DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and Trip12

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_011236956.1	Gene:	Trip12 / 14897	MGIID:	1309481	Length:	2074	Species:	Mus musculus

Alignment Length:	1129	Identity:	209/1129 - (18%)
Similarity:	343/1129 - (30%)	Gaps:	377/1129 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TATTTSTAGGGAGVAARGVATAKSPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQLAPLNAS 69
            |.:..||:..|:|:..||.|.|:.       |::....:..|:..||:.....:.||..|..::
Mouse   371 TGSCASTSRRGSGLGKRGAAEARR-------QEKMADPESNQETVNSSAARTDEAPQGAAASSS- 427

  Fly    70 HQHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTL 134
                          ||.|....|            :|.|.            .|..||......|
Mouse   428 --------------VAGAVGMTT------------SGESE------------SDDSEMGRLQALL 454

  Fly   135 SSAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSASREDVASL 199
            .:.|                         .||   ||..|..|.:.:.....||:.||.:....|
Mouse   455 EARG-------------------------LPP---HLFGPLGPRMSQLFHRTIGSGASSKAQQLL 491

  Fly   200 SG--TSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQN------- 255
            .|  .|..:.|:....:....|         |.|...|..|.|..|::. :...|||.
Mouse   492 QGLQASDESQQLQAVIEMCQLL---------VMGNEETLGGFPVKSVVP-ALITLLQMEHNFDIM 546

  Fly   256 -------TYYNGETGDSSLGSECGVG------------DVQHQNHESHDDPGDGLGPLPPKWETA 301
                   ||.......||......:.            ||..|...:       |..|..:...|
Mouse   547 NHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTA-------LEMLSRRHSKA 604

  Fly   302 YTERG-------ELYFIDHNTGTSHWLDPRLSKYQKKSL---EDCCEDELPYGWEKIEDSMYGMY 356
            ..:.|       .|.|...|.             |:.:|   .:||:...|..:..:.||:..:
Mouse   605 ILQAGGLADCLLYLEFFSINA-------------QRNALAIAANCCQSITPDEFHFVADSLPLL- 655

  Fly   357 FIDHVNRRTQYENPVLEAK----RRAAEQSQQQQQMQQQ------QQQMQEQRSKTPTALSETM- 410
                ..|.|..:...:|:.    .|..:..|.::.:.||      ...:|:....||..||..|
Mouse   656 ----TQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMF 716

  Fly   411 --------------PTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIV 461
                          ||.|.:..:|           .|| :.||.               |.|.:.
Mouse   717 IMVVRMFSLMCSNCPTLAVQLMKQ-----------SFT-DIAET---------------LHFLLC 754

  Fly   462 G-SDGSAGGDVEEFLQIKTVVPNGPAWL----------------------DGQLQTGDVLVYVND 503
            | |:||....::       :||..|..|                      |..|:.|:  ....|
Mouse   755 GASNGSCQEQID-------LVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGN--AQNTD 810

  Fly   504 TCVLGYTH-----HDMVNIFQSILPGERAALEV----------CRGYPLPFDP-NDPNTEVVTTM 552
            ..:..:..     |....|...|:  |.||.:|          .|.|.:.|:. ...|.:..|..
Mouse   811 GAIWQWRDDRGLWHPYNRIDSRII--EVAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTAR 873

  Fly   553 AVDGRESDKQRRLNMDGNYN---FLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFT 614
            |:       ||:.|...|.|   :.:|..:.|:..        |||:......|.:|...|..:.
Mouse   874 AI-------QRKPNPLANSNTSGYSELKKDDARAQ--------LMKEDPELAKSFIKTLFGVLYE 923

  Fly   615 IADSACG--------------------QIVKKILDRNC-----CTQLMEGDVLLEINGLN----- 649
            :..|:.|                    :::|.:|..:.     .:.|...|:.:.:..|.
Mouse   924 VYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEIL 988

  Fly   650 VRNKPHFY--------VVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVG 706
            ::..|..:        |:..:|..:::.    .:..:||....|                    |
Mouse   989 MQKLPDIFSVYFRREGVMHQVKHLAESE----SLLTSPPKACTN--------------------G 1029

  Fly   707 SGLFRSKTP------------TADLYSTQVK----EVLPMRPKTPLVDT-RRSRVQIQSPNN--- 751
            ||...|.||            :|||.|..::    :.|.:.|:..|.|. :|.|:..:.|..
Mouse  1030 SGSLGSTTPASSGTATAATNASADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKY 1094

  Fly   752 ---EVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKI-SRLSERLAEVTLQGDAN 812
               ..||:.|..|   :.|  ..||...:|.|..|:        ||. .|||.:.....::....
Mouse  1095 SPPRDDDKVDNQA---KSP--TTTQSPKSSFLASLN--------PKTWGRLSAQSNSNNIEPART 1146

  Fly   813 GGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNER 877
            .|:.|:..:.....:.....:.......||.::...||   ....|.|:....:.||......|:
Mouse  1147 AGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYF---SSENMDGSNPALNVLQRLCAATEQ 1208

  Fly   878 IQRRVN---ELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFG 939
            :..:|:   |.|.:.|.:...:.....::|||...:...|...|::.......|:.|:|....|.
Mouse  1209 LNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKNEKDAVGREIRLKRFLHVFF 1273

  Fly   940 FRIVGGTEEGSQVTVGHIVPGGAA 963
            ...:.|.|     .||.:.|.|.|
Mouse  1274 SSPLPGEE-----PVGRVEPVGHA 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	6/35 (17%)
		WW	342..372	CDD:238122	5/29 (17%)
		PDZ	443..534	CDD:214570	21/128 (16%)
		DegQ	<455..534	CDD:223343	21/116 (18%)
		PDZ_signaling	606..668	CDD:238492	12/99 (12%)
		PDZ	925..1011	CDD:214570	11/39 (28%)
		PDZ_signaling	1029..1110	CDD:238492
Trip12	XP_011236956.1	SRP1	489..>714	CDD:227396	47/259 (18%)
		WWE	814..876	CDD:397111	13/70 (19%)
		HECTc	1672..2072	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900