DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Grip2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	960	Identity:	195/960 - (20%)
Similarity:	304/960 - (31%)	Gaps:	359/960 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 PAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYV 501
            |.|.:|..:...:.:....||.||     |.|.|.:...::..:.|.|.|.....|..||.:..|
  Rat    45 PEEFRGITMVELIKREGSTLGLTI-----SGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSV 104

  Fly   502 NDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLN 566
            |...:....|.:::.:.:::  |||..|||....|.|...|:|.
  Rat   105 NGIRLTRLRHDEIITLLKNV--GERVVLEVEYELPPPAPENNPR--------------------- 146

  Fly   567 MDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKK---IL 628
                                     |:.|..::   |:.|....|||.:...|...:.|.   :|
  Rat   147 -------------------------IISKTVDV---SLYKEGNSFGFVLRGGAHEDLHKSRPLVL 183

  Fly   629 ---------DRNCCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPA 684
                     ||.  ..|..||.||.|:|:.:....|...:..|::||......|:.....||..|
  Rat   184 TYVRPGGPADRE--GSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQVEYDVATPDTVA 246

  Fly   685 NNTLAQLNQVGNVAKLRKNFVG----SGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQ 745
            |   |....|..:||...:.:|    :|..|:|                     |.:...|.:
  Rat   247 N---ASGPLVVEIAKTPGSALGISLTTGSHRNK---------------------PAITIDRIK-- 285

  Fly   746 IQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGD 810
               |.:.||  ..||..|....|.:......:.||.|...:        ::.::|:   |.|:
  Rat   286 ---PASVVD--RSGALHAGDHILAIDGTSTEHCSLVEATKL--------LASVTEK---VRLE-- 332

  Fly   811 ANGGIYGMPPSMQPLPLP----------LAHHESCY--CYD-----CQAQRYRPGYFVQAQQAAM 858
                |...|.|.:||..|          |.|.:.|.  |:.     |:|..:.||  .|.|..::
  Rat   333 ----ILPAPQSRRPLKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPG--GQDQSRSV 391

  Fly   859 SGT--------------------TGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQM 903
            |.|                    .|..||..||..:.:|.:...:.|......||     |..|:
  Rat   392 SSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVG-----PGGQI 451

  Fly   904 QHSPSWRNGALLDVSEDADQCELTEVTLERQAL-GFGFRIVGG---TEE-GSQVTVGHIVPGGAA 963
            .|:                  |.|||.|....| |||.::.||   ||. .|...|..|.|...|
  Rat   452 VHT------------------ETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPA 498

  Fly   964 DQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMIL-------------------- 1008
            ::...:..||.:|:|:||...:.:..:...|:.::||..:|.:.:
  Rat   499 ERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLP 563

  Fly  1009 ---------------RRRRTPL------------------------------LQQAPV--STQLR 1026
                           |:|..||                              |...|:  :.|:.
  Rat   564 KRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEYAVQIL 628

  Fly  1027 RYPYDVIV--------SRHENEGFGFVIISSSNHYYGSTIGKLIPGSP----------------A 1067
            |...|::.        :..|.|..|.|..:.....||..:|..|.|:.                |
  Rat   629 RQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLA 693

  Fly  1068 DRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTI---------------------- 1110
            :|.|.:.|||||:|:|.:.:.|....:.::|::.:|..|.|.|
  Rat   694 ERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDV 758

  Fly  1111 -------------------------------GVPLKEGGPSPGGS---SVGVSSNTP-------L 1134
                                           |....|||....||   .|.|.|.||       |
  Rat   759 DEDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEWRSSRL 823

  Fly  1135 QASPSLLKAQLSH------QQQLPQQHLQQAQLNHHHQHLEMPMSMPVPG 1178
            ::||..|:.:.:.      .:..|::         .....|.||| |.||
  Rat   824 KSSPPPLEPRRTSYTPGPTDESFPEE---------EEGDWEPPMS-PAPG 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570	22/90 (24%)
		DegQ	<455..534	CDD:223343	22/78 (28%)
		PDZ_signaling	606..668	CDD:238492	20/73 (27%)
		PDZ	925..1011	CDD:214570	29/125 (23%)
		PDZ_signaling	1029..1110	CDD:238492	25/104 (24%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492	21/88 (24%)
		PDZ_signaling	153..236	CDD:238492	21/87 (24%)
		PDZ_signaling	251..334	CDD:238492	22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		18/85 (21%)
		PDZ_signaling	456..544	CDD:238492	27/87 (31%)
		PDZ_signaling	557..640	CDD:238492	9/82 (11%)
		PDZ_signaling	657..737	CDD:238492	20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		0/23 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		21/86 (24%)
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910