DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and HECTD2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	175	Identity:	34/175 - (19%)
Similarity:	64/175 - (36%)	Gaps:	41/175 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PIITATTTSTAGGGAGVAARG-VATAKSPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQP----- 60
            ||::|...:|||...|  |:| ::|..|....:..:::..:.:....|....:....::|
Human    36 PIVSAGAGATAGLDRG--AKGQISTFSSFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICL 98

  Fly    61 ----QQLAPLNASHQHQHSHPHPHP-HPVAAAT-----------------------SFATFNGNS 97
                :|...::||.....:...|.| .|:...|                       ...||:...
Human    99 DVRQKQRTSMDASSSEMKAPVLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFP 163

  Fly    98 NLNSSLANGSSRKFNCSRDNVDDGG-DAGEMAAASQTLSSAGTDV 141
            .||::....::..||    .::|.| :|..:.|...||.:...||
Human   164 ELNAAFKKDATASFN----TIEDSGINAKFVNAVYDTLLNTPQDV 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809
		WW	342..372	CDD:238122
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		3/9 (33%)
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900