DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and WWP2

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens

Alignment Length:	803	Identity:	151/803 - (18%)
Similarity:	245/803 - (30%)	Gaps:	244/803 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NLNSSLANGSSR------KFNCSRDNVDDGGDAGEMAAASQTLSSAGTDV----VGNGSGHGNGT 152
            ||::.|.|...:      ..|...:|.......||:     |:...|..|    |.|||...:|:
Human   102 NLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGEL-----TIFLDGPTVDLGNVPNGSALTDGS 161

  Fly   153 VTGNGEKSGGLAPPGGHHLRPPPPPALKKSASAVIGNSAS-REDVASLSGTSSLNSQ----MSVH 212
            ...:.:.||....|...| :||       |.:...|.|.: |...||...|.:...|    .|.|
Human   162 QLPSRDSSGTAVAPENRH-QPP-------STNCFGGRSRTHRHSGASARTTPATGEQSPGARSRH 218

  Fly   213 NQFISGLPSNGIGSNGVHGGAAT----------GRGGPPNSILKGSKENLLQNTYYNGETGDSSL 267
            .|.:.....:|:.:..|:....|          |...||.:.|..:..   .||.........:.
Human   219 RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPN---PNTTSLPAPATPAE 280

  Fly   268 GSECGVGDVQHQNHESHDDPGDGLGP--LPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQK 330
            |.|......|..       |.....|  ||..||......|.:|::||||.|:.|
Human   281 GEEPSTSGTQQL-------PAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTW---------- 328

  Fly   331 KSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQM 395
                   |..||.||||..|.....|::||..|.|.::.|..|..|...:...|:.|:|...|.
Human   329 -------ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQH- 385

  Fly   396 QEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTI 460
                      .|:....:::.|....:...|:...::..::...:.....||.          |.
Human   386 ----------FSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTR----------TT 430

  Fly   461 VGSDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGE 525
            ...|....|.::|     ..:|  |.|  ....|.:.:.|..|       |:.....|:...||.
Human   431 QWEDPRTQGMIQE-----PALP--PGW--EMKYTSEGVRYFVD-------HNTRTTTFKDPRPGF 479

  Fly   526 RAALEVCRGYPLPFDPND----------------PNTEVVTTMAVDGRESDKQRRLNMDGNYNFL 574
            .:..:  :|.|..:|.:.                |:...::.......|...|:.:||
Human   480 ESGTK--QGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNM------- 535

  Fly   575 DLSGEGAKKTSGSGSGFILMKKP-----EIYTFSIMKGSMGFGFTIADSACGQIVK--------K 626
                                 ||     .:|.  ||:|..|..:       |.|.:        :
Human   536 ---------------------KPYDLRRRLYI--IMRGEEGLDY-------GGIAREWFFLLSHE 570

  Fly   627 ILDRNCCTQLME----GDVLLEINGLNVRNKPHF-----------------------YVVELLKE 664
            :|:...|  |.|    .:..|:||..:..|..|.                       :.:...|.
Human   571 VLNPMYC--LFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKR 633

  Fly   665 CSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLP 729
            .....||...::..  ||...|::..:.:        .|....||        :||..|..|:|.
Human   634 MLNKRPTLKDLESI--DPEFYNSIVWIKE--------NNLEECGL--------ELYFIQDMEILG 680

  Fly   730 MRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKP---LQLQTQGKSNSSLQE-----LDDI 786
                             :...:|:.:.|:.....|...   :.|.|..:....::|     ||..
Human   681 -----------------KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGF 728

  Fly   787 PYMDPYPKISRLSERLAEVTLQG 809
            ..:.|...:....|:..|:.|.|
Human   729 NEVAPLEWLRYFDEKELELMLCG 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/28 (43%)
		WW	342..372	CDD:238122	12/29 (41%)
		PDZ	443..534	CDD:214570	16/90 (18%)
		DegQ	<455..534	CDD:223343	14/78 (18%)
		PDZ_signaling	606..668	CDD:238492	14/96 (15%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		35/165 (21%)
		Atrophin-1	<164..343	CDD:331285	51/213 (24%)
		WW	302..331	CDD:306827	13/45 (29%)
		WW	332..361	CDD:306827	12/28 (43%)
		WW	407..435	CDD:306827	3/37 (8%)
		WW	447..477	CDD:238122	8/40 (20%)
		HECTc	516..868	CDD:238033	49/310 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810