DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	1024	Identity:	199/1024 - (19%)
Similarity:	312/1024 - (30%)	Gaps:	363/1024 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 GLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYG 354
            |...||..|.......|.::||:.....:.||.||..  :..:.......:||.|||:.......
Human     7 GRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGFTEEGA 69

  Fly   355 MYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTAL-SETMPTEAAEAH 418
            .|||||..:.|.:.:||  ..:.:.|.|:...|.:......::.|::.|::: |||  :.|..|.
Human    70 SYFIDHNQQTTAFRHPV--TGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSET--STAGTAS 130

  Fly   419 EQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPN 483
            ..|....|                     .::|||     :.|.|.|.....:.....:..||
Human   131 TLEAKPGP---------------------KIIKSS-----SKVHSFGKRDQAIRRNPNVPVVV-- 167

  Fly   484 GPAWLDGQLQTGDVL-----VYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPND 543
             ..||..|..:|..|     ..:.|.|:..|.......:..||              |||
Human   168 -RGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSI--------------PLP----- 212

  Fly   544 PNTEVVTTMAVDGRESDKQRRLNMDGNYNFLDL-SGEGA----KKTSGS---GSGFILMKKPEIY 600
              :.|::.:|.:.|.|.|         |:|..: :|..|    ..|:||   .||.      ..|
Human   213 --SYVISPVAPEDRISRK---------YSFKAVHTGMRALIYNSSTAGSQAEQSGM------RTY 260

  Fly   601 TFSIMKGSMGFGFTIADS---------ACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNKPHF 656
            .||            ||:         |..| ..::|.|:...:.||
Human   261 YFS------------ADTQEDMNAWVRAMNQ-AAQVLSRSSLKRDME------------------ 294

  Fly   657 YVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTA--DL 719
                             |::|... |.||:| ...::.|.        ||.|..|......  |:
Human   295 -----------------KVERQAV-PQANHT-ESCHECGR--------VGPGHTRDCPHRGHDDI 332

  Fly   720 --YSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEG------DGAAAAERKPLQLQTQGKS 776
              :..|.:|....|.:...::.:|.|.:.:||.:..:::.      .|....:.:|.:.:..|..
Human   333 VNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGML 397

  Fly   777 NSSL---QELDDIPYMDPYP------KISRLSERLAEV------------------TLQGDANGG 814
            .:|.   ::.....|...:|      |.|:....||:|                  ||.....|.
Human   398 PASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQ 462

  Fly   815 IYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQ 879
            ....|.:.|.||....|...   ......|..|..:..||..|             :||:....:
Human   463 SLSFPENYQTLPKSTRHPSG---GSSPPPRNLPSDYKYAQDRA-------------SHLKMSSEE 511

  Fly   880 RRVN------ELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSEDADQC----ELTEVTLERQ 934
            ||.:      :|...::|         ||.:|.           |..|..|    |.|:....|.
Human   512 RRAHRDGTVWQLYEWQQR---------QQFRHG-----------SPTAPICLGSPEFTDQGRSRS 556

  Fly   935 ALGFGFRIVGGTEEGSQVTV----GHIVPGG------------------AADQDQR----INTGD 973
            .|          |....::|    ..|.|.|                  ....|||    |:.||
Human   557 ML----------EVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGD 611

  Fly   974 EILSIDGINVLNSSH-------------HKV--VSLVGESALRGQVTMILRRRRTPLLQQAPVST 1023
            ......|..|.||||             |.|  .||.|:|.  .:::::|              |
Human   612 SPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSL--EELSLLL--------------T 660

  Fly  1024 QLRRYPYDVIVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPAD----------RCGELKVGDR 1078
            :|||:...:...|:      |.|.....|..      ..|...||          ...:||:.:.
Human   661 RLRRHQAKLASVRN------FAISQLLQHQL------TFPTCQADDTYLQLKKDLEYLDLKIKNN 713

  Fly  1079 IVAVNRI------------EIAGMSHGDVVN-------LIKESGLHVRLTIGVPLKEGGPSPGGS 1124
            ...:|.:            ....|:..|::.       .|.||...|:|
Human   714 EPLINVLYKVLKKSARGCRPRRSMTGRDLLKDRSLKPVKIAESDTDVKL---------------- 762

  Fly  1125 SVGVSSNTPLQASPSLLKAQLSHQQQLPQ----QHLQQAQLNHHHQHLE 1169
            |:....:..||.....::|...::.||..    .|.|..|.....||||
Human   763 SIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLE 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	8/28 (29%)
		WW	342..372	CDD:238122	11/29 (38%)
		PDZ	443..534	CDD:214570	18/95 (19%)
		DegQ	<455..534	CDD:223343	15/83 (18%)
		PDZ_signaling	606..668	CDD:238492	8/70 (11%)
		PDZ	925..1011	CDD:214570	28/126 (22%)
		PDZ_signaling	1029..1110	CDD:238492	17/109 (16%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827	8/28 (29%)
		WW	56..85	CDD:306827	11/28 (39%)
		PH_PEPP1_2_3	159..281	CDD:270068	36/173 (21%)
		NESP55	<299..460	CDD:115071	30/170 (18%)
		DUF1640	779..905	CDD:311647	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900