ||..|....|..:      |||::.|:||
Worm   773 NVEGASHSEAVVLLEAAAQNKHVKLIVRRPSRTDPARRGSLNSAGPSGS------YDVLLHRNEN 831

  Fly  1040 EGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGL 1104
            :|||||:: ||.|..|||:|::.|||||.|||.|.||||::|||.|:|..:||.|.::|||:|||
Worm   832 DGFGFVLM-SSQHKNGSTVGQIQPGSPAARCGRLSVGDRVIAVNGIDILSLSHPDTISLIKDSGL 895

  Fly  1105 HVRLTIGVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKAQLSHQQQLPQQHLQQAQLNHHHQHLE 1169
            .|||||..|...|...|                  ::.|.|.          :...:|.|:   |
Worm   896 SVRLTIAPPNTAGPVLP------------------MVSATLG----------RNFTMNGHY---E 929

  Fly  1170 MPMSMPVPGHGSYLERP 1186
            ....:|.|....|.:.|
Worm   930 SNYGLPPPPPSVYEKHP 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	21/28 (75%)
		WW	342..372	CDD:238122	16/39 (41%)
		PDZ	443..534	CDD:214570	37/90 (41%)
		DegQ	<455..534	CDD:223343	34/78 (44%)
		PDZ_signaling	606..668	CDD:238492	33/61 (54%)
		PDZ	925..1011	CDD:214570	40/92 (43%)
		PDZ_signaling	1029..1110	CDD:238492	48/80 (60%)
magi-1	NP_001255577.1	NK	180..>244	CDD:302627	7/25 (28%)
		WW	263..293	CDD:238122	23/44 (52%)
		WW	294..323	CDD:278809	16/28 (57%)
		PDZ	421..510	CDD:214570	37/90 (41%)
		PDZ_signaling	535..600	CDD:238492	33/64 (52%)
		PDZ_signaling	717..800	CDD:238492	38/82 (46%)
		PDZ_signaling	822..902	CDD:238492	49/80 (61%)
		PDZ_signaling	968..1049	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166850
Domainoid	1	1.000	101	1.000	Domainoid score	I4372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1104
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		oto18300
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	1	1.100	-	-	LDO	PTHR10316
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3056
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.020