Protein Alignment Magi and kibra

DIOPT Version :10

• Sequence 1: NP_611551.1
• Gene: Magi / 37403
• FlyBaseID: FBgn0034590
• Length: 1202
• Species: Drosophila melanogaster
• Sequence 2: XP_061510240.1
• Gene: kibra / 1272272
• VectorBaseID: AGAMI1_015007
• Length: 1268
• Species: Anopheles gambiae
• Alignment Length: 951
• Identity: 181/951 - (19%)
• Similarity: 331/951 - (34%)
• Gaps: 212/951 - (22%)

  Fly   294 LPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFI 358
            ||..||......|::|||||....:.|:|||....:.::..||..:|||:|||:..|...|.|:|
Mosquito    10 LPLGWEINTDYDGKVYFIDHINKKTTWIDPRDKHTKPETFADCIGNELPFGWEESYDPQIGTYYI 74

  Fly   359 DHVNRRTQYENPVLEAKRRAAEQSQQ-----QQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAH 418
            :|..:.||.|:|.|:.|.:..|..::     |..::.:::.:..:..:...|..|.....|..|.
Mosquito    75 NHNTQTTQLEDPRLQWKSKQDEMLREYLCSAQDTLEAKKEILSVKTQRLHLAQEEYNHLNALAAS 139

  Fly   419 EQEEDESPMKLPYKFTRNPAELQGQ---------RINTTLLKSSRGLGFTIVGSDGSAGGDVEEF 474
            ......|......||  :|..|:..         |:...|.:..:.:..|..|.|..|  .||:.
Mosquito   140 RTSLCSSTSSCSTKF--DPELLRADLAIAKERVFRLKKELSRIQKEMHSTQKGVDTLA--SVEQK 200

  Fly   475 LQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYP--- 536
            |.         |.::|.....:....:          .::..|.:|::.|||...|:.:...
Mosquito   201 LN---------AHVNGCYNISEAQAIM----------EEVKKIQKSLITGEREKKELMKSLAQVK 246

  Fly   537 -----LPFDPNDPNTEVVTTMAVD------------------GRESDKQRRLNMDGNYNFLDLSG 578
                 |......|:.... .:|.|                  .||..|.|:...:......::..
Mosquito   247 DDLTRLQLRQESPDASTF-NLAQDRICAASQTDLSSEHFPMGAREMAKMRQRYDEWRRRVKEIQE 310

  Fly   579 EGAKKTSGSGSGFILMKKPEIYTFSIMKG-SMGFGFTIADSACGQIVKKILDRNCCTQLMEG-DV 641
            :.|........|.:...:..:..|...|. .:.:......|.....:::|  ::.|.||.|. ::
Mosquito   311 QLAALEEKIRPGELESDQDRLLLFQEKKQLLLEYRSITPKSRSPTEMRRI--QSVCRQLEEDLNM 373

  Fly   642 LLEINGLNVRNKPHFY---------VVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNV 697
            ..|.:...:.|:...:         ::|.|||.:........:..:.....::::|..|:...:.
Mosquito   374 AYEESNQCIANRLKLHEEKQALLQQLLEALKEFTHLEHQLKSLSASTLSISSSSSLGSLSTASSK 438

  Fly   698 AKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAA 762
            ..|      |||     ...|:|.    :.|...|:..:||..|...::..|::||      .:.
Mosquito   439 GSL------SGL-----SFTDIYG----DPLSAEPQIDMVDMNRRVQRLFHPSSEV------TSL 482

  Fly   763 AERKPLQLQTQGKSNSSLQEL------------DDIPYMDPYPKISRLSERLAEVTLQGDANGGI 815
            :.|..|..:|...|...:..:            .|.|..:|....:.::   ....|...|:|..
Mosquito   483 SPRSSLSTETPPVSPMKMDWVAVVTAAAAVAGGSDSPSANPASVHAAIN---TTAKLASAASGPS 544

  Fly   816 YGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQ---AQQAAMSGTTGQYSPLQTAHLQNER 877
            |..|.:.||:.                    |.|.|.   |..|:.:.|:.:|      :|..:|
Mosquito   545 YATPGTSQPVV--------------------PSYAVATGVASSASSTTTSTEY------NLDRQR 583

  Fly   878 IQRRVNELLSDRRRVGFANLDPPQQMQHSPSW-RNGALLDVSEDADQCELTEVTLERQALGFGFR 941
            ::.::.||  ..|::|.|. .|...:...||: ...|||..|...........|:..::
Mosquito   584 LEEQLQEL--KIRQLGIAG-GPLSPIYEKPSYLEPAALLSRSSSTSNTRSVSTTVSDES------ 639

  Fly   942 IVG--GTEEGSQVTVGHIVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESA----- 999
            :.|  |..|.|:..     |...|.:..::..|...::.||:..:..........:|..|
Mosquito   640 VAGDSGVFEASRGP-----PPLLARECAQVQIGLRYVAADGVLCITIERGSNFGALGPPAGCQLF 699

  Fly  1000 LRGQVTMILRRRRTPLLQQAPVSTQLRRYPYDVIVSRHENEGFGFVIISSSNHYYGSTIG---KL 1061
            :|   .|:|.....|.|.:....|.|.|..:..::          |:..|.:..|..::.   .:
Mosquito   700 IR---AMLLPTPSGPGLVRTGTVTDLVRPTFKTML----------VVPLSLDKVYAKSLHVKVMV 751

  Fly  1062 IPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVV-----NLIKESGLHVRLTIGVPLKEGGPSP 1121
            :.|...|..|.          .:|.:|..:.||..     |::....::..     .|.:||...
Mosquito   752 LVGQREDWIGS----------TQISLAEFNAGDATTSRWYNIVSRKSMNES-----DLLDGGARE 801

  Fly  1122 GGS--SVGVSSNT----------PLQASPSLLKAQLSHQQQ 1150
            ..|  |..:||.|          .|||...|:..:||:..:
Mosquito   802 ESSDESTIISSQTSTLTRNQGQDELQAVLELVYDELSNDDE 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_611551.1	WW	294..323	CDD:459800	11/28 (39%)
		WW	342..372	CDD:238122	13/29 (45%)
		PDZ1_MAGI-1_3-like	444..533	CDD:467213	17/88 (19%)
		PDZ2_MAGI-1_3-like	597..677	CDD:467214	14/90 (16%)
		PDZ3_MAGI-1_3-like	926..1010	CDD:467215	15/90 (17%)
		PDZ4_MAGI-1_3-like	1029..1111	CDD:467216	11/89 (12%)
kibra	XP_061510240.1	None